News Story: Full Text
Sponsored By
Gamma Tiles
Please Click On The Above Banner For More Details
Braintumor Website


Nobel Prize Excerpts (AP) ...The findings in the cell cycle field are about to be applied to tumor diagnostics.......Increased levels of CDK-molecules and cyclins are sometimes found in human tumors, such as breast cancer and brain tumors.... - Oct 08 7:54 AM ET


Al Musella's Comments: (This is his personal views and are not necessarily the views of the Musella Foundation!)



Website: http://dailynews.yahoo.com/h/ap/20011008/hl/nobel_medicine_citation_1.html

Posted on: 10/08/2001

Yahoo! News News Home - Yahoo! - My Yahoo! - News Alerts - Help

Associated Press
Home  Top Stories  Business  Tech  Politics  World  Local  Entertainment  Sports  Op/Ed  Science   Health   Full Coverage
Health - Associated Press - updated 10:37 AM ET Oct 8
My Add to My Yahoo!
Reuters  |  AP  |  ABCNEWS.com  |  HealthSCOUT  |  Yahoo! Health  |  Videos  

Monday October 8 7:54 AM ET "Nobel Prize Excerpts"

Nobel Prize Excerpts

Photos
AP Photo
AP Photo

 

By The Associated Press,

Excerpts from the citation by the Nobel Assembly at the Karolinska Institute for the 2001 Nobel Prize in Physiology or Medicine.

-

This year's Nobel laureates ... have made seminal discoveries concerning the control of the cell cycle. They have identified key molecules that regulate the cell cycle in all eukaryotic organisms, including yeasts, plants, animals and humans. These fundamental discoveries have a great impact on all aspects of cell growth. Defects in cell cycle control may lead to the type of chromosome alterations seen in cancer cells. This may in the long term open new possibilities for cancer treatment.

-

It is of central importance in the fields of biology and medicine to understand how the cell cycle is controlled. This year's Nobel laureates have made seminal discoveries at the molecular level of how the cell is driven from one phase to the next in the cell cycle.

-

Leland Hartwell realized already at the end of the 1960s the possibility of studying the cell cycle with genetic methods. He used baker's yeast, Saccharymyces cerevisiae, as a model system, which proved to be highly suitable for cell cycle studies.

-

Paul Nurse followed Hartwell's approach in using genetic methods for cell cycle studies. He used a different type of yeast, Schizzosaccharomyces pombe, as a model organism. This yeast is only distantly related to baker's yeast, since they separated from each other during evolution more than one billion years ago.

-

Tim Hunt discovered the first cyclin molecule in the early 1980s. Cyclins are proteins formed and degraded during each cell cycle. The discovery of cyclin, which was made using sea urchins, Arbacia, as a model system, was the result of Hunt's finding that this protein was degraded periodically in the cell cycle.

-

Most biomedical research areas will benefit from these basic discoveries. The findings in the cell cycle field are about to be applied to tumor diagnostics. Increased levels of CDK-molecules and cyclins are sometimes found in human tumors, such as breast cancer and brain tumors. The discoveries may in the long term also open new principles for cancer therapy. Already now clinical trials are in progress using inhibitors of CDK-molecules.

Email this story - View most popular  |  Printer-friendly format



Click HERE to return to brain tumor news headlines


Home | Brain Tumor Guide | FAQs | Find A Treatment
Noteworthy Treatments | News | Virtual Trial | Videos | Novocure Optune® | Newsletter
Donations | Brain Tumor Centers | Survivor Stories | Temodar®
Fundraising For Research | Unsubscribe | Contact Us

Copyright (c) 1993 - 2020 by:
The Musella Foundation For Brain Tumor Research & Information, Inc
1100 Peninsula Blvd
Hewlett, NY 11557
888-295-4740