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- Question: My 16-year-old daughter was diagnosed with medulloblastoma on 8/26/08. Her tumor was 100% resected, she has completed radiation therapy, and 6 of 9 chemotherapy treatments. Six of those treatments include Cisplatin. She has completed 4 of those 6 and is due to receive her next on Mon 7/20/08. She has lost 50% of her hearing 3000-8000hz. All MRI's since the initial have shown no sign of recurrence and her spinal fluid was clear after surgery.
I feel certain that another Cisplatin dose will further reduce her ability to hear. The clinical trial she is on calls for a half dose of Cisplatin at this stage (up to 40% loss at 2000hz). Conversations with other medullo patients confirms further hearing loss, whether half or full dose.
I feel like I'm trading the certainty of further hearing loss for whatever increment in reduction in recurrence those remaining 2 Cisplatin doses offer. Are there any studies showing the efficacy of cumulative Cisplatin doses at this stage? Further, were you in my shoes, what decision would you make in this case?
I'm trying to determine how much value the remaining 2 Cisplatin doses offer before we make a final decision regarding the next dose. Thank you in advance.
Tough call. No one knows the answer for the individual patient. Relapse or
return of the tumor is usually fatal. The first time of treatment is the
best chance for cure.