Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02360215 : Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases
PhasePhase 3
AgesMin: 18 Years Max: N/A
Eligibility
Inclusion Criteria:

- PRIOR TO STEP 1 REGISTRATION:

- Brain metastases outside a 5-mm margin around either hippocampus must be visible on
contrast-enhanced magnetic resonance imaging (MRI) performed =< 21 days prior to Step
1 registration; an allowed exception, regarding ability to image brain metastases,
would be that patients who had undergone radiosurgery or surgical resection and are
planning adjuvant WBRT do not have to have visible disease but do need a pre-surgery
MRI or computed tomography (CT) scan demonstrating brain metastases; however, the
brain metastases could not have been within 5 mm of either hippocampus

- Patients must have a gadolinium contrast-enhanced three-dimensional spoiled gradient
(SPGR), magnetization-prepared rapid gradient echo (MP-RAGE), or turbo field echo
(TFE) axial MRI scan with standard axial and coronal gadolinium contrast-enhanced
T1-weighted sequence and axial T2/FLAIR sequence acquisitions; to yield acceptable
image quality, the gadolinium contrast-enhanced three-dimensional SPGR, MP-RAGE, or
TFE axial MRI scan should use the smallest possible axial slice thickness not
exceeding 1.5 mm; the associated coronal and sagittal contrast-enhanced T1 sequences
can be up to 2.5 mm in slice thickness; this MRI must be obtained =< 21 days prior to
step 1 registration; the vendor specific MRI protocols are available for download from
the Alzheimer's Disease Neuroimaging Initiative (ADNI)

- Patients must provide study-specific informed consent prior to registration

- PRIOR TO STEP 2 REGISTRATION:

- The following baseline neurocognitive assessments must be completed prior to Step 2
registration: HVLT-R, TMT, and COWA; the neurocognitive assessment will be uploaded
into the NRG RAVE System for evaluation by Dr. Wefel; once the upload is complete, a
notification will be sent to proceed to Step 2; NOTE: completed baseline
neurocognitive assessments can be uploaded at the time of Step 1 registration

- Pathologically (histologically or cytologically) proven diagnosis of solid tumor
malignancy within 5 years prior to Step 2 registration

- History and physical examination within 28 days prior to Step 2 registration

- Karnofsky performance status of >= 70 within 28 days prior to Step 2 registration

- Serum creatinine =< 3 mg/dL (265 umol/L) and creatinine clearance >= 30 ml/min

- Blood urea nitrogen (BUN) within institutional upper limit of normal (e.g. < 20 mg/dL)

- Total bilirubin =< 2.5 mg/dL (43 umol/L)

- Patients may have had prior therapy for brain metastasis, including radiosurgery and
surgical resection; patients must have completed prior therapy by at least 14 days
prior to Step 2 for surgical resection and 7 days for radiosurgery

- Negative serum pregnancy test (in women of childbearing potential) =< 14 days prior to
Step 2; women of childbearing potential and men who are sexually active must practice
adequate contraception while on study

- Patients who are primary English or French speakers are eligible

Exclusion Criteria:

- Prior external beam radiation therapy to the brain or whole brain radiation therapy

- Planned cytotoxic chemotherapy during the WBRT only; patients may have had prior
chemotherapy

- Radiographic evidence of hydrocephalus or other architectural distortion of the
ventricular system, including placement of external ventricular drain or
ventriculoperitoneal shunt

- Severe, active co-morbidity defined as follows:

- Unstable angina and/or congestive heart failure requiring hospitalization within
the last 6 months

- Transmural myocardial infarction within the last 6 months

- Acute bacterial or fungal infection requiring intravenous antibiotics at the time
of registration

- Chronic obstructive pulmonary disease exacerbation or other acute respiratory
illness precluding study therapy at the time of registration

- Severe hepatic disease defined as a diagnosis of Child-Pugh class B or C hepatic
disease

- Renal tubular acidosis or metabolic acidosis

- Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4
count < 200 cells/microliter; note that patients who are HIV positive are
eligible, provided they are under treatment with highly active antiretroviral
therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior
to registration; Note also that HIV testing is not required for eligibility for
this protocol

- Pregnant or lactating women, or women of childbearing potential and men who are
sexually active and not willing/able to use medically acceptable forms of
contraception

- Prior allergic reaction to memantine (memantine hydrochloride)

- Current alcohol or drug abuse (may exacerbate lethargy/dizziness with memantine)

- Intractable seizures while on adequate anticonvulsant therapy—more than 1 seizure per
month for the past 2 months

- Patients with definitive leptomeningeal metastases

- Patients with brain metastases from primary germ cell tumors, small cell carcinoma,
unknown primary, or lymphoma

- Contraindication to magnetic resonance (MR) imaging such as implanted metal devices or
foreign bodies

- Contraindication to gadolinium contrast administration during MR imaging, such as
allergy or insufficient renal function

- Current use of (other N-methyl D-aspartate [NMDA] antagonists) amantadine, ketamine,
or dextromethorphan
LinksPermanent Link to THIS page: http://virtualtrials.com/nct/display1trial.cfm?nct=NCT02360215      |      Link to official Clinicaltrials.gov listing
Locations
Montreal, Quebec
Canada

Facility: CHUM - Hopital Notre-Dame
Investigator: David Roberge
Contact: David Roberge Phone: 514-890-8000
Click HERE to send email to this center

Montreal, Quebec
Canada

Facility: McGill University Department of Oncology
Investigator: David Roberge
Contact: David Roberge Phone: 514-890-8000
Click HERE to send email to this center

Regina, Saskatchewan
Canada

Facility: Allan Blair Cancer Centre
Investigator: Michelle J. Ferguson
Contact: Michelle J. Ferguson Phone: 306-766-2213
Email not avaialable

Saskatoon, Saskatchewan
Canada

Facility: Saskatoon Cancer Centre
Investigator: Vijayananda Kundapur
Contact: Vijayananda Kundapur Phone: 306-655-2914
Email not avaialable

Sioux Falls, South Dakota
United Stat es

Facility: Sanford USD Medical Center - Sioux Falls
Investigator: Preston D. Steen
Contact: Preston D. Steen Phone: 605-328-1367
Email not avaialable

Tuscaloosa, Alabama
Facility: Lewis and Faye Manderson Cancer Center
Investigator: James C. Tucker
Contact: James C. Tucker Phone: 800-338-2948
Email not avaialable

Gilbert, Arizona
Facility: Banner MD Anderson Cancer Center
Investigator: Jing Li
Contact: Jing Li Phone: 602-747-9738
Email not avaialable

Tucson, Arizona
Facility: The University of Arizona Medical Center-University Campus
Investigator: Baldassarre Stea
Contact: Baldassarre Stea Phone: 520-626-9008
Email not avaialable

Burbank, California
Facility: Providence Saint Joseph Medical Center/Disney Family Cancer Center
Investigator: Benjamin B. Bridges
Contact: Benjamin B. Bridges Phone: 818-708-5550
Click HERE to send email to this center

Carmichael, California
Facility: Mercy San Juan Medical Center
Investigator: Ellen A. Wiegner
Contact: Ellen A. Wiegner Phone: 916-537-5237
Email not avaialable

Los Angeles, California
Facility: Kaiser Permanente Los Angeles Medical Center
Investigator: Michael R. Girvigian
Contact: Michael R. Girvigian Phone: 626-564-3455
Email not avaialable

Los Angeles, California
Facility: Los Angeles County-USC Medical Center
Investigator: Eric L. Chang
Contact: Eric L. Chang Phone: 323-865-0451
Email not avaialable

Los Angeles, California
Facility: USC / Norris Comprehensive Cancer Center
Investigator: Eric L. Chang
Contact: Eric L. Chang Phone: 323-865-0451
Email not avaialable

Oakland, California
Facility: Kaiser Permanente Oakland-Broadway
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 510-891-3400
Email not avaialable

Palo Alto, California
Facility: Stanford Cancer Institute Palo Alto
Investigator: Scott G. Soltys
Contact: Scott G. Soltys Phone: 650-498-7061
Click HERE to send email to this center

Rancho Cordova, California
Facility: Kaiser Permanente-Rancho Cordova Cancer Center
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 510-891-3400
Email not avaialable

Rohnert Park, California
Facility: Rohnert Park Cancer Center
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 707-584-2200
Email not avaialable

Roseville, California
Facility: Sutter Cancer Centers Radiation Oncology Services-Roseville
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 415-209-2686
Click HERE to send email to this center

Roseville, California
Facility: The Permanente Medical Group-Roseville Radiation Oncology
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 510-891-3400
Email not avaialable

Sacramento, California
Facility: Mercy Medical Group
Investigator: Ellen A. Wiegner
Contact: Ellen A. Wiegner Phone: 916-537-5237
Email not avaialable

Sacramento, California
Facility: Sutter Medical Center Sacramento
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 415-209-2686
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San Diego, California
Facility: University of California San Diego
Investigator: Jona A. Hattangadi-Gluth
Contact: Jona A. Hattangadi-Gluth
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San Francisco, California
Facility: California Pacific Medical Center-Pacific Campus
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 415-209-2686
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San Jose, California
Facility: Stanford Cancer Center South Bay
Investigator: Scott G. Soltys
Contact: Scott G. Soltys Phone: 650-498-7061
Click HERE to send email to this center

Santa Clara, California
Facility: Kaiser Permanente Medical Center - Santa Clara
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 510-891-3400
Email not avaialable

South San Francisco, California
Facility: Kaiser Permanente Cancer Treatment Center
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 510-891-3400
Email not avaialable

Vallejo, California
Facility: Sutter Solano Medical Center/Cancer Center
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 415-209-2686
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Colorado Springs, Colorado
Facility: Penrose-Saint Francis Healthcare
Investigator: Mehmet S. Copur
Contact: Mehmet S. Copur Phone: 308-398-6518
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Colorado Springs, Colorado
Facility: UCHealth Memorial Hospital Central
Investigator: Chad G. Rusthoven
Contact: Chad G. Rusthoven Phone: 719-365-2406
Email not avaialable

Newark, Delaware
Facility: Helen F Graham Cancer Center
Investigator: Gregory A. Masters
Contact: Gregory A. Masters Phone: 302-733-6227
Email not avaialable

Newark, Delaware
Facility: Christiana Care Health System-Christiana Hospital
Investigator: Gregory A. Masters
Contact: Gregory A. Masters Phone: 302-733-6227
Email not avaialable

Boca Raton, Florida
Facility: Boca Raton Regional Hospital
Investigator: Sajeel A. Chowdhary
Contact: Sajeel A. Chowdhary Phone: 561-955-4800
Email not avaialable

Coral Gables, Florida
Facility: UM Sylvester Comprehensive Cancer Center at Coral Gables
Investigator: Eric A. Mellon
Contact: Eric A. Mellon Phone: 305-243-2647
Email not avaialable

Deerfield Beach, Florida
Facility: UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Investigator: Eric A. Mellon
Contact: Eric A. Mellon Phone: 305-243-2647
Email not avaialable

Miami, Florida
Facility: University of Miami Miller School of Medicine-Sylvester Cancer Center
Investigator: Eric A. Mellon
Contact: Eric A. Mellon Phone: 305-243-2647
Email not avaialable

Weston, Florida
Facility: Cleveland Clinic-Weston
Investigator: Erin S. Murphy
Contact: Erin S. Murphy Phone: 954-659-5705
Email not avaialable

Atlanta, Georgia
Facility: Grady Health System
Investigator: Joseph W. Shelton
Contact: Joseph W. Shelton Phone: 404-489-9164
Email not avaialable

Atlanta, Georgia
Facility: Emory University Hospital Midtown
Investigator: Joseph W. Shelton
Contact: Joseph W. Shelton Phone: 888-946-7447
Email not avaialable

Atlanta, Georgia
Facility: Emory University Hospital/Winship Cancer Institute
Investigator: Joseph W. Shelton
Contact: Joseph W. Shelton Phone: 404-778-1868
Email not avaialable

Atlanta, Georgia
Facility: Emory Saint Joseph's Hospital
Investigator: Joseph W. Shelton
Contact: Joseph W. Shelton Phone: 412-339-5294
Click HERE to send email to this center

Savannah, Georgia
Facility: Memorial University Medical Center
Investigator: Aaron W. Pederson
Contact: Aaron W. Pederson Phone: 912-350-8568
Email not avaialable

Savannah, Georgia
Facility: Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Investigator: Howard A. Zaren
Contact: Howard A. Zaren Phone: 412-339-5294
Click HERE to send email to this center

Boise, Idaho
Facility: Saint Alphonsus Cancer Care Center-Boise
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 734-712-3671
Email not avaialable

Boise, Idaho
Facility: Saint Luke's Mountain States Tumor Institute
Investigator: Benjamin B. Bridges
Contact: Benjamin B. Bridges Phone: 412-339-5294
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Meridian, Idaho
Facility: Saint Luke's Mountain States Tumor Institute - Meridian
Investigator: Benjamin B. Bridges
Contact: Benjamin B. Bridges Phone: 412-339-5294
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Nampa, Idaho
Facility: Saint Luke's Mountain States Tumor Institute - Nampa
Investigator: Benjamin B. Bridges
Contact: Benjamin B. Bridges Phone: 412-339-5294
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Twin Falls, Idaho
Facility: Saint Luke's Mountain States Tumor Institute-Twin Falls
Investigator: Benjamin B. Bridges
Contact: Benjamin B. Bridges Phone: 412-339-5294
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Carterville, Illinois
Facility: SIH Cancer Institute
Investigator: James L. Wade
Contact: James L. Wade Phone: 618-457-5200
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Chicago, Illinois
Facility: Northwestern University
Investigator: Timothy J. Kruser
Contact: Timothy J. Kruser Phone: 312-695-1301
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Chicago, Illinois
Facility: John H Stroger Jr Hospital of Cook County
Investigator: Thomas E. Lad
Contact: Thomas E. Lad Phone: 312-864-6000
Email not avaialable

Chicago, Illinois
Facility: University of Chicago Comprehensive Cancer Center
Investigator: Steven J. Chmura
Contact: Steven J. Chmura Phone: 773-834-7424
Email not avaialable

Decatur, Illinois
Facility: Decatur Memorial Hospital
Investigator: James L. Wade
Contact: James L. Wade Phone: 217-876-6601
Email not avaialable

Effingham, Illinois
Facility: Crossroads Cancer Center
Investigator: James L. Wade
Contact: James L. Wade Phone: 217-342-2066
Email not avaialable

Geneva, Illinois
Facility: Northwestern Medicine Cancer Center Delnor
Investigator: Vinai Gondi
Contact: Vinai Gondi Phone: 630-315-1918
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Libertyville, Illinois
Facility: Condell Memorial Hospital
Investigator: Dean J. Conterato
Contact: Dean J. Conterato Phone: 630-929-6129
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Peoria, Illinois
Facility: Methodist Medical Center of Illinois
Investigator: James L. Wade
Contact: James L. Wade Phone: 309-243-3000
Email not avaialable

Peoria, Illinois
Facility: OSF Saint Francis Medical Center
Investigator: James L. Wade
Contact: James L. Wade Phone: 309-655-3258
Email not avaialable

Urbana, Illinois
Facility: Carle Cancer Center
Investigator: Kalika P. Sarma
Contact: Kalika P. Sarma Phone: 800-446-5532
Email not avaialable

Warrenville, Illinois
Facility: Northwestern Medicine Cancer Center Warrenville
Investigator: Vinai Gondi
Contact: Vinai Gondi Phone: 630-315-1918
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Fort Wayne, Indiana
Facility: Parkview Hospital Randallia
Investigator: Brian K. Chang
Contact: Brian K. Chang Phone: 260-373-8888
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Indianapolis, Indiana
Facility: Community Cancer Center East
Investigator: Daniel W. Weed
Contact: Daniel W. Weed Phone: 317-497-2823
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Indianapolis, Indiana
Facility: Community Cancer Center South
Investigator: Daniel W. Weed
Contact: Daniel W. Weed Phone: 317-497-2823
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Indianapolis, Indiana
Facility: Community Cancer Center North
Investigator: Daniel W. Weed
Contact: Daniel W. Weed Phone: 317-497-2823
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Cedar Rapids, Iowa
Facility: Saint Luke's Hospital
Investigator: Nagendra (Bobby) S. Koneru
Contact: Nagendra (Bobby) S. Koneru Phone: 800-397-2467
Email not avaialable

Kansas City, Kansas
Facility: University of Kansas Cancer Center
Investigator: Joshua M. Mammen
Contact: Joshua M. Mammen Phone: 913-945-7552
Click HERE to send email to this center

Lawrence, Kansas
Facility: Lawrence Memorial Hospital
Investigator: Shaker R. Dakhil
Contact: Shaker R. Dakhil Phone: 316-268-5374
Email not avaialable

Overland Park, Kansas
Facility: University of Kansas Cancer Center-Overland Park
Investigator: Joshua M. Mammen
Contact: Joshua M. Mammen Phone: 913-945-7552
Click HERE to send email to this center

Wichita, Kansas
Facility: Via Christi Regional Medical Center
Investigator: Shaker R. Dakhil
Contact: Shaker R. Dakhil Phone: 800-362-0070
Email not avaialable

Wichita, Kansas
Facility: Wesley Medical Center
Investigator: Shaker R. Dakhil
Contact: Shaker R. Dakhil Phone: 316-962-2920
Email not avaialable

Lexington, Kentucky
Facility: University of Kentucky/Markey Cancer Center
Investigator: Ronald C. McGarry
Contact: Ronald C. McGarry Phone: 859-257-3379
Email not avaialable

New Orleans, Louisiana
Facility: Tulane University Health Sciences Center
Investigator: Steven J. Dibiase
Contact: Steven J. Dibiase Phone: 504-988-6121
Email not avaialable

Baltimore, Maryland
Facility: University of Maryland/Greenebaum Cancer Center
Investigator: Pranshu Mohindra
Contact: Pranshu Mohindra Phone: 800-888-8823
Email not avaialable

Baltimore, Maryland
Facility: MedStar Union Memorial Hospital
Investigator: Paul B. Fowler
Contact: Paul B. Fowler Phone: 410-261-8151
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Bel Air, Maryland
Facility: Upper Chesapeake Medical Center
Investigator: Mark V. Mishra
Contact: Mark V. Mishra Phone: 443-643-3010
Email not avaialable

Columbia, Maryland
Facility: Central Maryland Radiation Oncology in Howard County
Investigator: Pranshu Mohindra
Contact: Pranshu Mohindra Phone: 443-546-1300
Email not avaialable

Glen Burnie, Maryland
Facility: Tate Cancer Center
Investigator: Pranshu Mohindra
Contact: Pranshu Mohindra Phone: 410-553-8100
Email not avaialable

Towson, Maryland
Facility: University of Maryland Saint Joseph Medical Center
Investigator: Jason R. Citron
Contact: Jason R. Citron Phone: 410-337-4569
Click HERE to send email to this center

Burlington, Massachusetts
Facility: Lahey Hospital and Medical Center
Investigator: Klaudia U. Hunter
Contact: Klaudia U. Hunter Phone: 781-744-8027
Email not avaialable

Lowell, Massachusetts
Facility: Lowell General Hospital
Investigator: Matthew S. Katz
Contact: Matthew S. Katz Phone: 978-788-7084
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Ann Arbor, Michigan
Facility: Saint Joseph Mercy Hospital
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 734-712-3671
Email not avaialable

Brownstown, Michigan
Facility: Henry Ford Cancer Institute?Downriver
Investigator: Eleanor M. Walker
Contact: Eleanor M. Walker Phone: 412-339-5294
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Chelsea, Michigan
Facility: Saint Joseph Mercy Chelsea
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 734-712-3671
Email not avaialable

Clarkston, Michigan
Facility: 21st Century Oncology-Clarkston
Investigator: Frank A. Vicini
Contact: Frank A. Vicini Phone: 248-338-0663
Email not avaialable

Clinton Township, Michigan
Facility: Henry Ford Macomb Hospital-Clinton Township
Investigator: Eleanor M. Walker
Contact: Eleanor M. Walker Phone: 313-916-1784
Email not avaialable

Detroit, Michigan
Facility: Wayne State University/Karmanos Cancer Institute
Investigator: Kiran Devisetty
Contact: Kiran Devisetty Phone: 313-576-9363
Email not avaialable

Detroit, Michigan
Facility: Henry Ford Hospital
Investigator: Eleanor M. Walker
Contact: Eleanor M. Walker Phone: 313-916-1784
Email not avaialable

Farmington Hills, Michigan
Facility: 21st Century Oncology-Farmington Hills
Investigator: Frank A. Vicini
Contact: Frank A. Vicini Phone: 248-338-0663
Email not avaialable

Flint, Michigan
Facility: Genesys Hurley Cancer Institute
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 734-712-3671
Email not avaialable

Grand Rapids, Michigan
Facility: Spectrum Health at Butterworth Campus
Investigator: Kathleen J. Yost
Contact: Kathleen J. Yost Phone: 616-391-1230
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Kalamazoo, Michigan
Facility: West Michigan Cancer Center
Investigator: Kathleen J. Yost
Contact: Kathleen J. Yost Phone: 616-391-1230
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Livonia, Michigan
Facility: Saint Mary Mercy Hospital
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 734-712-3671
Email not avaialable

Muskegon, Michigan
Facility: Mercy Health Mercy Campus
Investigator: Kathleen J. Yost
Contact: Kathleen J. Yost Phone: 616-391-1230
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Pontiac, Michigan
Facility: Saint Joseph Mercy Oakland
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 734-712-3671
Email not avaialable

Saint Joseph, Michigan
Facility: Lakeland Hospital
Investigator: Kathleen J. Yost
Contact: Kathleen J. Yost Phone: 616-391-1230
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Troy, Michigan
Facility: 21st Century Oncology-Troy
Investigator: Frank A. Vicini
Contact: Frank A. Vicini Phone: 412-339-5294
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West Bloomfield, Michigan
Facility: Henry Ford West Bloomfield Hospital
Investigator: Eleanor M. Walker
Contact: Eleanor M. Walker Phone: 888-734-5322
Email not avaialable

Albert Lea, Minnesota
Facility: Mayo Clinic Health System in Albert Lea
Investigator: Nadia N. Laack
Contact: Nadia N. Laack Phone: 855-776-0015
Email not avaialable

Fridley, Minnesota
Facility: Unity Hospital
Investigator: Richard A. Peterson
Contact: Richard A. Peterson Phone: 952-993-1517
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Mankato, Minnesota
Facility: Mayo Clinic Health Systems-Mankato
Investigator: Nadia N. Laack
Contact: Nadia N. Laack Phone: 855-776-0015
Email not avaialable

Minneapolis, Minnesota
Facility: Abbott-Northwestern Hospital
Investigator: Richard A. Peterson
Contact: Richard A. Peterson Phone: 952-993-1517
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Northfield, Minnesota
Facility: Mayo Clinic Radiation Therapy-Northfield
Investigator: Nadia N. Laack
Contact: Nadia N. Laack Phone: 855-776-0015
Email not avaialable

Rochester, Minnesota
Facility: Mayo Clinic
Investigator: Nadia N. Laack
Contact: Nadia N. Laack Phone: 855-776-0015
Email not avaialable

Saint Louis Park, Minnesota
Facility: Park Nicollet Clinic - Saint Louis Park
Investigator: Richard A. Peterson
Contact: Richard A. Peterson Phone: 952-993-1517
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Cape Girardeau, Missouri
Facility: Saint Francis Medical Center
Investigator: James L. Wade
Contact: James L. Wade Phone: 573-334-2230
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Creve Coeur, Missouri
Facility: Siteman Cancer Center at West County Hospital
Investigator: Clifford G. Robinson
Contact: Clifford G. Robinson Phone: 800-600-3606
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Kansas City, Missouri
Facility: North Kansas City Hospital
Investigator: Joshua M. Mammen
Contact: Joshua M. Mammen Phone: 816-691-1599
Email not avaialable

Saint Louis, Missouri
Facility: Washington University School of Medicine
Investigator: Clifford G. Robinson
Contact: Clifford G. Robinson Phone: 800-600-3606
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Saint Louis, Missouri
Facility: Siteman Cancer Center-South County
Investigator: Clifford G. Robinson
Contact: Clifford G. Robinson Phone: 800-600-3606
Click HERE to send email to this center

Saint Louis, Missouri
Facility: Missouri Baptist Medical Center
Investigator: James L. Wade
Contact: James L. Wade Phone: 800-392-0936
Email not avaialable

Saint Louis, Missouri
Facility: Mercy Hospital Saint Louis
Investigator: Jay W. Carlson
Contact: Jay W. Carlson Phone: 314-251-6770
Email not avaialable

Saint Peters, Missouri
Facility: Siteman Cancer Center at Saint Peters Hospital
Investigator: Clifford G. Robinson
Contact: Clifford G. Robinson Phone: 800-600-3606
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Springfield, Missouri
Facility: CoxHealth South Hospital
Investigator: Jay W. Carlson
Contact: Jay W. Carlson Phone: 800-821-7532
Email not avaialable

Billings, Montana
Facility: Billings Clinic Cancer Center
Investigator: Benjamin T. Marchello
Contact: Benjamin T. Marchello Phone: 800-996-2663
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Great Falls, Montana
Facility: Benefis Healthcare- Sletten Cancer Institute
Investigator: Benjamin T. Marchello
Contact: Benjamin T. Marchello Phone: 406-969-6060
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Missoula, Montana
Facility: Community Medical Hospital
Investigator: Benjamin T. Marchello
Contact: Benjamin T. Marchello Phone: 406-969-6060
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Omaha, Nebraska
Facility: University of Nebraska Medical Center
Investigator: Andrew O. Wahl
Contact: Andrew O. Wahl Phone: 402-559-6941
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Reno, Nevada
Facility: Renown Regional Medical Center
Investigator: John A. Ellerton
Contact: John A. Ellerton Phone: 702-384-0013
Email not avaialable

Dover, New Hampshire
Facility: Wentworth-Douglass Hospital
Investigator: Arul Mahadevan
Contact: Arul Mahadevan Phone: 603-740-2150
Email not avaialable

Lebanon, New Hampshire
Facility: Dartmouth Hitchcock Medical Center
Investigator: Alan C. Hartford
Contact: Alan C. Hartford Phone: 800-639-6918
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Bronx, New York
Facility: Montefiore Medical Center - Moses Campus
Investigator: William R. Bodner
Contact: William R. Bodner Phone: 718-904-2730
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Brooklyn, New York
Facility: New York-Presbyterian/Brooklyn Methodist Hospital
Investigator: Sameer Rafla-Demetrious
Contact: Sameer Rafla-Demetrious Phone: 718-780-3677
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New York, New York
Facility: Columbia University/Herbert Irving Cancer Center
Investigator: Tony J. Wang
Contact: Tony J. Wang Phone: 212-305-8615
Email not avaialable

Bismarck, North Dakota
Facility: Sanford Bismarck Medical Center
Investigator: Preston D. Steen
Contact: Preston D. Steen Phone: 701-323-5760
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Fargo, North Dakota
Facility: Roger Maris Cancer Center
Investigator: Preston D. Steen
Contact: Preston D. Steen Phone: 701-234-6161
Email not avaialable

Akron, Ohio
Facility: Summa Akron City Hospital/Cooper Cancer Center
Investigator: Desiree E. Doncals
Contact: Desiree E. Doncals Phone: 330-375-6101
Email not avaialable

Akron, Ohio
Facility: Akron General Medical Center
Investigator: Esther H. Rehmus
Contact: Esther H. Rehmus Phone: 330-344-6348
Email not avaialable

Cleveland, Ohio
Facility: Case Western Reserve University
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Cleveland, Ohio
Facility: Cleveland Clinic Cancer Center/Fairview Hospital
Investigator: Erin S. Murphy
Contact: Erin S. Murphy Phone: 216-476-9362
Email not avaialable

Cleveland, Ohio
Facility: Cleveland Clinic Foundation
Investigator: Erin S. Murphy
Contact: Erin S. Murphy Phone: 866-223-8100
Email not avaialable

Columbus, Ohio
Facility: Ohio State University Comprehensive Cancer Center
Investigator: Joshua D. Palmer
Contact: Joshua D. Palmer Phone: 800-293-5066
Click HERE to send email to this center

Independence, Ohio
Facility: Cleveland Clinic Cancer Center Independence
Investigator: Erin S. Murphy
Contact: Erin S. Murphy Phone: 800-544-6333
Email not avaialable

Middleburg Heights, Ohio
Facility: Southwest General Health Center Ireland Cancer Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 440-816-5050
Email not avaialable

Parma, Ohio
Facility: University Hospitals Parma Medical Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 440-743-4747
Email not avaialable

Strongsville, Ohio
Facility: Cleveland Clinic Cancer Center Strongsville
Investigator: Erin S. Murphy
Contact: Erin S. Murphy Phone: 412-339-5294
Click HERE to send email to this center

Westlake, Ohio
Facility: UHHS-Westlake Medical Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 216-844-1374
Email not avaialable

Oklahoma City, Oklahoma
Facility: University of Oklahoma Health Sciences Center
Investigator: Terence S. Herman
Contact: Terence S. Herman Phone: 405-271-8777
Click HERE to send email to this center

Gresham, Oregon
Facility: Legacy Mount Hood Medical Center
Investigator: Andrew Y. Kee
Contact: Andrew Y. Kee Phone: 855-776-0015
Email not avaialable

Portland, Oregon
Facility: Legacy Good Samaritan Hospital and Medical Center
Investigator: Andrew Y. Kee
Contact: Andrew Y. Kee Phone: 855-776-0015
Email not avaialable

Abington, Pennsylvania
Facility: Abington Memorial Hospital
Investigator: Wayne H. Pinover
Contact: Wayne H. Pinover Phone: 215-481-2402
Email not avaialable

Bryn Mawr, Pennsylvania
Facility: Bryn Mawr Hospital
Investigator: Albert S. DeNittis
Contact: Albert S. DeNittis Phone: 484-476-2649
Click HERE to send email to this center

Chadds Ford, Pennsylvania
Facility: Christiana Care Health System-Concord Health Center
Investigator: Gregory A. Masters
Contact: Gregory A. Masters Phone: 302-623-4500
Email not avaialable

Danville, Pennsylvania
Facility: Geisinger Medical Center
Investigator: Anand Mahadevan
Contact: Anand Mahadevan Phone: 570-271-5251
Email not avaialable

Dunmore, Pennsylvania
Facility: Northeast Radiation Oncology Center
Investigator: Wenyin Shi
Contact: Wenyin Shi Phone: 888-808-6762
Email not avaialable

Media, Pennsylvania
Facility: Riddle Memorial Hospital
Investigator: Albert S. DeNittis
Contact: Albert S. DeNittis Phone: 484-476-2649
Click HERE to send email to this center

Philadelphia, Pennsylvania
Facility: NRG Oncology
Investigator: Paul D. Brown
Contact: Paul D. Brown Phone: 713-563-2415
Click HERE to send email to this center

Philadelphia, Pennsylvania
Facility: Thomas Jefferson University Hospital
Investigator: Wenyin Shi
Contact: Wenyin Shi Phone: 215-955-6084
Email not avaialable

Philadelphia, Pennsylvania
Facility: Fox Chase Cancer Center
Investigator: Curtis T. Miyamoto
Contact: Curtis T. Miyamoto Phone: 215-728-4790
Email not avaialable

Philadelphia, Pennsylvania
Facility: Aria Health-Torresdale Campus
Investigator: Wenyin Shi
Contact: Wenyin Shi Phone: 215-612-5296
Email not avaialable

Philadelphia, Pennsylvania
Facility: Temple University Hospital
Investigator: Curtis T. Miyamoto
Contact: Curtis T. Miyamoto Phone: 215-728-2983
Email not avaialable

West Reading, Pennsylvania
Facility: Reading Hospital
Investigator: Terrence P. Cescon
Contact: Terrence P. Cescon Phone: 610-988-9323
Email not avaialable

Wilkes-Barre, Pennsylvania
Facility: Geisinger Wyoming Valley/Henry Cancer Center
Investigator: Anand Mahadevan
Contact: Anand Mahadevan Phone: 570-271-5251
Email not avaialable

Wynnewood, Pennsylvania
Facility: Lankenau Medical Center
Investigator: Albert S. DeNittis
Contact: Albert S. DeNittis Phone: 484-476-2649
Click HERE to send email to this center

Greenville, South Carolina
Facility: Greenville Health System Cancer Institute-Faris
Investigator: David L. Grisell
Contact: David L. Grisell Phone: 864-241-6251
Email not avaialable

Greenville, South Carolina
Facility: Greenville Health System Cancer Institute-Eastside
Investigator: David L. Grisell
Contact: David L. Grisell Phone: 864-679-3966
Email not avaialable

Greenwood, South Carolina
Facility: Self Regional Healthcare
Investigator: Joseph M. Jenrette
Contact: Joseph M. Jenrette Phone: 864-725-4771
Email not avaialable

Hilton Head Island, South Carolina
Facility: The Radiation Oncology Center-Hilton Head/Bluffton
Investigator: Howard A. Zaren
Contact: Howard A. Zaren Phone: 912-819-5704
Email not avaialable

Spartanburg, South Carolina
Facility: Greenville Health System Cancer Institute-Spartanburg
Investigator: David L. Grisell
Contact: David L. Grisell Phone: 864-241-6251
Email not avaialable

Nashville, Tennessee
Facility: Vanderbilt University/Ingram Cancer Center
Investigator: Albert Attia
Contact: Albert Attia Phone: 800-811-8480
Email not avaialable

Galveston, Texas
Facility: University of Texas Medical Branch
Investigator: Todd A. Swanson
Contact: Todd A. Swanson Phone: 409-772-1950
Click HERE to send email to this center

Houston, Texas
Facility: M D Anderson Cancer Center
Investigator: Jing Li
Contact: Jing Li Phone: 713-792-3245
Email not avaialable

League City, Texas
Facility: UTMB Cancer Center at Victory Lakes
Investigator: Todd A. Swanson
Contact: Todd A. Swanson Phone: 800-917-8906
Email not avaialable

Ogden, Utah
Facility: Ogden Regional Medical Center
Investigator: Brandon J. Fisher
Contact: Brandon J. Fisher Phone: 412-339-5294
Click HERE to send email to this center

Saint Johnsbury, Vermont
Facility: Norris Cotton Cancer Center-North
Investigator: Alan C. Hartford
Contact: Alan C. Hartford Phone: 802-473-4100
Email not avaialable

Richmond, Virginia
Facility: Virginia Commonwealth University/Massey Cancer Center
Investigator: Timothy J. Harris
Contact: Timothy J. Harris Phone: 412-339-5294
Click HERE to send email to this center

Seattle, Washington
Facility: Virginia Mason Medical Center
Investigator: John A. Keech
Contact: John A. Keech Phone: 206-342-6954
Click HERE to send email to this center

Yakima, Washington
Facility: North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Investigator: John A. Keech
Contact: John A. Keech Phone: 877-902-3324
Email not avaialable

Morgantown, West Virginia
Facility: West Virginia University Healthcare
Investigator: Malcolm D. Mattes
Contact: Malcolm D. Mattes Phone: 304-293-7374
Click HERE to send email to this center

Antigo, Wisconsin
Facility: Langlade Hospital and Cancer Center
Investigator: Darryl R. Barton
Contact: Darryl R. Barton Phone: 715-623-9869
Click HERE to send email to this center

Eau Claire, Wisconsin
Facility: Mayo Clinic Health System-Eau Claire Clinic
Investigator: Nadia N. Laack
Contact: Nadia N. Laack Phone: 855-776-0015
Email not avaialable

Grafton, Wisconsin
Facility: Aurora Cancer Care-Grafton
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 800-252-2990
Email not avaialable

Green Bay, Wisconsin
Facility: Aurora BayCare Medical Center
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 414-649-5717
Email not avaialable

Johnson Creek, Wisconsin
Facility: UW Cancer Center Johnson Creek
Investigator: Steven P. Howard
Contact: Steven P. Howard Phone: 920-699-3500
Click HERE to send email to this center

Kenosha, Wisconsin
Facility: Aurora Cancer Care-Kenosha South
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 888-709-2080
Email not avaialable

La Crosse, Wisconsin
Facility: Gundersen Lutheran Medical Center
Investigator: Collin D. Driscoll
Contact: Collin D. Driscoll Phone: 608-775-2385
Click HERE to send email to this center

La Crosse, Wisconsin
Facility: Mayo Clinic Health System-Franciscan Healthcare
Investigator: Nadia N. Laack
Contact: Nadia N. Laack Phone: 855-776-0015
Email not avaialable

Madison, Wisconsin
Facility: University of Wisconsin Hospital and Clinics
Investigator: Steven P. Howard
Contact: Steven P. Howard Phone: 800-622-8922
Email not avaialable

Milwaukee, Wisconsin
Facility: Aurora Saint Luke's Medical Center
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 412-339-5294
Click HERE to send email to this center

Milwaukee, Wisconsin
Facility: Froedtert and the Medical College of Wisconsin
Investigator: Joseph A. Bovi
Contact: Joseph A. Bovi Phone: 414-805-4380
Email not avaialable

Milwaukee, Wisconsin
Facility: Aurora Sinai Medical Center
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 414-649-5717
Email not avaialable

Milwaukee, Wisconsin
Facility: Zablocki Veterans Administration Medical Center
Investigator: Elizabeth M. Gore
Contact: Elizabeth M. Gore Phone: 888-469-6614
Email not avaialable

Oshkosh, Wisconsin
Facility: Vince Lombardi Cancer Clinic - Oshkosh
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 800-252-2990
Email not avaialable

Stevens Point, Wisconsin
Facility: Marshfield Clinic Stevens Point Center
Investigator: Patricia K. Lillis
Contact: Patricia K. Lillis Phone: 855-829-8555
Email not avaialable

Summit, Wisconsin
Facility: Aurora Medical Center in Summit
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 800-252-2990
Email not avaialable

Two Rivers, Wisconsin
Facility: Vince Lombardi Cancer Clinic-Two Rivers
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 800-252-2990
Email not avaialable

Wausau, Wisconsin
Facility: Aspirus Regional Cancer Center
Investigator: Darryl R. Barton
Contact: Darryl R. Barton Phone: 877-405-6866
Email not avaialable

West Allis, Wisconsin
Facility: Aurora West Allis Medical Center
Investigator: Ellen L. Ziaja
Contact: Ellen L. Ziaja Phone: 414-328-6000
Email not avaialable

Wisconsin Rapids, Wisconsin
Facility: Aspirus UW Cancer Center
Investigator: Steven P. Howard
Contact: Steven P. Howard Phone: 715-422-7718
Email not avaialable




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