Tamoxifen Is a Candidate First-In-Class Inhibitor of Acid Ceramidase That Reduces Amitotic Division in Polyploid Giant Cancer cells-Unrecognized Players in Tumorigenesis
Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)
Tamoxifen is an old drug approved for breast cancer. Many years ago, it was tried for glioblastoma. See https://virtualtrials.com/Tam1.cfm That was in the time before Temozolomide was available. Results were promising, but the results for Temozolomide were better so Tamoxifen lost favor.
This article shows a different way it may work, and it may have a role in the ultimate treatment cocktail. By itself, it is obviously not good enough but if this article is correct, it might help other treatments work.
One idea I had is that a possible escape mechanism for Optune is tumor cells getting larger. Tamoxifen might stop the giant cells from forming.
This is a perfect use of our virtual trial system - to track how these additional drugs can help the standard treatments. We need more people to participate. Virtualtrials.com/brain
I had a relative who was diagnosed with a GBM in 1992 and she did well with Tamoxifen for about 5 years, which was amazing back then.
Posted on: 03/14/2020
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