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Use of nanoparticles for cerebral cancer.


Posted on: 06/23/2008

Tumori. 2008 Mar-Apr;94(2):271-7.


Use of nanoparticles for cerebral cancer.

Kreuter J, Gelperina S.

Institute for Pharmaceutical Technology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany. Kreuter@em.uni-frankfurt.de

Nanoparticles made of poly(butyl cyanoacrylate) (PBCA) or poly(lactic-co-glycolic acid) (PLGA) coated with polysorbate 80 or poloxamer 188 enable the transport of cytostatics such as doxorubicin across the blood-brain barrier (BBB). Following intravenous injection to rats bearing intracranially the very aggressive glioblastoma 101/8 these particles loaded with doxorubicin significantly increased the survival times and led to a complete tumor remission in 20-40% of the animals. Moreover, these particles considerably reduced the dose-limiting cardiotoxicity and also the testicular toxicity of this drug. The drug transport across the BBB by nanoparticles appears to be due to a receptor-mediated interaction with the brain capillary endothelial cells, which is facilitated by certain plasma apolipoproteins adsorbed by nanoparticles in the blood.

PMID: 18564616 [PubMed - in process]

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