Note: The comments under each article title are the opinion of our president, Al Musella, DPM, and do not reflect official policy of the Musella Foundation!
01/27/20 National Brain Tumor Society Provides Funding for the Development Novel Therapy with Potential to Treat Adult and Pediatric Brain Cancers
From our friends at the NBTS. There was a fascinating presentation at SNO that showed GBM patients with low EGFR levels might do better than those with High EGFR levels with the experimental drug Onc-201. I am happy to see they are going to test that in a trial. I wish them luck. Hopefully they will find out if it is EGFR that makes the difference or it is just that the low EGFR status is linked to a high DRD2 level - which is the target of Onc201. If the EGFR makes a difference, this opens the door to combination treatments targeting EGFR along with Onc-201 to hopefully help all patients.
01/15/20 Scientists breach brain barriers to attack tumors
I love this kind of research - shows they are thinking through the problem and looking for new avenues of attack. This is way too early to say if it will help people, as they only tried it in mice. Will keep an eye on it as they move into humans!
01/09/20 Survival analysis of patients with glioblastoma treated by long-term administration of temozolomide.
This is the reason why we like to see prospective trials. In this retrospective study, they looked at people who used Temodar for 6 months or less versus people who received more than 6 months of Temodar. The progression free survival was a little better but the overall survival was more than double (47 vs 20 months) in the long term group vs. the short term group. That would be very impressive except they did not give one group 6 months of Temodar and the other group more than 6. They just looked back to see how long patients used it. It is possible that the patients who used it longer were the ones in good shape and who were responding to it and the ones who stopped at or before 6 months did so because they were having problems, in which case you would expect the group doing well to live longer than the group not doing well.
01/08/20 New book takes a humorous look at brain cancer
Very well written book describes what happens from the first symptoms of a brain tumor through the surgery, radiation, chemo and all of the problems that arise. Worth the read.