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Daily topotecan blocks glioblastoma growth in animal models.

Posted on: 12/20/2004

Daily topotecan blocks glioblastoma growth in animal models.

Angiogenesis Weekly, Dec 24, 2004 p10

2004 DEC 24 - ( &

"We have previously shown that topotecan, a topoisomerase I poison, inhibits hypoxia-inducible factor (HIF)-1alpha protein accumulation by a DNA damage-independent mechanism. Here, we report that daily administration of topotecan inhibits HIF-1alpha protein expression in U251-HRE glioblastoma xenografts," reported investigators in the United States.

"Concomitant with HIF-1alpha inhibition, topotecan caused a significant tumor growth inhibition associated with a marked decrease of angiogenesis and expression of HIF-1 target genes in tumor tissue," said A. Rapisarda and colleagues, U.S. National Cancer Institute, DTP Tumor Hypoxia Laboratory.

"These results provide a compelling rationale for testing topotecan in clinical trials to target HIF-1 in cancer patients," they suggested.

Rapisarda and colleagues published their study in Cancer Research (Schedule-dependent inhibition of hypoxia-inducible factor-1 alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts. Cancer Res, 2004;64(19):6845- 6848).

For additional information, contact G. Melillo, NCI, DTP Tumor Hypoxia Laboratory, Bldg 432, Room 218, Frederick, MD 21702, USA.

The publisher of the journal Cancer Research can be contacted at: American Association for Cancer Research, 615 Chestnut St., 17TH Floor, Philadelphia, PA 19106-4404, USA.

The information in this article comes under the major subject areas of Hypoxia, Oncology, Cancer, and Cancer Therapy.

This article was prepared by Angiogenesis Weekly editors from staff and other reports. Copyright 2004, Angiogenesis Weekly via &

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