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Identification of a novel role of IL-13Ra2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway

Al's Comment:

This article shows that most GBMs overexpress IL-13Rα2  and that this may be involved in making the tumor invasive, proliferation and angiogenesis.  There are a few experimental treatments that target this marker.  ICT-107 was a vaccine that showed remarkable results in a few subgroups of patients but "failed" their pivotal trial  and is no longer in development.  GB-13 is in preclinical testing and hopefully will get into clinical trials soon..


Posted on: 12/24/2018

Identification of a novel role of IL-13Rα2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway

 


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