News Story: Full Text
Sponsored By
Gleolan for brain tumors
Please Click On The Above Banner For More Details
Braintumor Website

Erthropoietin improves learning and memory impairment after whole brain irradiation:

Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)


Posted on: 03/30/2004

Erthropoietin improves learning and memory impairment after whole brain irradiation:

Public release date: 30-Mar-2004
Contact: Aimee Frank
American Association for Cancer Research
Abstract No. 3125

A drug that is normally used to fight anemia in cancer patients may also help brain tumor patients retain thinking, memory and concentration after radiation treatment, said Shun Wong, M.D., a researcher with Sunnybrook and Women's College Health Science Centre, Toronto.

Wong said that in animal studies, a single dose of erythropoietin (EPO) one hour after whole brain irradiation dramatically improved learning and memory function in mice.

"In our study, the animals that received radiation treatment alone showed considerable cognitive impairment," Wong said. "They acted confused and performed poorly on tests of memory. "

"On the other hand, mice that were first treated with radiation and then systemically injected with EPO maintained cognitive function that was no different than control mice, and substantially better than the irradiated mice that did not receive EPO," Wong said.

Mice treated with EPO after whole brain radiation successfully negotiated radial maze and hole-board tests as well as non-irradiated mice, Wong said. While EPO-treated irradiated mice demonstrated no behavioral or learning impairment, animals treated with EPO alone showed no boost or improvement in cognitive function.

Radiation treatment of brain tumors often leaves patients with late neurocognitive impairment. Patients complain of difficulty in concentration, memory and thinking. The application of EPO treatment in conjunction with radiation therapy to reduce brain tumor mass holds promise for human brain cancer patients to protect innate cognitive function during and after radiation treatment.

"We conclude that systemic treatment of EPO protects animals from learning and memory impairment after whole brain radiation," Wong said. Further studies are underway to determine the cellular and molecular changes in the brain due to EPO neuro protective treatment.

Click HERE to return to brain tumor news headlines

Home | Brain Tumor Guide | FAQs | Find A Treatment
Noteworthy Treatments | News | Virtual Trial | Videos | Novocure Optune® | Newsletter
Donations | Brain Tumor Centers | Survivor Stories | Temodar®
Fundraising For Research | Unsubscribe | Contact Us

Copyright (c) 1993 - 2020 by:
The Musella Foundation For Brain Tumor Research & Information, Inc
1100 Peninsula Blvd
Hewlett, NY 11557