Very good results, but these are small studies. In the newly diagnosed group, 7 of 15 patients had a complete response. This is with unmethylated MGMT patients which is a much worse group than methylated.  The data on the recurrent GBM is not available but they describe the trial!

It is possible that Val-083 should be used instead of Temodar for MGMT unmethylated patients.  Val-083 is  similar to Temodar - it is a chemotherapy (but IV not oral), but works at a different part of the DNA strand so the MGMT repair enzyme can not undo the damage like it does with Temodar.  (A GMB patient with unmethylated MGMT produces a lot of the repair enzyme, making Temodar almost ineffective).