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Coincidence vs cause: cure in three glioblastoma patients treated with brachytherapy.


Posted on: 09/09/2007

Can J Neurol Sci. 2007 Aug;34(3):339-42. Related Articles


Coincidence vs cause: cure in three glioblastoma patients treated with brachytherapy.

Dehdashti AR, Sharma S, Laperriere N, Bernstein M.

Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

BACKGROUND: Very long term survival after diagnosis of malignant glioma has been described in individual case reports. Survival of more than 10 years is extremely rare, especially when identified in 3 out of 71 patients assigned to one arm of a randomized controlled trial. PATIENTS: Three patients survived 11, 16, and 18 years following the diagnosis of glioblastoma and treatment with surgery, conventional fractionated radiation, and high-activity iodine-125 boost brachytherapy as part of a randomized controlled trial. CONCLUSION: Despite this apparent cause and effect relationship, statistical analysis shows no relationship between these cures and treatment with brachytherapy. Cure of glioblastoma remains rare.

PMID: 17803034 [PubMed - in process]

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