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Tamoxifen Is a Candidate First-In-Class Inhibitor of Acid Ceramidase That Reduces Amitotic Division in Polyploid Giant Cancer cells-Unrecognized Players in Tumorigenesis

Al's Comment:

 Tamoxifen is an old drug approved for breast cancer. Many years ago, it was tried for glioblastoma. See https://virtualtrials.com/Tam1.cfm That was in the time before Temozolomide was available. Results were promising, but the results for Temozolomide were better so Tamoxifen lost favor.

This article shows a different way it may work, and it may have a role in the ultimate treatment cocktail.  By itself, it is obviously not good enough but if this article is correct, it might help other treatments work.

One idea I had is that a possible escape mechanism for Optune is tumor cells getting larger. Tamoxifen might stop the giant cells from forming.

This is a perfect use of our virtual trial system - to track how these additional drugs can help the standard treatments.  We need more people to participate.  Virtualtrials.com/brain

I had a relative who was diagnosed with a GBM in 1992 and she did well with Tamoxifen for about 5 years, which was amazing back then.

 


Posted on: 03/14/2020

Tamoxifen Is a Candidate First-In-Class Inhibitor of Acid Ceramidase That Reduces Amitotic Division in Polyploid Giant Cancer cells-Unrecognized Players in Tumorigenesis

 


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