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Note: The comments under each article title are the opinion of our president, Al Musella, DPM, and do not reflect official policy of the Musella Foundation!

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06/11/18 Reviving the protector: new tactic against medulloblastoma        

 There is a huge unmet need in this area. Hope it works well it trials.

06/10/18 Laser interstitial thermal therapy for posterior fossa lesions: An initial experience.        

 This suggests that LITT is safe in the posterior fossa area. It appears relatively safe and may be another option for treatment of tumors in this difficult location

06/02/18 Returning to work after multimodal treatment in glioblastoma patients.        

Returning to work after multimodal treatment in glioblastoma patients.         This is one of the most important outcome of brain tumor treatments. It should be considered an important primary endpoint for clinical trials: what % of patients  are able to work full time at the level of their previous job at 1,2,3 year point? What % of patients can work at least part time at any job at 1,2,3 years.  This is important because for the first time, we are seeing long term survivors of GBMs who can actually work full time at high level jobs, many years down the line.  Even if a treatment only improves median survival by a small amount, but allows those who do survive to engage in meaningful work - that is a breakthrough. For example, many years ago there were reports of a high % of long term survivors with intense radiation.  However, it caused so much damage that most survivors were bedridden for the rest of their lives.  More recently, with DC-Vax, ICT-107, Toca 511 / Toca FC, and others, we see some long term survivors who are functioning at the highest level - executive jobs, having families, driving and enjoying life.   That is what we strive for. So it should be a formal endpoint!

05/31/18 Brain Tumor Awareness Month Webinar Series are now available free on demand!        

 Let us know what you think of this format, and if you have ideas for speakers or topics for future webinars!

05/31/18 FDA-approved drug for lymphoma and leukemia may help treat common type of brain tumor        

 This is too early to say if it helps or not, but is another treatment that is available if you have the right target.

05/30/18 Trump signs 'Right to Try Act' aimed at helping terminally ill patients seek drug treatments        

 This is a big step forward!  I am now working on how to use this to the advantage of brain tumor patients.  If anyone wants to try to get a drug through this pathway, please join our online support group at and discuss it there!

05/29/18 First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma        
This article is so important that I am placing my editorial comments into the full text part of this entry so more people see it, along with a link to the full article.

05/28/18 Minute Particles could Assist Battling Brain Cancer        

 Great concept. Probably wrong drug but they are working on it.  Maybe they should try 06bg


05/25/18 Superselective intraarterial cerebral infusion of cetuximab with blood brain barrier disruption combined with Stupp Protocol for newly diagnosed glioblastoma.        

 This is only 1 case report but it shows great results using an old drug in a new way.

05/25/18 Midatech Pharma Commences First In-Human Study Of Brain Cancer Drug        

 This is a new way to get drugs to the tumor!

05/24/18 Brain Tumor Awareness Month Webinar Series: Special Guest Dr Eric T. Wong, MD, Co-Director, Brain Tumor Center, Beth Israel Deaconess Medical Center (Sunday 5/27/18) 7pm Eastern Time!        

 This is the final speaker in our Brain Tumor Awareness Month Webinar Series!  Dr. Wong was in charge of the USA trials for Optune and will discuss all aspects of the use of Optune for brain tumors!

05/24/18 Heat shock protein peptide complex-96 vaccination for newly diagnosed glioblastoma: a phase I, single-arm trial.        

 Pretty good results, but it is in a small trial.   

05/24/18 Patterns of care and outcomes of chemoradiation versus radiation alone for MGMT promoter unmethylated glioblastoma.        

 This study says that for glioblastoma patients with unmethylated MGMT, adding Temodar to radiation does not improve survival or progression free survival.    This is a retrospective study that does not control for other factors, but it is interesting. It opens the door for experimenting with other treatments for newly diagnosed MGMT unmethylated patients, such as perhaps substituting Val-083 instead of Temodar.

05/23/18 MimiVax Announces Positive Interim Results from Phase II Trial of SurVaxM Immunotherapy for the Treatment of Newly Diagnosed Glioblastoma        

 Excellent results with a simple shot in the arm -and minimal side effects. This is the type of treatment that we need access to now - not years from now.

05/23/18 New Published Evidence for Deadly High-Grade Gliomas Linked to Improved Survival        

 This paper shows that the new hi-tech tools from NICO allow for the removal of deep tumors in a safer way than before. It is FDA cleared, so neurosurgeons can use it now.


05/22/18 House approves 'right to try,' sends bill to Trump's desk        

 This is the bill we asked you to help with by calling and writing your representatives!  

Thanks for your help!

05/20/18 URGENT ACTIVISM ALERT: Right To Try Bill up for vote this Tuesday!        

 We need lots of emails and calls!  

05/18/18 Brain Tumor Awareness Month Weminar Series: Special Guest Dr Henry Friedman        

 This is an opportunity to talk to Dr Henry Friedman and ask questions on any brain tumor related topics!

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