10/10/17 Medicenna Presents Clinical Data on Initial Experience from Ongoing Phase 2b Study of MDNA55
They did not say how the patients did, but they did report that they were able to deliver the drug to the correct place in a higher percentage of the time than in previous trials. That was the big problem with previous trials involving convection enhanced delivery. In the first such trial, the PRECISE trial, it was found that most or all of the patients did not get the drug to the correct place - which didn't give the drug a chance to work - so the trial failed. More recently the Tocagen trials have used CED and have vastly improved the ability to get the drug where it needs to go. Hopefully this is another step toward getting the drug to the correct place 100% of the time.
(Disclaimer: Medicenna is a sponsor of the Musella Foundation)
10/07/17 Many new cancer drugs don't save lives
What these people do not understand is that for the hard to treat cancers - like glioblastoma, the cure is most likely not going to be a single drug. It will be a combination of several treatments. However, we can not easily test the combinations until the drugs are approved. The huge failure is they are not tracking the results. I feel the only way to home in on the ultimate cocktail is to track all cancer patients - the treatments they do and the outcome. Without that data we are doomed to failure.
09/29/17 I’m dying of brain cancer. I prepared to end my life. Then I kept living.
This is a common topic of conversation. My views are that assisted suicide has a place - but most consider it way too early, just like this man. You get diagnosed, read about the horrors of the diagnosis on the internet and give up. But what is missed is that some people do beat this. There is progress every week. Just this week, we published 2 articles showing major gains: adding CCNU to Temodar upped the average survival to 46 months.. which means half of the people lived longer than that! And the long term results of the Optune trial showing that the 5 year survival rate, which was stuck at 5% for the last 100 years or so, is now 13%. (Still bad, but a lot better than 5%)
09/19/17 New math developments lead to more improved brain cancer treatment
I agree completely. Advanced math is going to be the key to finding the cure. I think the path to the cure is having all patients tracked in the virtual trial registry, and analyzing the data to find the best combinations. (Along with getting early access to experimental treatments)
09/14/17 Treatment nonexistent for some glioblastoma patients
This is why we are always telling our patients to seek care at a major brain tumor center. You need experienced people taking care of you. I cringe when people tell me they are being treated at a small community hospital. Many times when staff at a community hospital calls us to ask about our copayment assistance program and we explain the covered treatments, they say "what is Optune?". You do not want to be treated at a center that doesn't keep up.
09/11/17 "Treatment Options for Glioblastoma and other Gliomas" Ben Williams' Aug 2017 Update
Ben Williams is a 22+ year GBM survivor who wrote an excellent book on his thoughts on how to approach a serious diagnosis. The book talks about a lot of treatments - so it is out of date as soon as it is published. So he puts together an update every year to keep it fresh. Starting last year, our medical editor, Stephen Western, has taken over the updates - with Ben's approval of all changes. We host these updates on virtualtrials.com as a free service! It is one of the more important articles on brain tumor treatments. This years update is 138 pages!
We discuss this on the braintumor treatments online group: https://virtualtrials.com/braintumor-treatments.cfm