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5-ALA Fluorescence Image Guided Resection of Glioblastoma Multiforme: A Meta-Analysis of the Literature

Al's Comment:

5-ALA is a dye that is used during surgery to allow the surgeon to better see where the tumor is. It is approved and used routinely in Europe for many years but not approved in the USA.  This article looks at all of the literature and shows that using the dye resulted in a much higher % of patients getting a total resection, and reported over 6 months increase in survival by using this dye.  That is one of the largest increases in survival of any treatment for GBMs, and it is a safe, oral dye with no known side effects (other than sensitivity to the sun for a few days). It is criminal that it is not in use here in the USA.

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