Clinical Trial Details
Braintumor Website

[Information provided by:, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02698254 : Pilot Trial of Dose-Volume Constraints for Reirradiation of Recurrent Brain Tumors
AgesMin: N/A Max: N/A
Inclusion Criteria:

1. Previous pathologic confirmation of a tumor treated with radiation to the brain
completed at least 6 months prior to the start of planned reirradiation, except for
patients with tumors that are routinely diagnosed without biopsy, including germinoma
and optic pathway glioma. Patients with a history of cranial irradiation for leukemia
are eligible.

2. Patient must have received one and only one previous course of radiation to the brain,
delivered at 1.5 - 2.5 Gy/fraction, one fraction per day.

3. Multidisciplinary evaluation of the patient must be performed with a consensus
recommendation for reirradiation.

4. Patient may not receive concurrent chemotherapy with reirradiation, other than
temozolomide or bevacizumab given at the discretion of the treating neuro-oncologist.

5. Patient must have imaging findings within the last 3 months consistent with recurrent
disease in the brain. Pathologic diagnosis of recurrence is not required.

6. Patient may undergo surgical resection prior to reirradiation.

7. Dose-volume histogram data and cross-sectional imaging from previous radiation must be
obtained. Electronic dosimetry records in DICOM format from previous radiation are
strongly preferred.

8. Signed informed consent by patient and/or parents or legal guardian.

9. Lansky/Karnofsky Performance Status score of 50-100.

Exclusion Criteria:

1. Patients with recurrent diffuse intrinsic pontine glioma (DIPG)

2. Pregnancy
LinksPermanent Link to THIS page:      |      Link to official listing
Houston, Texas
Facility: University of Texas MD Anderson Cancer Center
Contact: MD Anderson Health Information Specialist Phone: 877-632-6789
Email not avaialable

Home | Brain Tumor Guide | FAQs | Find A Treatment
Noteworthy Treatments | News | Virtual Trial | Videos | Novocure Optune® | Newsletter
Donations | Brain Tumor Centers | Survivor Stories | Temodar®
Fundraising For Research | Unsubscribe | Contact Us

Copyright (c) 1993 - 2018 by:
The Musella Foundation For Brain Tumor Research & Information, Inc
1100 Peninsula Blvd
Hewlett, NY 11557

Website Design By
World Wide Websites