Alternating Electric Fields (TTFields) Activate Cav1.2 Channels in Human Glioblastoma Cells.
Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)
This is a very technical article that says that adding a calcium channel blocker to TTFields (Optune) may work better than TTFields alone. There are many calcium channel blocking drugs available, approved as medications to treat high blood pressure. The authors used Benidine, which is approved in Asia but not the USA. They suggest, but did not try, Nifedipine may also work. This is available in the USA for high blood pressure and is easily available.
This is perfect for our Virtual Trial project. (See virtualtrials.com click on Virtual trial for details and to join). We can observe patients who are using Optune and compare those who also report using Nifedipine compared to those who do not report using Nifedipine. We do not have any patients reporting that combination yet - so we need more participants! All brain tumor patients should participate so when things like this come up we can just press a few keys on the keyboard and have the answer!
Posted on: 01/26/2019
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