MGMT Promoter Methylation Status Can Predict the Incidence and Outcome of Pseudoprogression After Concomitant Radiochemotherapy in Newly Diagnosed Glioblastoma Patients
This talks about the relationship between pseudoprogression and MGMT status. We already knew that MGMT methylation status is very important in determining the prognosis.. and we already knew (from our last news blast) that people with pseudoprogression do better than people without. This ties it together and may be why: those positive MGMT patients - who would be expected to live longer), also are more likely to get pseudoprogresion.. This may mean the temodar works better as a radiation sensitizer when MGMT is methylated.
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Original Source: http://jco.ascopubs.org/content/26/13/2192.full
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