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Pediatric Supratentorial High-Grade Gliomas

Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)


Posted on: 03/18/2003

Pediatric Supratentorial High-Grade Gliomas

from Neurosurgical Focus

Posted 03/13/2003

Mandeep S. Tamber, M.D., James T. Rutka, M.D., Ph.D., F.R.C.S.(C)


The purpose of this review is to highlight some of the pertinent concepts and controversies surrounding the diagnosis and treatment of pediatric supratentorial high-grade gliomas. Unlike the adult counterparts, pediatric high-grade gliomas are likely derived from distinct cytogenetic and molecular alterations. Surgery has been shown to play a role in extending patient survival. Some success is associated with the provision of chemotherapy. Radiotherapy remains an important adjunct in children older than age 3 years. The challenges involved in improving the poor prognosis of children in whom these very aggressive tumors have been diagnosed will be discussed, as well as some of the novel approaches being investigated to improve patient survival and quality of life. [Note: click on the link above for the full text of this article. You may have to complete the free registration process first]

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