Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02215512 : Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases
PhasePhase 1
AgesMin: 18 Years Max: N/A
Eligibility
Inclusion Criteria:

- Written informed consent

- Age ?18 years

- Eastern Cooperative Oncology Group (ECOG) performance status 0-2

- One or more brain metastases

- Prior radiation therapy to the brain is allowed with the exception of whole brain
irradiation

- Subjects must be neurologically stable for at least 14 days prior to first dose of
study drug;

- Male and female subjects who are not surgically sterile or post-menopausal must agree
to use reliable methods of birth control for the duration of the study and for 90
days after the last dose of study drug administration; male partners of female
subjects should use condoms for the duration of the study, and for 90 days after the
last dose of study drug administration

Exclusion Criteria:

- Pregnant or lactating females

- Any evidence of severe or uncontrolled diseases

- Inadequate bone marrow reserve

- Previous whole brain radiotherapy

- Prior RRx-001 therapy

- Insufficient recovery from all side effects of previous anticancer therapies

- Evidence of blood clotting or bleeding abnormalities
LinksPermanent Link to THIS page: http://virtualtrials.com/nct/display1trial.cfm?nct=NCT02215512      |      Link to official Clinicaltrials.gov listing
Locations
Santa Monica, California
Facility: Providence Saint John's Health Center
Investigator: Santos Kesari, MD, PhD
Contact: Naj Boucher Phone: 310-582-7460
Click HERE to send email to this center

Ann Arbor, Michigan
Facility: University of Michigan
Investigator: Michelle Kim, MD
Contact: Jody Sharp Phone: 734-615-4909
Click HERE to send email to this center

Jackson, Michigan
Facility: Allegiance Health
Investigator: Malcolm Trimble, MD
Contact: Julia Malfeld Phone: 517-841-1413
Click HERE to send email to this center

St Louis, Missouri
Facility: Washington University School of Medicine
Investigator: Christina Tsien, MD
Contact: David Schawb Phone: 314-747-9912
Click HERE to send email to this center

New Brunswick, New Jersey
Facility: The Cancer Institute of New Jersey (Rutgers University)
Investigator: Robert Aiken, MD
Contact: Ling Zheng Phone: 732-235-8865
Click HERE to send email to this center




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