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Study: Compound suppresses cancer growth


Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)



Website: http://www.sciencedaily.com/upi/index.php?feed=Science&article=UPI-1-20050830-15580900-bc-us-cancercompound.xml

Posted on: 08/30/2005

Study: Compound suppresses cancer growth

WASHINGTON, Aug. 30 (UPI) -- Scientists say they've found a non-toxic chemical compound that suppresses tumor growth and size in mice without unwanted side effects.


The compound -- a carbohydrate known as OGT2378 -- blocks the production of an enzyme that cancer cells need to make gangliosides -- molecules found in the membranes of most cells. When secreted by cancer cells, gangliosides suppress the immune system and promote growth of new blood vessels necessary for tumor growth and survival.

"Cancer cells produce gangliosides at a much more rapid rate than normal cells," said Dr. Stephan Ladisch, director of the Center for Cancer and Immunology Research at the Children's Research Institute. "By interfering with this process we can stop a tumor from growing in a rather dramatic fashion without damaging the normal tissue surrounding it."

The study's findings were presented Tuesday in Washington during the 230th national meeting of the American Chemical Society, the world's largest scientific society.

Copyright 2005 by United Press International. All Rights Reserved



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