Clinical Trial Details
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NCT02698254 : Pilot Trial of Dose-Volume Constraints for Reirradiation of Recurrent Brain Tumors
AgesMin: N/A Max: N/A
Inclusion Criteria:

1. Previous pathologic confirmation of a tumor treated with radiation to the brain
completed at least 6 months prior to the start of planned reirradiation, except for
patients with tumors that are routinely diagnosed without biopsy, including germinoma
and optic pathway glioma. Patients with a history of cranial irradiation for leukemia
are eligible.

2. Patient must have received one and only one previous course of radiation to the brain,
delivered at 1.5 - 2.5 Gy/fraction, one fraction per day.

3. Multidisciplinary evaluation of the patient must be performed with a consensus
recommendation for reirradiation.

4. Patient may not receive concurrent chemotherapy with reirradiation, other than
temozolomide or bevacizumab given at the discretion of the treating neuro-oncologist.

5. Patient must have imaging findings within the last 3 months consistent with recurrent
disease in the brain. Pathologic diagnosis of recurrence is not required.

6. Patient may undergo surgical resection prior to reirradiation.

7. Dose-volume histogram data and cross-sectional imaging from previous radiation must be
obtained. Electronic dosimetry records in DICOM format from previous radiation are
strongly preferred.

8. Signed informed consent by patient and/or parents or legal guardian.

9. Lansky/Karnofsky Performance Status score of 50-100.

Exclusion Criteria:

1. Patients with recurrent diffuse intrinsic pontine glioma (DIPG)

2. Pregnancy
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