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Prognostic value of the MIB-1 labeling index for central neurocytomas

Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)


Posted on: 03/26/2004

Prognostic value of the MIB-1 labeling index for central neurocytomas

Dirk Rades, MD, Steven E. Schild, MD and Fabian Fehlauer, MD

From the Department of Radiation Oncology (Drs. Rades and Fehlauer), University Hospital Hamburg–Eppendorf, Hamburg, Germany; and Department of Radiation Oncology (Dr. Schild), Mayo Clinic Scottsdale, AZ.

Address correspondence and reprint requests to Dr. D. Rades, Department of Radiation Oncology, University Hospital Hamburg–Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; e-mail:

Although central neurocytomas are generally described as benign CNS lesions, malignant behavior including craniospinal dissemination and tumor-related death may occur. This meta-analysis was performed to investigate the prognostic value of the MIB-1 labeling index. Data were obtained not from the literature alone but also from contact with the authors. The data suggested an MIB-1 index score of >3% to be associated with a worse prognosis for local control (p < 0.0001) and survival (p = 0.0004).

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