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Novel drug delivery system using thermoreversible gelation polymer for malignant glioma.


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Website: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16292493&dopt=Abstract

Posted on: 12/02/2005

Novel drug delivery system using thermoreversible gelation polymer for malignant glioma.

J Neurooncol. 2005 Nov 15;:1-7 [Epub ahead of print] Related Articles, Links Arai T, Joki T, Akiyama M, Agawa M, Mori Y, Yoshioka H, Abe T.

Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan, takao-a@jikei.ac.jp.

Many approaches to local tumor treatment have been reported and their efficacy demonstrated in patients with malignant glioma. We studied thermoreversible gelation polymer (TGP) as a novel drug delivery system (DDS) for treating this type of tumor. TGP exhibits sol-gel transition i.e., is water-soluble in the sol phase below the chosen sol-gel transiting temperature and water-insoluble in the gel phase above this temperature. We conjugated doxorubicin with TGP to prepare doxorubicin-TGP (DXR-TGP), then studied the kinetics of doxorubicin release from TGP and the antitumor activity of DXR-TGP in vitro and in vivo. The diffusive speed of doxorubicin from TGP was 9.4x10(-7) cm(2)/s and doxorubicin was reliably released from TGP. DXR-TGP showed antitumor activity against the human glioma cell lines T98G and U87MG and in a subcutaneous tumor model in nude mice. Pathologically, detection of the proliferation marker Ki-67 was considerably lower in the DXR-TGP group than in the control group (30-40% vs. 60-70%, respectively). This is to the best of our knowledge the first report of TGP as a novel drug delivery system, and further we provide evidence that TGP exhibits potential for use as a novel DDS for malignant glioma.

PMID: 16292493 [PubMed - as supplied by publisher]



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