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Brain Tumor Center to Study Vaccine North Shore center to study glioblastoma patients.

Al's Comment:

Dr Schulder is on our medical advisory board and one of my favorite brain tumor neurosurgeons..   he is doing a trial of rindopepimut (which used to be known as cdx-110). This is a vaccine against the Epidermal Growth Factor Receptor version 3(EGFRvIII) , which is a mutation of the EGFR which is found on normal cells. (The article is wrong on that point).  If EGFRvIII is found on your tumor, it is a bad sign - the tumor is of the more aggressive variety because this receptor makes the tumor grow faster. This vaccine inactivates the EGFRvIII.  The hope is that it can stop the tumor from growing, or even if it fails, it might be able to convert the tumor into a slower growing tumor with a better prognosis.

Best part is that it is relatively easy injections into the skin - not into the brain.

(Disclosure:  the company that makes rindopepimut  is a sponsor of our foundation, and Dr Schulder is on our medical advisory board)

Posted on: 08/02/2013

Brain Tumor Center to Study Vaccine

North Shore center to study glioblastoma patients.


Doctors at North Shore-LIJ are studying whether a vaccine is effective against a form of brain cancer.

The Brain Tumor Center at North Shore-LIJ’s Cushing Neuroscience Institute is enrolling newly diagnosed glioblastoma patients in the study.

 “The purpose of this research study is to determine whether adding the investigational brain cancer vaccine rindopepimut to the standard chemotherapy drug temozolomide helps patients with newly diagnosed glioblastoma live longer,” said Michael Schulder, MD, principal investigator of the study at North Shore-LIJ and vice chair of neurosurgery at North Shore University Hospital and Long Island Jewish Medical Center (LIJMC).  “Previous studies of patients who received rindopepimut and the standard chemotherapy drug had encouraging results compared to control patients who were treated with the chemotherapy drug alone.”

The study is being conducted at North Shore-LIJ’s Brain Tumor Center. 

 Participants must be at least 18 years of age, been newly diagnosed with glioblastoma and had or are scheduled to have surgery to remove the tumor, and had or are scheduled to have post-surgery radiation and chemotherapy with temozolomide, without growth of tumor during this time.  

Participants must be a candidate for and agree to receive adjuvant temozolomide therapy and not have received other investigational treatments for glioblastoma.  In addition, participants must have a tumor that test positive for the Epidermal Growth Factor Receptor (EGFR), a growth factor receptor found in normal and malignant tumor cells.

 All participants enrolled in the study will be closely monitored to determine if their cancer is responding to treatment and for any side effects that may occur.  Study participants will be followed for survival until study completion, estimated to be up to five years or longer.

For more information, call North Shore-LIJ’s Brain Tumor Center at (516) 562-3058 or go to


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