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Durable complete remission of a brainstem glioma treated with a combination of bevacizumab and cetuximab.

Al's Comment:

 Obviously, the experiances of 1 patient does not prove anything, but this is an interesting combination.  There is a trial of cetuximab for Glioblastomas, using a super selective intra arterial delivery -which allows a much higher dose to the tumor.  Combining it with Avastim seems like a reasonable choice.


Posted on: 01/27/2013

Case Rep Oncol. 2012 Sep;5(3):676-81. doi: 10.1159/000341852. Epub 2012 Dec 20.

Durable complete remission of a brainstem glioma treated with a combination of bevacizumab and cetuximab.

Blesa JM, Mollá SB, Esparcia MF, Ortells JM, Godoy MP, Das AM, Magan BM, Pulla MP, Sanchez JL, Canales JB, Candel VA.

Department of Medical Oncology, Hospital de Dénia, Marina Salud, Dénia, Spain.

 

Abstract

Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevacizumab, in a third-line setting, that has offered a progression-free survival of 20 months. We consider here both potential mechanisms for the explanation of this result. First, the potential target of the cancer stem cells (CSCs) with these two antibodies, and second, the potential recruitment of the immune system to directly pursue the CSCs.

 

 PMID: 23341811 [PubMed - in process] 

 

 


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