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Displaying Stories 1 to 20 of 6,023
09/21/16 The Clinical Implications of Inconsistently Methylated Results from Glioblastoma MGMT Testing by Replicate Methylation-Specific PCR.
Excellent article. Apparently, when the MGMT methylation status test results show inconsistant methylation, it really should be thought of as being unmethylated. For background: MGMT is a gene that codes for an enzyme that repairs damage to the DNA caused by Temodar. If your MGMT genes are methylated, that means they are inactive and can not produce the repair enzyme. This makes Temodar work much better. However, if your MGMT is unmethylated (or apparently now - even inconclusive), the repair enzyme is produced which reverses the damage caused by Temodar, making it not really work.
This really didn't matter much until recently when a new drug, Val-083, was created which works similiar to Temodar but on a different part of the DNA so that this repair enzyme can not reverse the damage. This drug is about to start phase 3 clinical trials. Worth considering for those whose test show unmethylated MGMT.
09/08/16 Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1?/PKM2 axis in glioblastoma cells.
The concept of cytomegalovirus being associated with GBMs is controversial. Some researchers say 100% of GBM samples have it, others say none of them have it. I tend to agree with the ones that say it is very common in GBM samples. IF that is true, this study may show how CMV can promote the formation of tumors. And that opens the door for treatments. There is already an approved drug that fights CMV, and there is a brain tumor vaccine under development that targets the CMV. Preliminary results look good. This study also identifies other downstream targets which may be exploited.
08/24/16 Update published for "Treatment Options For Glioblastoma and other Glioma"
This is the most important article on our website and is updated once a year.. Ben Williams originally wrote the book: Surviving Terminal Cancer: Clinical Trials, Drug Cocktails, and Other Treatments Your Oncologist Won't Tell You About" in 2002. Since treatment change so rapidly, it needed an update every year, and Ben graciously allowed us to host the yearly updates to distribute for free. This year, for the first time, our medical editor, Stephen Western, helped Ben update it. New this year is an easy way to see changes from previous editions - they are now in red. They did a great job and this is a must read for anyone who is interested in Brain Tumors.
08/18/16 Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma.
I had a relative do great for over 5 years with high dose tamoxifen for her gbm. It was relatively popular before Temodar came into use. Studies showed that it helped a small % of patients, but when it helped, it helped a lot. And it had minimal side effects. This article might explain why it helps some patients and not others. More research needs to be done.
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