Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT01657799 : A Clinical Study Conducted in Multiple Centers Comparing Veliparib and Whole Brain Radiation Therapy (WBRT) Versus Placebo and WBRT in Subjects With Brain Metastases From Non Small Cell Lung Cancer (NSCLC)
PhasePhase 2
AgesMin: 18 Years Max: N/A
Eligibility
Inclusion Criteria:

- Subject must be greater than or equal to 18 years of age

- Subject must have cytologically or histologically confirmed non-small cell lung
cancer

- Subject must have brain metastases demonstrated on a MRI brain scan

- Subject must be eligible for WBRT

Exclusion Criteria:

- Subject is diagnosed with brain metastases greater than 28 days prior to treatment

- Subject received any prior form of cranial radiation and/or neurosurgery for their
brain metastases

- Subject's last dose of anti-cancer therapy or investigational therapy was less than
or equal to 7 days prior to treatment

- Subject has a Karnofsky Performance Score of less than 70

- Subject has significant dyspnea requiring supplemental oxygen therapy

- Subject has liver metastases (restaging is not required for known liver metastases)

- Subject has more than 2 sites (organ systems) of metastases from non-small cell lung
cancer with the exception of intra-cranial sites of metastases from non-small cell
lung cancer, thoracic sites of metastases from non-small cell lung cancer and bone
metastases

- Subject has leptomeningeal metastases or subarachnoid spread of tumor

- Subject has unresolved or unstable, serious toxicity from prior administration of
another investigational drug and/or prior anti-cancer treatment

- Subject has a known seizure disorder that is uncontrolled, or has seizures occurring
greater than or equal to 3 times a week over the past month. Subjects presenting with
symptoms of seizures from the brain metastases are eligible; however he/she should
receive adequate anti-seizure medication prior to study treatment

- Subject is pregnant or lactating

- Subject has previously been treated with a poly-(ADP-ribose)-polymerase inhibitor as
an investigational agent

- Subject has clinically significant and uncontrolled major medical condition(s)

- Subject has a history of another active cancer within the past 5 years except:
cervical cancer in situ, in situ carcinoma of the bladder, basal or squamous cell
carcinoma of the skin or other cancer in situ that is considered cured
LinksPermanent Link to THIS page: http://virtualtrials.com/nct/display1trial.cfm?nct=NCT01657799      |      Link to official Clinicaltrials.gov listing
Locations
Buenos Aires,
Argentina

Facility: Site Reference ID/Investigator# 68564
Investigator: Site Reference ID/Investigator# 68564
Contact:
Email not avaialable

Rosario, Santa Fe,
Argentina

Facility: Site Reference ID/Investigator# 68563
Investigator: Site Reference ID/Investigator# 68563
Contact:
Email not avaialable

Santa Fe,
Argentina

Facility: Site Reference ID/Investigator# 68562
Investigator: Site Reference ID/Investigator# 68562
Contact:
Email not avaialable

Bedford Park,
Australia

Facility: Site Reference ID/Investigator# 68366
Investigator: Site Reference ID/Investigator# 68366
Contact:
Email not avaialable

Brisbane,
Australia

Facility: Site Reference ID/Investigator# 69022
Investigator: Site Reference ID/Investigator# 69022
Contact:
Email not avaialable

East Melbourne,
Australia

Facility: Site Reference ID/Investigator# 68367
Investigator: Site Reference ID/Investigator# 68367
Contact:
Email not avaialable

Geelong,
Australia

Facility: Site Reference ID/Investigator# 68362
Investigator: Site Reference ID/Investigator# 68362
Contact:
Email not avaialable

Herston,
Australia

Facility: Site Reference ID/Investigator# 68364
Investigator: Site Reference ID/Investigator# 68364
Contact:
Email not avaialable

Kogarah,
Australia

Facility: Site Reference ID/Investigator# 68368
Investigator: Site Reference ID/Investigator# 68368
Contact:
Email not avaialable

Brussels,
Belgium

Facility: Site Reference ID/Investigator# 69382
Investigator: Site Reference ID/Investigator# 69382
Contact:
Email not avaialable

Brussels,
Belgium

Facility: Site Reference ID/Investigator# 68227
Investigator: Site Reference ID/Investigator# 68227
Contact:
Email not avaialable

Charleroi,
Belgium

Facility: Site Reference ID/Investigator# 68226
Investigator: Site Reference ID/Investigator# 68226
Contact:
Email not avaialable

Edegem,
Belgium

Facility: Site Reference ID/Investigator# 69384
Investigator: Site Reference ID/Investigator# 69384
Contact:
Email not avaialable

Ghent,
Belgium

Facility: Site Reference ID/Investigator# 68229
Investigator: Site Reference ID/Investigator# 68229
Contact:
Email not avaialable

Wilrijk,
Belgium

Facility: Site Reference ID/Investigator# 69385
Investigator: Site Reference ID/Investigator# 69385
Contact:
Email not avaialable

Montreal,
Canada

Facility: Site Reference ID/Investigator# 68277
Investigator: Site Reference ID/Investigator# 68277
Contact:
Email not avaialable

Montreal,
Canada

Facility: Site Reference ID/Investigator# 68276
Investigator: Site Reference ID/Investigator# 68276
Contact:
Email not avaialable

Montreal,
Canada

Facility: Site Reference ID/Investigator# 68153
Investigator: Site Reference ID/Investigator# 68153
Contact:
Email not avaialable

Ottawa,
Canada

Facility: Site Reference ID/Investigator# 68258
Investigator: Site Reference ID/Investigator# 68258
Contact:
Email not avaialable

Quebec,
Canada

Facility: Site Reference ID/Investigator# 68251
Investigator: Site Reference ID/Investigator# 68251
Contact:
Email not avaialable

Toronto,
Canada

Facility: Site Reference ID/Investigator# 65835
Investigator: Site Reference ID/Investigator# 65835
Contact:
Email not avaialable

Toronto,
Canada

Facility: Site Reference ID/Investigator# 68154
Investigator: Site Reference ID/Investigator# 68154
Contact:
Email not avaialable

Antofagasta,
Chile

Facility: Site Reference ID/Investigator# 68572
Investigator: Site Reference ID/Investigator# 68572
Contact:
Email not avaialable

Renaca, Vina del Mar,
Chile

Facility: Site Reference ID/Investigator# 68570
Investigator: Site Reference ID/Investigator# 68570
Contact:
Email not avaialable

Santiago,
Chile

Facility: Site Reference ID/Investigator# 68569
Investigator: Site Reference ID/Investigator# 68569
Contact:
Email not avaialable

Temuco,
Chile

Facility: Site Reference ID/Investigator# 68573
Investigator: Site Reference ID/Investigator# 68573
Contact:
Email not avaialable

Nova Vas Pod Plesi,
Czech Republic

Facility: Site Reference ID/Investigator# 68624
Investigator: Site Reference ID/Investigator# 68624
Contact:
Email not avaialable

Olomouc,
Czech Republic

Facility: Site Reference ID/Investigator# 68625
Investigator: Site Reference ID/Investigator# 68625
Contact:
Email not avaialable

Prague 10,
Czech Republic

Facility: Site Reference ID/Investigator# 68630
Investigator: Site Reference ID/Investigator# 68630
Contact:
Email not avaialable

Prague 5,
Czech Republic

Facility: Site Reference ID/Investigator# 68631
Investigator: Site Reference ID/Investigator# 68631
Contact:
Email not avaialable

Usti nad Labem,
Czech Republic

Facility: Site Reference ID/Investigator# 68632
Investigator: Site Reference ID/Investigator# 68632
Contact:
Email not avaialable

Alexandria,
Egypt

Facility: Site Reference ID/Investigator# 68803
Investigator: Site Reference ID/Investigator# 68803
Contact:
Email not avaialable

Cairo,
Egypt

Facility: Site Reference ID/Investigator# 68802
Investigator: Site Reference ID/Investigator# 68802
Contact:
Email not avaialable

Cairo,
Egypt

Facility: Site Reference ID/Investigator# 70733
Investigator: Site Reference ID/Investigator# 70733
Contact:
Email not avaialable

Helsinki,
Finland

Facility: Site Reference ID/Investigator# 74653
Investigator: Site Reference ID/Investigator# 74653
Contact:
Email not avaialable

Vaasa,
Finland

Facility: Site Reference ID/Investigator# 75977
Investigator: Site Reference ID/Investigator# 75977
Contact:
Email not avaialable

Dijon,
France

Facility: Site Reference ID/Investigator# 95119
Investigator: Site Reference ID/Investigator# 95119
Contact:
Email not avaialable

Marseille,
France

Facility: Site Reference ID/Investigator# 95115
Investigator: Site Reference ID/Investigator# 95115
Contact:
Email not avaialable

Paris,
France

Facility: Site Reference ID/Investigator# 95118
Investigator: Site Reference ID/Investigator# 95118
Contact:
Email not avaialable

Pierre-Benite,
France

Facility: Site Reference ID/Investigator# 95116
Investigator: Site Reference ID/Investigator# 95116
Contact:
Email not avaialable

Strasbourg,
France

Facility: Site Reference ID/Investigator# 95120
Investigator: Site Reference ID/Investigator# 95120
Contact:
Email not avaialable

Toulouse,
France

Facility: Site Reference ID/Investigator# 103775
Investigator: Site Reference ID/Investigator# 103775
Contact:
Email not avaialable

Budapest,
Hungary

Facility: Site Reference ID/Investigator# 118656
Investigator: Site Reference ID/Investigator# 118656
Contact:
Email not avaialable

Gyula,
Hungary

Facility: Site Reference ID/Investigator# 118676
Investigator: Site Reference ID/Investigator# 118676
Contact:
Email not avaialable

Matrahaza,
Hungary

Facility: Site Reference ID/Investigator# 118658
Investigator: Site Reference ID/Investigator# 118658
Contact:
Email not avaialable

Basan,
Korea, Republic of

Facility: Site Reference ID/Investigator# 77295
Investigator: Site Reference ID/Investigator# 77295
Contact:
Email not avaialable

Chungju-si,
Korea, Republic of

Facility: Site Reference ID/Investigator# 68225
Investigator: Site Reference ID/Investigator# 68225
Contact:
Email not avaialable

Gyeonggi-do,
Korea, Republic of

Facility: Site Reference ID/Investigator# 68224
Investigator: Site Reference ID/Investigator# 68224
Contact:
Email not avaialable

Incheon,
Korea, Republic of

Facility: Site Reference ID/Investigator# 77294
Investigator: Site Reference ID/Investigator# 77294
Contact:
Email not avaialable

Seoul,
Korea, Republic of

Facility: Site Reference ID/Investigator# 68223
Investigator: Site Reference ID/Investigator# 68223
Contact:
Email not avaialable

Seoul,
Korea, Republic of

Facility: Site Reference ID/Investigator# 68222
Investigator: Site Reference ID/Investigator# 68222
Contact:
Email not avaialable

Kristiansand,
Norway

Facility: Site Reference ID/Investigator# 75119
Investigator: Site Reference ID/Investigator# 75119
Contact:
Email not avaialable

Oslo,
Norway

Facility: Site Reference ID/Investigator# 68633
Investigator: Site Reference ID/Investigator# 68633
Contact:
Email not avaialable

Ekaterinburg,
Russian Federation

Facility: Site Reference ID/Investigator# 68667
Investigator: Site Reference ID/Investigator# 68667
Contact:
Email not avaialable

Irkutsk,
Russian Federation

Facility: Site Reference ID/Investigator# 107496
Investigator: Site Reference ID/Investigator# 107496
Contact:
Email not avaialable

Izhevsk,
Russian Federation

Facility: Site Reference ID/Investigator# 112295
Investigator: Site Reference ID/Investigator# 112295
Contact:
Email not avaialable

Moscow,
Russian Federation

Facility: Site Reference ID/Investigator# 68662
Investigator: Site Reference ID/Investigator# 68662
Contact:
Email not avaialable

Moscow,
Russian Federation

Facility: Site Reference ID/Investigator# 68666
Investigator: Site Reference ID/Investigator# 68666
Contact:
Email not avaialable

Moscow,
Russian Federation

Facility: Site Reference ID/Investigator# 71273
Investigator: Site Reference ID/Investigator# 71273
Contact:
Email not avaialable

Murmansk,
Russian Federation

Facility: Site Reference ID/Investigator# 94555
Investigator: Site Reference ID/Investigator# 94555
Contact:
Email not avaialable

Pyatigorsk,
Russian Federation

Facility: Site Reference ID/Investigator# 95257
Investigator: Site Reference ID/Investigator# 95257
Contact:
Email not avaialable

Saint Petersburg,
Russian Federation

Facility: Site Reference ID/Investigator# 95256
Investigator: Site Reference ID/Investigator# 95256
Contact:
Email not avaialable

Tula,
Russian Federation

Facility: Site Reference ID/Investigator# 68669
Investigator: Site Reference ID/Investigator# 68669
Contact:
Email not avaialable

Ulyanovsk,
Russian Federation

Facility: Site Reference ID/Investigator# 82793
Investigator: Site Reference ID/Investigator# 82793
Contact:
Email not avaialable

Barcelona,
Spain

Facility: Site Reference ID/Investigator# 80815
Investigator: Site Reference ID/Investigator# 80815
Contact:
Email not avaialable

Barcelona,
Spain

Facility: Site Reference ID/Investigator# 80818
Investigator: Site Reference ID/Investigator# 80818
Contact:
Email not avaialable

Madrid,
Spain

Facility: Site Reference ID/Investigator# 80814
Investigator: Site Reference ID/Investigator# 80814
Contact:
Email not avaialable

Madrid,
Spain

Facility: Site Reference ID/Investigator# 80817
Investigator: Site Reference ID/Investigator# 80817
Contact:
Email not avaialable

Majadahonda (Madrid),
Spain

Facility: Site Reference ID/Investigator# 82733
Investigator: Site Reference ID/Investigator# 82733
Contact:
Email not avaialable

Malaga,
Spain

Facility: Site Reference ID/Investigator# 80816
Investigator: Site Reference ID/Investigator# 80816
Contact:
Email not avaialable

Taichung,
Taiwan

Facility: Site Reference ID/Investigator# 80835
Investigator: Site Reference ID/Investigator# 80835
Contact:
Email not avaialable

Taichung City,
Taiwan

Facility: Site Reference ID/Investigator# 77873
Investigator: Site Reference ID/Investigator# 77873
Contact:
Email not avaialable

Tainan,
Taiwan

Facility: Site Reference ID/Investigator# 77874
Investigator: Site Reference ID/Investigator# 77874
Contact:
Email not avaialable

Taipei,
Taiwan

Facility: Site Reference ID/Investigator# 80833
Investigator: Site Reference ID/Investigator# 80833
Contact:
Email not avaialable

Taipei,
Taiwan

Facility: Site Reference ID/Investigator# 77875
Investigator: Site Reference ID/Investigator# 77875
Contact:
Email not avaialable

Taipei,
Taiwan

Facility: Site Reference ID/Investigator# 80834
Investigator: Site Reference ID/Investigator# 80834
Contact:
Email not avaialable

Chernivtsi,
Ukraine

Facility: Site Reference ID/Investigator# 81575
Investigator: Site Reference ID/Investigator# 81575
Contact:
Email not avaialable

Donetsk,
Ukraine

Facility: Site Reference ID/Investigator# 81573
Investigator: Site Reference ID/Investigator# 81573
Contact:
Email not avaialable

Kharkiv,
Ukraine

Facility: Site Reference ID/Investigator# 82754
Investigator: Site Reference ID/Investigator# 82754
Contact:
Email not avaialable

Sumy,
Ukraine

Facility: Site Reference ID/Investigator# 81574
Investigator: Site Reference ID/Investigator# 81574
Contact:
Email not avaialable

Ternopil,
Ukraine

Facility: Site Reference ID/Investigator# 82774
Investigator: Site Reference ID/Investigator# 82774
Contact:
Email not avaialable

Birmingham, Alabama
Facility: Site Reference ID/Investigator# 68495
Investigator: Site Reference ID/Investigator# 68495
Contact:
Email not avaialable

Chandler, Arizona
Facility: Site Reference ID/Investigator# 65828
Investigator: Site Reference ID/Investigator# 65828
Contact:
Email not avaialable

Tucson, Arizona
Facility: Site Reference ID/Investigator# 92623
Investigator: Site Reference ID/Investigator# 92623
Contact:
Email not avaialable

Tucson, Arizona
Facility: Site Reference ID/Investigator# 92618
Investigator: Site Reference ID/Investigator# 92618
Contact:
Email not avaialable

Tucson, Arizona
Facility: Site Reference ID/Investigator# 66052
Investigator: Site Reference ID/Investigator# 66052
Contact:
Email not avaialable

Little Rock, Arkansas
Facility: Site Reference ID/Investigator# 69287
Investigator: Site Reference ID/Investigator# 69287
Contact:
Email not avaialable

San Francisco, California
Facility: Site Reference ID/Investigator# 72793
Investigator: Site Reference ID/Investigator# 72793
Contact:
Email not avaialable

Lone Tree, Colorado
Facility: Site Reference ID/Investigator# 92616
Investigator: Site Reference ID/Investigator# 92616
Contact:
Email not avaialable

Deerfield Beach, Florida
Facility: Site Reference ID/Investigator# 68161
Investigator: Site Reference ID/Investigator# 68161
Contact:
Email not avaialable

Atlanta, Georgia
Facility: Site Reference ID/Investigator# 65824
Investigator: Site Reference ID/Investigator# 65824
Contact:
Email not avaialable

Chicago, Illinois
Facility: Site Reference ID/Investigator# 66025
Investigator: Site Reference ID/Investigator# 66025
Contact:
Email not avaialable

Goshen, Indiana
Facility: Site Reference ID/Investigator# 68494
Investigator: Site Reference ID/Investigator# 68494
Contact:
Email not avaialable

Kansas City, Kansas
Facility: Site Reference ID/Investigator# 68319
Investigator: Site Reference ID/Investigator# 68319
Contact:
Email not avaialable

Baltimore, Maryland
Facility: Site Reference ID/Investigator# 65831
Investigator: Site Reference ID/Investigator# 65831
Contact:
Email not avaialable

Detroit, Michigan
Facility: Site Reference ID/Investigator# 65830
Investigator: Site Reference ID/Investigator# 65830
Contact:
Email not avaialable

Farmington Hills, Michigan
Facility: Site Reference ID/Investigator# 68311
Investigator: Site Reference ID/Investigator# 68311
Contact:
Email not avaialable

Lansing, Michigan
Facility: Site Reference ID/Investigator# 84773
Investigator: Site Reference ID/Investigator# 84773
Contact:
Email not avaialable

Bronx, New York
Facility: Site Reference ID/Investigator# 118015
Investigator: Site Reference ID/Investigator# 118015
Contact:
Email not avaialable

Manhasset, New York
Facility: Site Reference ID/Investigator# 68317
Investigator: Site Reference ID/Investigator# 68317
Contact:
Email not avaialable

New York, New York
Facility: Site Reference ID/Investigator# 66047
Investigator: Site Reference ID/Investigator# 66047
Contact:
Email not avaialable

Cleveland, Ohio
Facility: Site Reference ID/Investigator# 66028
Investigator: Site Reference ID/Investigator# 66028
Contact:
Email not avaialable

Cleveland, Ohio
Facility: Site Reference ID/Investigator# 85054
Investigator: Site Reference ID/Investigator# 85054
Contact:
Email not avaialable

Philadelphia, Pennsylvania
Facility: Site Reference ID/Investigator# 70553
Investigator: Site Reference ID/Investigator# 70553
Contact:
Email not avaialable

Philadelphia, Pennsylvania
Facility: Site Reference ID/Investigator# 65829
Investigator: Site Reference ID/Investigator# 65829
Contact:
Email not avaialable

Providence, Rhode Island
Facility: Site Reference ID/Investigator# 85373
Investigator: Site Reference ID/Investigator# 85373
Contact:
Email not avaialable

Arlington, Texas
Facility: Site Reference ID/Investigator# 92614
Investigator: Site Reference ID/Investigator# 92614
Contact:
Email not avaialable

Dallas, Texas
Facility: Site Reference ID/Investigator# 66703
Investigator: Site Reference ID/Investigator# 66703
Contact:
Email not avaialable

Denton, Texas
Facility: Site Reference ID/Investigator# 92615
Investigator: Site Reference ID/Investigator# 92615
Contact:
Email not avaialable




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