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Biological effect of an alternating electric field on cell proliferation and synergistic antimitotic effect in combination with ionizing radiation.

Al's Comment:

 This brings up an exciting possibility. Optune is not used during radiation now, for theoretical reasons - the radiation can irritate the skin and cause delayed healing, which may make the irritation from the electrodes worse. As far as I know it was never tried. Might be worth trying.


Posted on: 09/01/2016

Oncotarget. 2016 Aug 19. doi: 10.18632/oncotarget.11407. [Epub ahead of print]
Biological effect of an alternating electric field on cell proliferation and synergistic antimitotic effect in combination with ionizing radiation.
Kim EH1, Kim YJ1, Song HS2, Jeong YK1, Lee JY1, Sung J2, Yoo SH1, Yoon M2.
 
Author information:
1Korea Institute of Radiological & Medical Sciences, Seoul, 01812, Korea.
2Department of Bio-Convergence Engineering, Korea University, Seoul, 02841, Korea.
 
Abstract
 
Alternating electric fields at an intermediate frequency (100~300 kHz), referred to as tumour-treating fields (TTF), are believed to interrupt the process of mitosis via apoptosis and to act as an inhibitor of cell proliferation. Although the existence of an antimitotic effect of TTF is widely known, the proposed apoptotic mechanism of TTF on cell function and the efficacy of TTF are controversial issues among medical experts. To resolve these controversial issues, a better understanding of the underlying molecular mechanisms of TTF on cell function and the differences between the effects of TTF alone and in combination with other treatment techniques is essential. Here, we report experimental evidence of TTF-induced apoptosis and the synergistic antimitotic effect of TTF in combination with ionizing radiation (IR). For these experiments, two human Glioblastoma multiforme (GBM) cells (U373 and U87) were treated either with TTF alone or with TTF followed by ionizing radiation (IR). Cell apoptosis, DNA damage, and mitotic abnormalities were quantified after the application of TTF, and their percentages were markedly increased when TTF was combined with IR. Our experimental results also suggested that TTF combined with IR synergistically suppressed both cell migration and invasion, based on the inhibition of MMP-9 and vimentin.

 


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