Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02764151 : First in Patient Study for PF-06840003 in Malignant Gliomas
PhasePhase 1
AgesMin: 18 Years Max: N/A
Eligibility
Inclusion Criteria:

- Diagnosis of WHO Grade IV glioblastoma or WHO Grade III anaplastic gliomas

- For patients with Grade IV GBM, recurrent disease at the time of the first or second
recurrence or progression. For patients with Grade III anaplastic gliomas, recurrent
disease at the time of at least a first recurrence but no more than a fourth
recurrence or progression

- Karnofsky performance score greater than or equal to 70%

- Adequate bone marrow, kidney and liver function

Exclusion Criteria:

- History of CNS bleeding within 6 months of registration

- Previous anti-angiogenics or anti-vascular endothelial growth factor within 12 months
of registration

- Requires treatment with high dose systemic corticosteroids defined as >2 mg/day

- Radiation therapy within 12 weeks of registration
LinksPermanent Link to THIS page: http://virtualtrials.com/nct/display1trial.cfm?nct=NCT02764151      |      Link to official Clinicaltrials.gov listing
Locations
Los Angeles, California
Facility: Ronald Reagan UCLA Medical Center, Drug Information Center
Investigator:
Contact:
Email not avaialable

Los Angeles, California
Facility: Ronald Reagan UCLA Medical Center
Investigator:
Contact:
Email not avaialable

Los Angeles, California
Facility: UCLA Clinical & Translational Research Center
Investigator:
Contact:
Email not avaialable

Los Angeles, California
Facility: UCLA Oncology Center
Investigator:
Contact:
Email not avaialable

Los Angeles, California
Facility: UCLA School of Medicine
Investigator:
Contact:
Email not avaialable

Boston, Massachusetts
Facility: Massachusetts General Hospital
Investigator:
Contact:
Email not avaialable

Boston, Massachusetts
Facility: Dana-Farber Cancer Institute
Investigator:
Contact:
Email not avaialable

Albuquerque, New Mexico
Facility: University of New Mexico Comprehensive Cancer Center
Investigator:
Contact:
Email not avaialable

New York, New York
Facility: Columbia University Medical Center
Investigator:
Contact:
Email not avaialable

New York, New York
Facility: Columbia University Medical Center
Investigator:
Contact:
Email not avaialable

New York, New York
Facility: CUMC Research Pharmacy
Investigator:
Contact:
Email not avaialable

Tarrytown, New York
Facility: Columbia Doctors Tarrytown
Investigator:
Contact:
Email not avaialable

Durham, North Carolina
Facility: Duke Cancer Center
Investigator:
Contact:
Email not avaialable

Durham, North Carolina
Facility: Duke University Medical Center, Duke Cancer Center
Investigator:
Contact:
Email not avaialable

Durham, North Carolina
Facility: The Preston Robert Tisch Brain Tumor Center at Duke
Investigator:
Contact:
Email not avaialable




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