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Phase 2a study to evaluate the safety, pharmacokinetics, and clinical activity of the PI3K / mTOR inhibitor GDC-0084 given to glioblastoma (GBM) patients with unmethylated MGMT promotor status

Al's Comment:

 

 This is an experimental drug - which in this poster from ASCO shows a small trial of 8 patients with newly diagnosed glioblastoma, unmethylated MGMT, who did pretty good compared to what we have seen previously with Temozolomide.  This opens a new option for unmethylated MGMT patients, and perhaps eventually in combinations for all gbm (and DIPG and brain met patients.

 


Posted on: 06/01/2020

Phase 2a study to evaluate the safety, pharmacokinetics, and clinical activity of the PI3K / mTOR inhibitor GDC-0084 given to glioblastoma (GBM) patients with unmethylated MGMT promotor status 

 


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