News Story: Full Text
Sponsored By
NovoCure Trial
Please Click On The Above Banner For More Details
Braintumor Website

 

Interim Data Show Increased Median Overall Survival of Brain Cancer Patients Treated with Tocagen’s Toca 511 & Toca FC, Compared to Published Benchmarks

Al's Comment:

Impressive results.. Especially the 6 month survival rate (for recurrent glioblastoma)  of 93.8% compared to historical rate of 59%.  It also did well with toxicity.  This is a gene therapy. First the virus has to be injected - either intra-tumorally, at the time of surgery or IV (right now they are doing the IV study combined with intra-tumoral). Then they wait and give the virus time to infect the tumor cells where it inserts a gene that produces an enzyme that converts a safe, low toxicity antifungal drug into a toxic chemotherapy.  . It only infects tumor cells and not normal cells. Visit their website to see how they made that possible!   Then they give the oral anti-fungal drug which is relatively non-toxic. This drug crosses the blood brain barrier and is harmless to normal human cells, but when it gets to a cell that was infected and has the enzyme, this drug, 5fc gets converted to the chemotherapy drug 5fu, and it kills those cells.   In theory it is the perfect magic bullet -  killing all tumor cells with minimal side effects.  In practice it doesn't kill all of the tumor cells, but those cells that aren't killed act as a reservoir for the virus and they wait another month and then repeat the 5FU. After a few cycles, most or all of the tumor cells should be gone. It worked well in animal models.  Too early to tell how it will work in people but this interim data looks pretty good.


IF the story does not appear below, Click HERE to view the text of the story!
Note: The original website is displayed below - we have no control over it and are not responsible for the content of it, we just report it! IF you click on anything below, it will take you off of our website!
Original Source: http://www.tocagen.com/press/toca-511-survival-data-surpasses-benchmarks/


(Everything below this line is from VirtualTrials.com!)

Click HERE to return to brain tumor news headlines


Home | Brain Tumor Guide | FAQs | Find A Treatment
Noteworthy Treatments | News | Virtual Trial | Videos | Novocure Optune® | Newsletter
Donations | Brain Tumor Centers | Survivor Stories | Temodar®
Fundraising For Research | Unsubscribe | Contact Us

Copyright (c) 1993 - 2018 by:
The Musella Foundation For Brain Tumor Research & Information, Inc
1100 Peninsula Blvd
Hewlett, NY 11557
888-295-4740