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Effect of Bevacizumab Plus Temozolomide-Radiotherapy for Newly Diagnosed Glioblastoma with Different MGMT Methylation Status: A Meta-Analysis of Clinical Trials.

Al's Comment:

The MGMT status did not have much effect on the use of Avastin with newly diagnosed gbm patients.    It is good to see research on this topic, because people with unmethylated MGMT are usually relatively resistant  to Temodar.


Posted on: 10/01/2016

Med Sci Monit. 2016 Sep 29;22:3486-3492.
Effect of Bevacizumab Plus Temozolomide-Radiotherapy for Newly Diagnosed Glioblastoma with Different MGMT Methylation Status: A Meta-Analysis of Clinical Trials.
Du C1, Ren J2, Zhang R1, Xin T1, Li Z3, Zhang Z3, Xu X4, Pang Q1.
 
Author information:
1Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
2Department of Blood Transfusion, Liaocheng People's Hospital, Liaocheng, Shandong, China (mainland).
3Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, Shandong, China (mainland).
4Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, Shandong, China (mainland).
 
Abstract
 
BACKGROUND MGMT methylation status can influence the therapeutic effect and prognosis of glioblastoma (GBM). There are conflicting results from studies evaluating the efficacy of bevacizumab (BV) when it is combined with temozolomide (TMZ) and radiotherapy (RT) in patients diagnosed with GBM with different MGMT methylation status. MATERIAL AND METHODS Data were extracted from publications in PubMed, Embase, and The Cochrane Library, with the last search performed March 23, 2016. Data on overall survival (OS), progression-free survival (PFS), and MGMT methylation status were obtained. RESULTS Data from 3 clinical trials for a total of 1443 subjects were used for this meta-analysis. MGMT methylated and unmethylated patients showed improved PFS in the BV group (pooled HRs, 0.769, 95% CIs 0.604-0.978, P=0.032; 0.675, 95%CIs 0.466-0.979, P=0.038). For patients with either type of GBM, BV did not improve the OS based on the pooled HRs 1.132 (95% CIs 0.876-1.462; P=0.345) for methylated and 1.018 (95% CIs 0.879-1.179; P=0.345) for unmethylated. CONCLUSIONS Bevacizumab combined with temozolomide-radiotherapy correlated with improved PFS for treatment of patients with different MGMT methylation status of newly diagnosed GBM. There was insufficient evidence to determine the synergistic effects of combining BV with TMZ and RT on improving survival in patients with different MGMT methylation status.
PMID: 27684457 [PubMed - as supplied by publisher]

 


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