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Displaying Stories 1 to 20 of 6,041
10/09/16 Exclusive: Interview With DelMar Pharmaceutical CEO Jeffrey Bacha
This drug, Val-083, might just be the next big step forward. Late stage trials are about to start. It already had been approved in China for other diseases, and over 1,000 patients took it and have shown that toxicity is not a problem. It might especially be useful for gbm patients who have unmethylated MGMT.
The article may have missed a little on the statistics. I doubt if 200,000 GBMs are diagnosed a year. They say "less than 200,000" but it is more like 20,000.
10/09/16 High response rate in phase I/II paediatric brain cancer trial
Luckily, the drug they used, dabrafenib, is already approved for other types of cancer so it can be used off label immediately. Unfortunately, in melanoma, it was found that most patients become resistant to it quickly. There is work going on now using another drug, Trametinib, combined with the dabrafenib, which may prevent that resistance. The FDA approved this combination for melanoma. Maybe it would work in brain tumors also!
10/05/16 Tocagen Presents Updated Tumor Response Data for its Cancer-Selective Gene Therapy
Pretty good results. 20% of the patients in the trial responded, but those that responded remain alive at 21-42 months. This means that the median survival they reported, 14.3 months, will go up as time goes on - assuming these patients continue to do well for a while! In the past, I have seen numbers reported of about 8 to 9 months average survival for recurrent gbms.. (this press release doesn't break down the % with anaplastic astrocytoma), but that is with everyone dead at the end of the trial.
And they mention the Musella Foundation as funding part of the work. Your donations at work! :)
We are starting a new fundraiser to raise money specifically to speed up approval for this treatment. For details, go to https://virtualtrials.com/toca_fund.cfm
10/01/16 Injecting live virus in brain tumors may fight cancer, study suggests
This video is about the Tocagen trial. They said that so far, it has doubled overall survival compared to historical survival times.
We are launching a new fundraiser to help speed up this trial and collect more data on how it works and how to make it work better. See virtualtrials.com/toca_fund.cfm for details. And for the first time ever, we are offering t-shirts, hats and jackets with the Tocagen motto: "No One Should Die Of Cancer" for donations!
10/01/16 Pioneering Studies Apply New Immunologic Insights to Glioblastoma
This is a completely new way of trying to treat brain tumors by suppressing cells in the blood that travel to the brain tumor and inhibit the immune system.
We (The Musella Foundation) funded part of the project! This is YOUR donations hard at work! Thanks
09/21/16 The Clinical Implications of Inconsistently Methylated Results from Glioblastoma MGMT Testing by Replicate Methylation-Specific PCR.
Excellent article. Apparently, when the MGMT methylation status test results show inconsistent methylation, it really should be thought of as being unmethylated. For background: MGMT is a gene that codes for an enzyme that repairs damage to the DNA caused by Temodar. If your MGMT genes are methylated, that means they are inactive and can not produce the repair enzyme. This makes Temodar work much better. However, if your MGMT is unmethylated (or apparently now - even inconclusive), the repair enzyme is produced which reverses the damage caused by Temodar, making it not really work.
This really didn't matter much until recently when a new drug, Val-083, was created which works similar to Temodar but on a different part of the DNA so that this repair enzyme can not reverse the damage. This drug is about to start phase 3 clinical trials. Worth considering for those whose test show unmethylated MGMT.
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