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Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma

Al's Comment:

 This is an interesting trial design - hey tested every combination of temodar and 3 add on drugs... there probably wasn't enough patients to be sure but early result look like adding isotretinoin  (Accutane) actually did worse than temodar alone, and none of the combinations did much better than temodar alone. The best was all 3 drugs plus temodar, but not by much over temodar alone.

 


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Original Source: http://neuro-oncology.oxfordjournals.org/content/early/2014/09/19/neuonc.nou155.abstract


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