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09/10/17 How a Dallas reporter pushed the FDA for a new approach to treating brain cancer        

 This is about our proposal to speed up the search for the cure.  They mention there is a legal problem  we are working on that and it appears that will not be an issue at all - our proposal could be implemented under current laws.    If interested, we are discussing it in the braintumor treatments online support group at https://virtualtrials.com/braintumor-treatments.cfm

 




09/09/17 NCCN Announces First Patient Dosed in NCCN-Peregrine Pharmaceuticals Collaborative Study of Bavituximab        

 Interesting new approach. Will be watching this closely!




09/07/17 Curtana Pharmaceuticals Successfully Completes Pre-IND Submission for CT-179 for the Treatment of Malignant Gliomas        

 This sounds exciting - it is a new target which is not usually found on normal brain but is found in GBM cells - especially cancer stem cells




09/06/17 Zika Virus Kills Brain Tumor Cells, Researchers Find        
 I wasn't going to write about this but so many people asked about it already.  My thoughts are that it is way too early to tell if this will help patients. It is getting huge media coverage because of the association with Zika, when there are many other treatments that patients can get access to which have shown some good results in people.
 It is better to focus on the treatments that are available now or will be available soon.



09/06/17 Brain Cancer Survivor Strives to Increase Public Awareness Around Disease        

 People have no idea what our brain tumor patients and their loved ones are going through.




09/01/17 Synergistic inhibition of glioma cell proliferation by Withaferin A and tumor treating fields        

 This looks interesting and needs further study.




09/01/17 Lymphoma Patient’s Brain Tumor Disappeared After She Received JCAR017, Study Reports        

 This is only in 1 patient but worth keeping in mind if you have a CNS lymphoma that is not responding to standard treatments.  Hopefully they will eventually be able to use this technology for the more common brain tumors! 




08/27/17 STELLAR trial for Recurrent Anaplastic Astrocytoma        

 Orbus Therapeutics launched a new website for their clinical trial of oral Eflornithine (plus lomustine vs. lomustine alone).

 

Disclaimer: Orbus Therapeutics is a sponsor of the Musella Foundation.




08/27/17 OPTUNE OPEN HOUSE - NY Sept 9        

 This is for anyone thinking about using Optune.  It is a  lecture about the treatment, and there is a patient using the treatment that you can talk to.  It is for patients and caregivers.




08/18/17 Reengineering Immune System Cells to Fight Glioblastoma        

 This may lead to a breakthrough in the treatment of most cancers!






08/16/17 CHOP to lead new pediatric data resource center for research in childhood cancer, birth defects        

 This is the type of effort needed to make headway in the fight against cancer (and birth defects).   The Musella Foundation funded early work for this project which led to the big NIH grant which is making it a reality!




08/15/17 Curtana Pharmaceuticals Granted FDA Orphan Drug Designation for CT-179 for the Treatment of Gliomas        

 This targets Oligo2, which sounds like it might be a great target 




08/14/17 Successful use of equine anti-thymocyte globulin (ATGAM) for fulminant myocarditis secondary to nivolumab therapy.        

 This is a very rare, but very serious,  side effect of checkpoint inhibitors. Although it is only 1 patient, keep this in mind if you hear of this side effect.




08/14/17 Options to Treat a Glioblastoma        

 I was asked for my opinion on what I would do if I had a newly diagnosed gbm.. here is my response.  We can discuss it in the braintumor-treatments online group https://virtualtrials.com/braintumor-treatments.cfm

 




07/29/17 Early initiation of chemoradiation following index craniotomy is associated with decreased survival in high-grade glioma.        

 Very interesting study. It says that starting radiation therapy earlier than we usual do actually is worse for the patient. The study was performed just by looking at billing records.  I would like to see more research on this. Perhaps look at the reasons radiation was started earlier. Maybe those patients had a lot of residual tumor so they were rushed into radiation as there was less space for recurrence? Or had some other medical reasons.




07/24/17 Novocure™ Announces a Phase 1b Clinical Trial to Evaluate the Safety of Marizomib and Temozolomide in Combination with Optune® as Adjuvant Therapy in Patients with Glioblastoma        

 All new trials should consider adding an Optune arm. Currently, a few interesting trials are not allowing patients to use Optune at the same time as the trial.  I feel that is not ethical. Optune has been shown to more than double the 5 year survival rate for adult GBM.  If you have to make a choice between trying Optune with a proven benefit and minimal side effects to trying an experimental therapy with no track record and inknown side effects, I would choose Optune.  [Disclaimer: Novocure is a sponsor of the Musella Foundation]




07/23/17 Glioblastoma: New tools against brain cancer        

This is one of my favorite new treatments. It is too early to tell how well it works, but it looks promising.  Disclaimer: I am on the patient advisory board at the Brain Tumor Center at Duke (but have no financial involvement in this treatment)








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