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Response of neoplastic meningitis from solid tumors to oral capecitabine.


Posted on: 02/10/2004

Response of neoplastic meningitis from solid tumors to oral capecitabine.

J Neurooncol. 2003 Nov;65(2):167-72. Related Articles, Links
Giglio P, Tremont-Lukats IW, Groves MD.

Neuro-Oncology Department, University of Texas--M.D. Anderson Cancer Center, TX 77030, USA.

Neoplastic meningitis (NM) is a major challenge for the neuro-oncologist as it constitutes a relatively common clinical problem in systemic and central nervous system cancers, and is very difficult to treat. NM portends a significant worsening in prognosis. Chemotherapeutic treatment options are limited, and not particularly effective. We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil. We believe capecitabine warrants further investigation in patients with NM. In some patients, its use may result in clinical and radiographic tumor responses, improved quality of life, and possibly increased survival.
Publication Types: Case Reports
PMID: 14686737 [PubMed - indexed for MEDLINE]


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