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Bevacizumab (Avastin) treatment of symptomatic pseudoprogression after boron neutron capture therapy for recurrent malignant gliomas. Report of 2 cases.

Al's Comment:

 Avastin has been used for treating radiation necrosis but this is the first time I heard of it being used to treat symptomatic pseudoprogression.  I guess it makes sense.  This article talks about using BNCT, which was tried decades ago and failed - but the technology has advanced to the point where it is promising again.  Combining BNCT with Avastin might make a big impact. It might allow higer doses of radiation with less harm. Very interesting.

Posted on: 03/08/2013

Neuro Oncol. 2013 Mar 3. [Epub ahead of print]
Bevacizumab treatment of symptomatic pseudoprogression after boron neutron capture therapy for recurrent malignant gliomas. Report of 2 cases.
Miyatake SI, Furuse M, Kawabata S, Maruyama T, Kumabe T, Kuroiwa T, Ono K.
Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan (S.-I.M., M.F., S.K., T.K.); Department of Neurosurgery, Tokyo Women's Medical College, Shinjuku, Tokyo, Japan (T.M.); Department of Neurosurgery, Tohoku University, Miyagi, Japan (T.K.); Radiation Oncology and Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Kumatori, Osaka, Japan (K.O.).
Background Bevacizumab, an anti-vascular endothelial growth factor antibody, has been used for the treatment of radiation necrosis. Thus far, however, there has been no definitive report on its use for the treatment of symptomatic pseudoprogression. Here we report 2 cases of successful treatment with bevacizumab for symptomatic pseudoprogression after boron neutron capture therapy (BNCT) was applied for recurrent malignant gliomas.MethodsTwo recurrent malignant gliomas received BNCT. Both cases were treated with intravenous administration of bevacizumab at the deterioration that seemed to be symptomatic pseudoprogression.ResultsThe first case was recurrent glioblastoma multiforme and the second was recurrent anaplastic oligoastrocytoma. Both cases recurred after standard chemoradiotherapy and were referred to our institute for BNCT, which is tumor-selective particle radiation. Just prior to neutron irradiation, PET with an amino acid tracer was applied in each case to confirm tumor recurrence. Both cases showed deterioration in symptoms, as well as on MRI, at intervals of 4 months and 2 months, respectively, after BNCT. For the first case, a second PET was applied in order to confirm no increase in tracer uptake. We diagnosed both cases as symptomatic pseudoprogression and started the intravenous administration of 5 mg/kg bevacizumab biweekly with 6 cycles. Both cases responded well to this, showing rapid and dramatic improvement in neuroimaging and clinical symptoms. No tumor progression was observed 8 months after BNCT.ConclusionsBevacizumab showed marked effects on symptomatic pseudoprogression after BNCT. BNCT combined with bevacizumab may prolong the survival of patients with recurrent malignant gliomas.
 PMID: 23460324 [PubMed - as supplied by publisher] 


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