Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT01800695 : Evaluating the Safety and Pharmacokinetics of ABT-414 for Subjects With Glioblastoma Multiforme
PhasePhase 1
AgesMin: 18 Years Max: 99 Years
Eligibility
Inclusion Criteria:

1. Glioblastoma Multiforme (GBM)

2. 70 or above on Karnofsky Performance Status

3. Adequate bone marrow function

4. Recurrent GBM per RANO criteria

5. Subjects must have confirmed EGFR amplification by central lab

Exclusion Criteria:

1. For Subjects with recurrent GBM in Arm B, subject has received prior treatment with
bevacizumab, nitrosourea, or has secondary GBM

2. For Subjects with recurrent GBM in Arm C, subject has received prior treatment with
bevacizumab, or has secondary GBM

3. Allergies to temozolomide, dacarbazine, IgG containing agents

4. Anti-cancer treatment 28 days prior to study Day 1, except in Arm B expanded cohort
temozolomide therapy is allowed

5. Subjects that have had more than one disease recurrence
LinksPermanent Link to THIS page: http://virtualtrials.com/nct/display1trial.cfm?nct=NCT01800695      |      Link to official Clinicaltrials.gov listing
Locations
Brisbane,
Australia

Facility: Site Reference ID/Investigator# 133368
Investigator: Site Reference ID/Investigator# 133368, MD
Contact:
Email not avaialable

Camperdown,
Australia

Facility: Site Reference ID/Investigator# 133028
Investigator: Site Reference ID/Investigator# 133028, MD
Contact:
Email not avaialable

Heidelberg,
Australia

Facility: Site Reference ID/Investigator# 90833
Investigator: Site Reference ID/Investigator# 90833, MD
Contact:
Email not avaialable

St. Leonards,
Australia

Facility: Site Reference ID/Investigator# 132912
Investigator: Site Reference ID/Investigator# 132912, MD DO
Contact:
Email not avaialable

Westmead,
Australia

Facility: Site Reference ID/Investigator# 136172
Investigator: Site Reference ID/Investigator# 136172, MD
Contact:
Email not avaialable

Rotterdam,
Netherlands

Facility: Site Reference ID/Investigator# 92294
Investigator: Site Reference ID/Investigator# 92294, MD
Contact:
Email not avaialable

Birmingham, Alabama
Facility: Site Reference ID/Investigator# 131879
Investigator: Site Reference ID/Investigator# 131879, MD
Contact:
Email not avaialable

Los Angeles, California
Facility: Site Reference ID/Investigator# 137975
Investigator: Site Reference ID/Investigator# 137975, MD
Contact:
Email not avaialable

San Francisco, California
Facility: Site Reference ID/Investigator# 129969
Investigator: Site Reference ID/Investigator# 129969, MD
Contact:
Email not avaialable

Chicago, Illinois
Facility: Site Reference ID/Investigator# 106817
Investigator: Site Reference ID/Investigator# 106817, MD
Contact:
Email not avaialable

Evanston, Illinois
Facility: Site Reference ID/Investigator# 106816
Investigator: Site Reference ID/Investigator# 106816, MD
Contact:
Email not avaialable

Boston, Massachusetts
Facility: Site Reference ID/Investigator# 127615
Investigator: Site Reference ID/Investigator# 127615, MD
Contact:
Email not avaialable

Boston, Massachusetts
Facility: Site Reference ID/Investigator# 95737
Investigator: Site Reference ID/Investigator# 95737, MD
Contact:
Email not avaialable

Detroit, Michigan
Facility: Site Reference ID/Investigator# 133570
Investigator: Site Reference ID/Investigator# 133570, MD
Contact:
Email not avaialable

New York, New York
Facility: Site Reference ID/Investigator# 92313
Investigator: Site Reference ID/Investigator# 92313, MD
Contact:
Email not avaialable

Houston, Texas
Facility: Site Reference ID/Investigator# 94339
Investigator: Site Reference ID/Investigator# 94339, MD
Contact:
Email not avaialable

Salt Lake City, Utah
Facility: Site Reference ID/Investigator# 131769
Investigator: Site Reference ID/Investigator# 131769, MD
Contact:
Email not avaialable




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