Ziopharm Oncology Completes Enrollment of Controlled IL-12 Monotherapy Expansion Substudy in Phase 1 Brain Cancer Trial
Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)
This is a fascinating gene therapy. Follow the link in the article to the video explaining how it works. They have the ability to insert a gene into the cancer cells which can be controlled by an oral drug - which turns on the production of IL-12 in the infected cells. Stopping the oral drug turns off the production of IL-12 and they can fine tune the amount of IL-12 produced by adjusting the oral dose of the drug. IL-12 turns on the immune system and helps your body fight the cancer. The next step is to add a checkpoint inhibitor, which have not worked that great with brain tumors but this gene therapy might be able to make the checkpoint inhibitors work for brain tumors!
Posted on: 02/11/2019
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