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Long-term benefit of intra-arterial bevacizumab for recurrent glioblastoma.

Al's Comment:

 This is a different way to give Avastin - directly into an artery.  One case doesn't prove anything but it is very nice to see.


Posted on: 05/14/2017

J Exp Ther Oncol. 2017 May;12(1):67-71.

Long-term benefit of intra-arterial bevacizumab for recurrent glioblastoma.

Author information:

1
Brain Tumor Center, Department of Neurosurgery, Lenox Hill Hospital, New York, NY, USA.
2
Department of Neurosurgery, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
3
Department of Neurosurgery, State University of New York at Buffalo, NY, USA.
4
Department of Radiology, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
5
Department of Pathology, Weill Cornell Medicine, New York, NY, USA.
6
Department of Radiology, Weill Cornell Medicine, New York, NY, USA.

 

Abstract

OBJECTIVE:

Standard treatment for recurrent GBM is not yet established. We present a case demonstrating the benefit of intra-arterial (IA) bevacizumab with blood brain barrier disruption (BBBD) for the treatment of recurrent GBM. A 31 year-old man diagnosed with GBM, following primary resection, received temozolomide. After a second resection, he received one dose of IA bevacizumab with BBBD using mannitol, preventing regrowth for 2.5 years. Following tumor regrowth, the patient received another dose of IA bevacizumab with BBBD, which has prevented regrowth for another year.

 


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