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Transporter Inhibition Reduces Glioma-Related Brain Edema

Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)


Posted on: 05/12/2008

Transporter Inhibition Reduces Glioma-Related Brain Edema


NEW YORK MAY 12, 2008 (Reuters Health) - Inhibition of a glutamate transporter called xCT may help reduce the brain edema seen with malignant gliomas and possibly improve survival, according to animal study findings.

Brain edema and neuron death are key features of malignant brain tumors, Dr. Ilker Y. Eyupoglu, from the University of Erlangen-Nuremberg in Germany, and colleagues note. The mechanisms underlying these processes are not fully understood, but are thought to involve excessive accumulation of glutamate.

With this possible mechanism in mind, the researchers used small interfering RNA to silence tumor cell xCT in a murine model of glioma. In addition to reducing edema, this treatment blocked neurodegeneration and improved survival, according to the report in the May 11th online issue of Nature Medicine.

"Diminished glutamate secretion clearly lessens neurodegeneration and alleviates perifocal edema, thus indicating that xCT may mediate these clinically relevant malignancy characteristics of primary brain tumors," the authors conclude.



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