Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT02179086 : Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
PhasePhase 2
AgesMin: 18 Years Max: N/A
Eligibility
Inclusion Criteria:

- PRIOR TO STEP 1 REGISTRATION

- A diagnostic contrast-enhanced magnetic resonance imaging (MRI) (no other scan type
allowed) of the brain must be performed postoperatively within 72 hours of resection;
the enhancing tumor must have a maximal diameter of 5 cm; the tumor diameter will be
the greatest diameter as measured on the contrast-enhanced postoperative MRI and will
include residual disease and/or the postoperative surgical cavity as appropriate; for
cases where residual disease or postoperative surgical cavity is NOT identifiable
(e.g., polar glioblastomas [GBMs] where a polar lobectomy is performed), the patient
will be excluded from the trial

- The GBM tumor must be located in the supratentorial compartment only (any component
involving the brain stem or cerebellum is not allowed)

- Patients must provide study-specific informed consent prior to step 1 registration

- PRIOR TO STEP 2 REGISTRATION

- Histologically proven diagnosis of glioblastoma (World Health Organization [WHO] grade
IV) confirmed by central review prior to step 2 registration

- Tumor tissue that is determined by central pathology review prior to step 2
registration to be of sufficient quantity for analysis of
O6-methylguanin-DNA-methyltransferase (MGMT) status

- Patients must have at least 1 block of tumor tissue; submission of 2 blocks is
strongly encouraged to maximize the chances of eligibility; at least 1 cubic
centimeter of tissue composed primarily of tumor must be present

- Diagnosis must be made by surgical excision, either partial or complete;
stereotactic biopsy or cavitron ultrasonic suction aspirator (CUSA) technique are
not allowed

- History/physical examination within 28 days prior to step 2 registration

- The patient must have recovered from effects of surgery, postoperative infection, and
other complications within 28 days prior to step 2 registration

- Documentation of steroid doses within 28 days prior to step 2 registration

- Karnofsky performance status >= 70 within 28 days prior to step 2 registration

- Age >= 18

- Absolute neutrophil count (ANC) >= 1,800 cells/mm^3

- Platelets >= 100,000 cells/mm^3

- Hemoglobin >= 10.0 g/dl (note: the use of transfusion or other intervention to achieve
hemoglobin (Hgb) >= 10.0 g/dl is acceptable)

- Bilirubin =< 1.5 upper limit of normal (ULN)

- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN

- Negative serum pregnancy test obtained for females of child-bearing potential within
28 days prior to step 2 registration

Exclusion Criteria:

- Prior invasive malignancy (except non-melanomatous skin cancer) unless disease-free
for a minimum of 3 years; (for example, carcinoma in situ of the breast, oral cavity,
or cervix are all permissible)

- Recurrent or multifocal malignant gliomas

- Any site of distant disease (for example, drop metastases from the GBM tumor site)

- Prior chemotherapy or radiosensitizers for cancers of the head and neck region; note
that prior chemotherapy for a different cancer is allowable (except temozolomide)

- Prior use of Gliadel wafers or any other intratumoral or intracavitary treatment are
not permitted

- Prior radiotherapy to the head or neck (except for T1 glottic cancer), resulting in
overlap of radiation fields

- Severe, active co-morbidity, defined as follows:

- Unstable angina at step 2 registration

- Transmural myocardial infarction within the last 6 months prior to step 2
registration

- Evidence of recent myocardial infarction or ischemia by the findings of S-T
elevations of >= 2 mm using the analysis of an electrocardiogram (EKG) performed
within 28 days prior to step 2 registration

- New York Heart Association grade II or greater congestive heart failure requiring
hospitalization within 12 months prior to step 2 registration

- Serious and inadequately controlled arrhythmia at step 2 registration

- Serious or non-healing wound, ulcer or bone fracture or history of abdominal
fistula, intra-abdominal abscess requiring major surgical procedure, open biopsy
or significant traumatic injury within 28 days prior to step 2 registration, with
the exception of the craniotomy for surgical resection

- Acute bacterial or fungal infection requiring intravenous antibiotics at the time
of step 2 registration

- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects;
note, however, that laboratory tests for coagulation parameters are not required
for entry into this protocol

- Chronic obstructive pulmonary disease exacerbation or other respiratory illness
requiring hospitalization or precluding study therapy at the time of step 2
registration

- Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease
Control and Prevention (CDC) definition; note, however, that human
immunodeficiency virus (HIV) testing is not required for entry into this protocol

- Any other severe immunocompromised condition

- Active connective tissue disorders, such as lupus or scleroderma, that in the
opinion of the treating physician may put the patient at high risk for radiation
toxicity

- End-stage renal disease (ie, on dialysis or dialysis has been recommended)

- Any other major medical illnesses or psychiatric treatments that in the
investigator's opinion will prevent administration or completion of protocol
therapy

- Pregnancy or women of childbearing potential and men who are sexually active and not
willing/able to use medically acceptable forms of contraception

- Patents treated on any other therapeutic clinical protocols within 30 days prior to
step 2 registration

- Inability to undergo MRI (e.g., due to safety reasons, such as presence of a
pacemaker, or severe claustrophobia)

- Postoperative tumor plus surgical bed size exceeds 5 cm in maximum diameter.
LinksPermanent Link to THIS page: http://virtualtrials.com/nct/display1trial.cfm?nct=NCT02179086      |      Link to official Clinicaltrials.gov listing
Locations
Victoria, British Columbia
Canada

Facility: BCCA-Vancouver Island Cancer Centre
Investigator: Abraham S. Alexander
Contact: Abraham S. Alexander Phone: 604-877-6010
Email not avaialable

Ottawa, Ontario
Canada

Facility: Ottawa Hospital and Cancer Center-General Campus
Investigator: Jean-Michel Caudrelier
Contact: Jean-Michel Caudrelier Phone: 613-761-4395
Email not avaialable

Montreal, Quebec
Canada

Facility: CHUM - Hopital Notre-Dame
Investigator: Jean-Paul Bahary
Contact: Jean-Paul Bahary Phone: 514-890-8000
Click HERE to send email to this center

Montreal, Quebec
Canada

Facility: The Research Institute of the McGill University Health Centre (MUHC)
Investigator: Valerie Panet-Raymond
Contact: Valerie Panet-Raymond Phone: 514-934-1934
Click HERE to send email to this center

Phoenix, Arizona
Facility: Saint Joseph's Hospital and Medical Center
Investigator: David G. Brachman
Contact: David G. Brachman Phone: 800-360-6371
Email not avaialable

Tucson, Arizona
Facility: The University of Arizona Medical Center-University Campus
Investigator: Baldassarre Stea
Contact: Baldassarre Stea Phone: 520-626-9008
Email not avaialable

Little Rock, Arkansas
Facility: University of Arkansas for Medical Sciences
Investigator: Sanjay Maraboyina
Contact: Sanjay Maraboyina Phone: 501-686-8274
Email not avaialable

Auburn, California
Facility: Sutter Cancer Centers Radiation Oncology Services-Auburn
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Bakersfield, California
Facility: AIS Cancer Center at San Joaquin Community Hospital
Investigator: Ruben C. Fragoso
Contact: Ruben C. Fragoso Phone: 916-734-3089
Email not avaialable

Berkeley, California
Facility: Alta Bates Summit Medical Center-Herrick Campus
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Cameron Park, California
Facility: Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Castro Valley, California
Facility: Eden Hospital Medical Center
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Loma Linda, California
Facility: Loma Linda University Medical Center
Investigator: Joseph I. Kang
Contact: Joseph I. Kang Phone: 909-558-3375
Email not avaialable

Los Angeles, California
Facility: Los Angeles County-USC Medical Center
Investigator: Richard L. Jennelle
Contact: Richard L. Jennelle Phone: 323-865-0451
Email not avaialable

Los Angeles, California
Facility: USC / Norris Comprehensive Cancer Center
Investigator: Richard L. Jennelle
Contact: Richard L. Jennelle Phone: 323-865-0451
Email not avaialable

Los Angeles, California
Facility: Cedars Sinai Medical Center
Investigator: Stephen L. Shiao
Contact: Stephen L. Shiao Phone: 310-423-8965
Email not avaialable

Marysville, California
Facility: Fremont - Rideout Cancer Center
Investigator: Ruben C. Fragoso
Contact: Ruben C. Fragoso Phone: 916-734-3089
Email not avaialable

Oakland, California
Facility: Kaiser Permanente Oakland-Broadway
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 877-827-3222
Email not avaialable

Orange, California
Facility: UC Irvine Health/Chao Family Comprehensive Cancer Center
Investigator: Xiao-Tang Kong
Contact: Xiao-Tang Kong Phone: 877-827-8839
Click HERE to send email to this center

Palo Alto, California
Facility: Palo Alto Medical Foundation Health Care
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Pomona, California
Facility: Pomona Valley Hospital Medical Center
Investigator: Yallapragada S. Rao
Contact: Yallapragada S. Rao Phone: 909-865-9555
Email not avaialable

Rancho Cordova, California
Facility: Kaiser Permanente-Rancho Cordova Cancer Center
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 877-827-3222
Email not avaialable

Rohnert Park, California
Facility: Rohnert Park Cancer Center
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 877-827-3222
Email not avaialable

Roseville, California
Facility: Sutter Cancer Centers Radiation Oncology Services-Roseville
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Roseville, California
Facility: The Permanente Medical Group-Roseville Radiation Oncology
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 877-827-3222
Email not avaialable

Sacramento, California
Facility: Sutter Medical Center Sacramento
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Sacramento, California
Facility: University of California Davis Comprehensive Cancer Center
Investigator: Ruben C. Fragoso
Contact: Ruben C. Fragoso Phone: 916-734-3089
Email not avaialable

Sacramento, California
Facility: South Sacramento Cancer Center
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 877-827-3222
Email not avaialable

San Francisco, California
Facility: California Pacific Medical Center-Pacific Campus
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Santa Cruz, California
Facility: Palo Alto Medical Foundation-Santa Cruz
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

South San Francisco, California
Facility: Kaiser Permanente Cancer Treatment Center
Investigator: Samantha A. Seaward
Contact: Samantha A. Seaward Phone: 877-827-3222
Email not avaialable

Sunnyvale, California
Facility: Palo Alto Medical Foundation-Sunnyvale
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Vacaville, California
Facility: Sutter Cancer Centers Radiation Oncology Services-Vacaville
Investigator: Christopher U. Jones
Contact: Christopher U. Jones Phone: 916-537-5237
Email not avaialable

Colorado Springs, Colorado
Facility: Memorial Hospital Central
Investigator: Anthony D. Elias
Contact: Anthony D. Elias Phone: 970-297-6150
Email not avaialable

Fort Collins, Colorado
Facility: Poudre Valley Hospital
Investigator: Anthony D. Elias
Contact: Anthony D. Elias Phone: 970-297-6150
Email not avaialable

Boca Raton, Florida
Facility: Boca Raton Regional Hospital
Investigator: Sajeel A. Chowdhary
Contact: Sajeel A. Chowdhary Phone: 561-955-4800
Email not avaialable

Jacksonville, Florida
Facility: University of Florida Health Science Center
Investigator: Ronny L. Rotondo
Contact: Ronny L. Rotondo Phone: 888-254-7581
Email not avaialable

Atlanta, Georgia
Facility: Emory University/Winship Cancer Institute
Investigator: Hui-Kuo G. Shu
Contact: Hui-Kuo G. Shu Phone: 404-778-1868
Email not avaialable

Savannah, Georgia
Facility: Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Investigator: Howard A. Zaren
Contact: Howard A. Zaren Phone: 912-819-5704
Email not avaialable

Boise, Idaho
Facility: Saint Alphonsus Cancer Care Center-Boise
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 208-367-7954
Email not avaialable

Chicago, Illinois
Facility: Northwestern University
Investigator: Timothy J. Kruser
Contact: Timothy J. Kruser Phone: 312-695-1301
Click HERE to send email to this center

Chicago, Illinois
Facility: John H Stroger Jr Hospital of Cook County
Investigator: Thomas E. Lad
Contact: Thomas E. Lad Phone: 312-864-6000
Email not avaialable

Chicago, Illinois
Facility: University of Chicago Comprehensive Cancer Center
Investigator: Steven J. Chmura
Contact: Steven J. Chmura Phone: 312-355-3046
Email not avaialable

Decatur, Illinois
Facility: Decatur Memorial Hospital
Investigator: James L. Wade
Contact: James L. Wade Phone: 309-243-3605
Email not avaialable

Geneva, Illinois
Facility: Northwestern Medicine Cancer Center Delnor
Investigator: Vinai Gondi
Contact: Vinai Gondi Phone: 630-315-1918
Click HERE to send email to this center

New Lenox, Illinois
Facility: UC Comprehensive Cancer Center at Silver Cross
Investigator: Steven J. Chmura
Contact: Steven J. Chmura Phone: 312-355-3046
Email not avaialable

Peoria, Illinois
Facility: OSF Saint Francis Medical Center
Investigator: James L. Wade
Contact: James L. Wade Phone: 309-243-3605
Email not avaialable

Warrenville, Illinois
Facility: Northwestern Medicine Cancer Center Warrenville
Investigator: Vinai Gondi
Contact: Vinai Gondi Phone: 630-315-1918
Click HERE to send email to this center

Fort Wayne, Indiana
Facility: Radiation Oncology Associates PC
Investigator: Brian K. Chang
Contact: Brian K. Chang Phone: 260-373-8888
Click HERE to send email to this center

Fort Wayne, Indiana
Facility: Parkview Hospital Randallia
Investigator: Brian K. Chang
Contact: Brian K. Chang Phone: 260-373-8888
Click HERE to send email to this center

Indianapolis, Indiana
Facility: IU Health Methodist Hospital
Investigator: Kevin P. McMullen
Contact: Kevin P. McMullen Phone: 317-962-5731
Email not avaialable

Kansas City, Kansas
Facility: University of Kansas Cancer Center
Investigator: Joshua M. Mammen
Contact: Joshua M. Mammen Phone: 913-945-7552
Click HERE to send email to this center

Overland Park, Kansas
Facility: University of Kansas Cancer Center-Overland Park
Investigator: Joshua M. Mammen
Contact: Joshua M. Mammen Phone: 913-945-7552
Click HERE to send email to this center

Baltimore, Maryland
Facility: Maryland Proton Treatment Center
Investigator: Mark V. Mishra
Contact: Mark V. Mishra Phone: 800-888-8823
Email not avaialable

Baltimore, Maryland
Facility: University of Maryland/Greenebaum Cancer Center
Investigator: Mark V. Mishra
Contact: Mark V. Mishra Phone: 800-888-8823
Email not avaialable

Bel Air, Maryland
Facility: Upper Chesapeake Medical Center
Investigator: Mark V. Mishra
Contact: Mark V. Mishra Phone: 800-888-8823
Email not avaialable

Columbia, Maryland
Facility: Central Maryland Radiation Oncology in Howard County
Investigator: Mark V. Mishra
Contact: Mark V. Mishra Phone: 800-888-8823
Email not avaialable

Glen Burnie, Maryland
Facility: Tate Cancer Center
Investigator: Mark V. Mishra
Contact: Mark V. Mishra Phone: 800-888-8823
Email not avaialable

Boston, Massachusetts
Facility: Tufts Medical Center
Investigator: John E. Mignano
Contact: John E. Mignano Phone: 617-636-5000
Click HERE to send email to this center

Boston, Massachusetts
Facility: Massachusetts General Hospital Cancer Center
Investigator: Helen A. Shih
Contact: Helen A. Shih Phone: 877-726-5130
Email not avaialable

Danvers, Massachusetts
Facility: Mass General/North Shore Cancer Center
Investigator: Helen A. Shih
Contact: Helen A. Shih Phone: 877-726-5130
Email not avaialable

Ann Arbor, Michigan
Facility: Saint Joseph Mercy Hospital
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 208-367-7954
Email not avaialable

Ann Arbor, Michigan
Facility: University of Michigan Comprehensive Cancer Center
Investigator: Daniel E. Spratt
Contact: Daniel E. Spratt Phone: 800-865-1125
Email not avaialable

Livonia, Michigan
Facility: Saint Mary Mercy Hospital
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 208-367-7954
Email not avaialable

Pontiac, Michigan
Facility: Saint Joseph Mercy Oakland
Investigator: Samir Narayan
Contact: Samir Narayan Phone: 208-367-7954
Email not avaialable

Bemidji, Minnesota
Facility: Sanford Clinic North-Bemidgi
Investigator: Preston D. Steen
Contact: Preston D. Steen Phone: 712-252-0088
Email not avaialable

Duluth, Minnesota
Facility: Saint Luke's Hospital of Duluth
Investigator: Steven R. Bonin
Contact: Steven R. Bonin Phone: 412-339-5294
Click HERE to send email to this center

Saint Cloud, Minnesota
Facility: Coborn Cancer Center at Saint Cloud Hospital
Investigator: Donald J. Jurgens
Contact: Donald J. Jurgens Phone: 877-229-4907
Email not avaialable

Kansas City, Missouri
Facility: North Kansas City Hospital
Investigator: Joshua M. Mammen
Contact: Joshua M. Mammen Phone: 913-945-7552
Click HERE to send email to this center

Kansas City, Missouri
Facility: The University of Kansas Cancer Center-North
Investigator: Joshua M. Mammen
Contact: Joshua M. Mammen Phone: 913-945-7552
Click HERE to send email to this center

Saint Louis, Missouri
Facility: Washington University School of Medicine
Investigator: Jiayi Huang
Contact: Jiayi Huang Phone: 800-600-3606
Click HERE to send email to this center

Reno, Nevada
Facility: Renown Regional Medical Center
Investigator: John A. Ellerton
Contact: John A. Ellerton Phone: 805-474-9143
Email not avaialable

Reno, Nevada
Facility: Saint Mary's Regional Medical Center
Investigator: John A. Ellerton
Contact: John A. Ellerton Phone: 805-474-9143
Email not avaialable

Basking Ridge, New Jersey
Facility: Memorial Sloan Kettering Basking Ridge
Investigator: Mariza Daras
Contact: Mariza Daras Phone: 212-639-7202
Email not avaialable

New Brunswick, New Jersey
Facility: Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
Investigator: Atif J. Khan
Contact: Atif J. Khan Phone: 412-339-5294
Click HERE to send email to this center

New Brunswick, New Jersey
Facility: Rutgers Cancer Institute of New Jersey
Investigator: Atif J. Khan
Contact: Atif J. Khan Phone: 412-339-5294
Click HERE to send email to this center

Pennington, New Jersey
Facility: Capital Health Medical Center-Hopewell
Investigator: Shirnett K. Williamson
Contact: Shirnett K. Williamson Phone: 800-255-3440
Email not avaialable

Brooklyn, New York
Facility: New York-Presbyterian/Brooklyn Methodist Hospital
Investigator: Sameer Rafla-Demetrious
Contact: Sameer Rafla-Demetrious Phone: 718-780-3677
Click HERE to send email to this center

Commack, New York
Facility: Memorial Sloan Kettering Commack
Investigator: Mariza Daras
Contact: Mariza Daras Phone: 212-639-7202
Email not avaialable

Harrison, New York
Facility: Memorial Sloan Kettering Westchester
Investigator: Mariza Daras
Contact: Mariza Daras Phone: 212-639-7202
Email not avaialable

New York, New York
Facility: Memorial Sloan-Kettering Cancer Center
Investigator: Mariza Daras
Contact: Mariza Daras Phone: 212-639-7202
Email not avaialable

Asheville, North Carolina
Facility: Mission Hospital-Memorial Campus
Investigator: Christopher H. Chay
Contact: Christopher H. Chay Phone: 828-213-4150
Email not avaialable

Bismarck, North Dakota
Facility: Sanford Bismarck Medical Center
Investigator: Preston D. Steen
Contact: Preston D. Steen Phone: 712-252-0088
Email not avaialable

Fargo, North Dakota
Facility: Roger Maris Cancer Center
Investigator: Preston D. Steen
Contact: Preston D. Steen Phone: 712-252-0088
Email not avaialable

Akron, Ohio
Facility: Akron General Medical Center
Investigator: Mitchel L. Fromm
Contact: Mitchel L. Fromm Phone: 330-344-6348
Email not avaialable

Beachwood, Ohio
Facility: UHHS-Chagrin Highlands Medical Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Chardon, Ohio
Facility: Geaugra Hospital
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Cincinnati, Ohio
Facility: University of Cincinnati/Barrett Cancer Center
Investigator: Kevin P. Redmond
Contact: Kevin P. Redmond Phone: 513-558-4553
Click HERE to send email to this center

Cleveland, Ohio
Facility: Case Western Reserve University
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Cleveland, Ohio
Facility: Cleveland Clinic Cancer Center/Fairview Hospital
Investigator: Samuel T. Chao
Contact: Samuel T. Chao Phone: 866-223-8100
Email not avaialable

Cleveland, Ohio
Facility: Cleveland Clinic Foundation
Investigator: Samuel T. Chao
Contact: Samuel T. Chao Phone: 866-223-8100
Email not avaialable

Columbus, Ohio
Facility: Ohio State University Comprehensive Cancer Center
Investigator: Arnab Chakravarti
Contact: Arnab Chakravarti Phone: 800-293-5066
Click HERE to send email to this center

Elyria, Ohio
Facility: Mercy Cancer Center-Elyria
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Independence, Ohio
Facility: Cleveland Clinic Cancer Center Independence
Investigator: Samuel T. Chao
Contact: Samuel T. Chao Phone: 866-223-8100
Email not avaialable

Mayfield Heights, Ohio
Facility: Hillcrest Hospital Cancer Center
Investigator: Samuel T. Chao
Contact: Samuel T. Chao Phone: 866-223-8100
Email not avaialable

Mentor, Ohio
Facility: Lake University Ireland Cancer Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Middleburg Heights, Ohio
Facility: Southwest General Health Center Ireland Cancer Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Parma, Ohio
Facility: University Hospitals Parma Medical Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Sandusky, Ohio
Facility: Ireland Cancer Center at Firelands Regional Medical Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Sandusky, Ohio
Facility: North Coast Cancer Care
Investigator: Samuel T. Chao
Contact: Samuel T. Chao Phone: 866-223-8100
Email not avaialable

Strongsville, Ohio
Facility: Cleveland Clinic Cancer Center Strongsville
Investigator: Samuel T. Chao
Contact: Samuel T. Chao Phone: 866-223-8100
Email not avaialable

Toledo, Ohio
Facility: University of Toledo
Investigator: Krishna Reddy
Contact: Krishna Reddy Phone: 419-383-6583
Email not avaialable

West Chester, Ohio
Facility: University Pointe
Investigator: Kevin P. Redmond
Contact: Kevin P. Redmond Phone: 513-558-4553
Click HERE to send email to this center

Westlake, Ohio
Facility: UHHS-Westlake Medical Center
Investigator: Mitchell Machtay
Contact: Mitchell Machtay Phone: 800-641-2422
Email not avaialable

Wooster, Ohio
Facility: Cleveland Clinic Wooster Family Health and Surgery Center
Investigator: Samuel T. Chao
Contact: Samuel T. Chao Phone: 866-223-8100
Email not avaialable

Oklahoma City, Oklahoma
Facility: University of Oklahoma Health Sciences Center
Investigator: Terence S. Herman
Contact: Terence S. Herman Phone: 405-271-8777
Click HERE to send email to this center

Portland, Oregon
Facility: Legacy Good Samaritan Hospital and Medical Center
Investigator: Andrew Y. Kee
Contact: Andrew Y. Kee Phone: 855-776-0015
Email not avaialable

Bethlehem, Pennsylvania
Facility: Saint Luke's University Hospital-Bethlehem Campus
Investigator: Nimisha Deb
Contact: Nimisha Deb Phone: 412-339-5294
Click HERE to send email to this center

Dunmore, Pennsylvania
Facility: Northeast Radiation Oncology Center
Investigator: Wenyin Shi
Contact: Wenyin Shi Phone: 215-955-6084
Email not avaialable

Gettysburg, Pennsylvania
Facility: Adams Cancer Center
Investigator: Amit B. Shah
Contact: Amit B. Shah Phone: 877-441-7957
Email not avaialable

Harrisburg, Pennsylvania
Facility: PinnacleHealth Cancer Center-Community Campus
Investigator: David C. Weksberg
Contact: David C. Weksberg Phone: 717-724-6765
Click HERE to send email to this center

Philadelphia, Pennsylvania
Facility: Thomas Jefferson University Hospital
Investigator: Wenyin Shi
Contact: Wenyin Shi Phone: 215-955-6084
Email not avaialable

Philadelphia, Pennsylvania
Facility: Aria Health-Torresdale Campus
Investigator: Wenyin Shi
Contact: Wenyin Shi Phone: 215-955-6084
Email not avaialable

West Reading, Pennsylvania
Facility: Reading Hospital
Investigator: Terrence P. Cescon
Contact: Terrence P. Cescon Phone: 610-988-9323
Email not avaialable

York, Pennsylvania
Facility: WellSpan Health-York Cancer Center
Investigator: Amit B. Shah
Contact: Amit B. Shah Phone: 877-441-7957
Email not avaialable

Greenville, South Carolina
Facility: Greenville Health System Cancer Institute-Faris
Investigator: David L. Grisell
Contact: David L. Grisell Phone: 864-679-3966
Email not avaialable

Greenville, South Carolina
Facility: Greenville Health System Cancer Institute-Eastside
Investigator: David L. Grisell
Contact: David L. Grisell Phone: 864-679-3966
Email not avaialable

Greer, South Carolina
Facility: Greenville Health System Cancer Institute-Greer
Investigator: David L. Grisell
Contact: David L. Grisell Phone: 864-679-3966
Email not avaialable

Seneca, South Carolina
Facility: Greenville Health System Cancer Institute-Seneca
Investigator: David L. Grisell
Contact: David L. Grisell Phone: 864-679-3966
Email not avaialable

Spartanburg, South Carolina
Facility: Greenville Health System Cancer Institute-Spartanburg
Investigator: David L. Grisell
Contact: David L. Grisell Phone: 864-679-3966
Email not avaialable

Sioux Falls, South Dakota
Facility: Sanford USD Medical Center - Sioux Falls
Investigator: Preston D. Steen
Contact: Preston D. Steen Phone: 712-252-0088
Email not avaialable

Knoxville, Tennessee
Facility: Tennessee Cancer Specialists-Dowell Springs
Investigator: J. B. Wilkinson
Contact: J. B. Wilkinson Phone: 865-244-3209
Email not avaialable

Austin, Texas
Facility: Texas Oncology-Austin Midtown
Investigator: Vivek S. Kavadi
Contact: Vivek S. Kavadi Phone: 913-945-7552
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Austin, Texas
Facility: Texas Oncology - Central Austin Cancer Center
Investigator: Vivek S. Kavadi
Contact: Vivek S. Kavadi Phone: 913-945-7552
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Austin, Texas
Facility: Texas Oncology - South Austin Cancer Center
Investigator: Vivek S. Kavadi
Contact: Vivek S. Kavadi Phone: 913-945-7552
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Dallas, Texas
Facility: UT Southwestern/Simmons Cancer Center-Dallas
Investigator: Robert D. Timmerman
Contact: Robert D. Timmerman Phone: 214-590-5582
Email not avaialable

Flower Mound, Texas
Facility: Texas Oncology-Flower Mound
Investigator: Vivek S. Kavadi
Contact: Vivek S. Kavadi Phone: 913-945-7552
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Houston, Texas
Facility: M D Anderson Cancer Center
Investigator: Andrew J. Bishop
Contact: Andrew J. Bishop Phone: 713-792-3245
Email not avaialable

Lubbock, Texas
Facility: Covenant Medical Center-Lakeside
Investigator: Paul J. Anderson
Contact: Paul J. Anderson Phone: 806-725-8000
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Round Rock, Texas
Facility: Texas Oncology - Round Rock Cancer Center
Investigator: Vivek S. Kavadi
Contact: Vivek S. Kavadi Phone: 913-945-7552
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San Antonio, Texas
Facility: University of Texas Health Science Center at San Antonio
Investigator: Richard L. Crownover
Contact: Richard L. Crownover Phone: 210-450-3800
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Sherman, Texas
Facility: Texas Cancer Center-Sherman
Investigator: Vivek S. Kavadi
Contact: Vivek S. Kavadi Phone: 913-945-7552
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Tyler, Texas
Facility: Tyler Cancer Center
Investigator: Vivek S. Kavadi
Contact: Vivek S. Kavadi Phone: 913-945-7552
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Salt Lake City, Utah
Facility: Huntsman Cancer Institute/University of Utah
Investigator: Dennis C. Shrieve
Contact: Dennis C. Shrieve Phone: 801-581-4477
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Berlin Corners, Vermont
Facility: Central Vermont Medical Center/National Life Cancer Treatment
Investigator: Carl J. Nelson
Contact: Carl J. Nelson Phone: 802-656-4101
Email not avaialable

Burlington, Vermont
Facility: University of Vermont Medical Center
Investigator: Carl J. Nelson
Contact: Carl J. Nelson Phone: 802-656-4101
Email not avaialable

Seattle, Washington
Facility: Seattle Cancer Care Alliance at Northwest Hospital
Investigator: Lia M. Halasz
Contact: Lia M. Halasz Phone: 800-422-6237
Email not avaialable

Seattle, Washington
Facility: University of Washington Medical Center
Investigator: Lia M. Halasz
Contact: Lia M. Halasz Phone: 800-422-6237
Email not avaialable

Vancouver, Washington
Facility: Compass Oncology Vancouver
Investigator: Vivek S. Kavadi
Contact: Vivek S. Kavadi Phone: 913-945-7552
Click HERE to send email to this center

Wheeling, West Virginia
Facility: Wheeling Hospital/Schiffler Cancer Center
Investigator: Jondavid Pollock
Contact: Jondavid Pollock Phone: 304-243-6442
Email not avaialable

La Crosse, Wisconsin
Facility: Gundersen Lutheran Medical Center
Investigator: Collin D. Driscoll
Contact: Collin D. Driscoll Phone: 608-775-2385
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Menomonee Falls, Wisconsin
Facility: Community Memorial Hospital
Investigator: Joseph A. Bovi
Contact: Joseph A. Bovi Phone: 414-805-4380
Email not avaialable

Milwaukee, Wisconsin
Facility: Froedtert and the Medical College of Wisconsin
Investigator: Joseph A. Bovi
Contact: Joseph A. Bovi Phone: 414-805-4380
Email not avaialable

Wisconsin Rapids, Wisconsin
Facility: Aspirus UW Cancer Center
Investigator: Darryl R. Barton
Contact: Darryl R. Barton Phone: 877-405-6866
Email not avaialable




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