Clinical Trial Details
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[Information provided by:, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT01587144 : Safety and Efficacy Study of Lucanthone When Used in Combination With Temozolomide(TMZ) and Radiation to Treat Glioblastoma Multiforme(GBM)
PhasePhase 2
AgesMin: 18 Years Max: 70 Years
Main Inclusion Criteria:

1. 18 and 70 years of age

2. Histologically proven GBM who

- May or may not have undergone surgery

- Has at least one well demarcated bidimensional measurable lesion; and

- Is scheduled to receive treatment with temozolomide and radiation.

3. Karnofsky score ? 70%.

Main Exclusion Criteria:

1. Diagnosis of recurrent brain tumor.

2. Received temozolomide previously.

3. Absolute neutrophil count ? 1.5 X 109/L.

4. Screening platelet count < 100 K/uL.

5. Screening bilirubin > 1.6 mg/dL.

6. Screening creatinine > 2.25 mg/dL in men and 1.8 mg/dL in women.

7. Screening ALT or AST > 2.5 times the upper limit of the laboratory reference range.

8. Unstable medical condition or significant comorbid pathophysiology (e.g. active
infection, poorly controlled diabetes, unstable angina, severe heart failure) that
would interfere with his/her participation in the study.

9. Enrolled, or plans to enroll, in a concurrent treatment protocol with another
investigational product.

10. Receiving, or plans to receive, an anti-cancer therapy other than temozolomide during
the study.

11. Received prior chemotherapy or radiation therapy within four weeks of enrollment.
LinksPermanent Link to THIS page:      |      Link to official listing
Ahmedabad, Gujarat

Facility: Gujarat Cancer Research Institute
Investigator: Dr. Rakeshkumar Vyas
Email not avaialable

Mumbai, Maharashtra

Facility: Jaslok Hospital & Research Centre
Investigator: Dr. Suresh H Advani
Email not avaialable

Jaipur, Rajasthan

Facility: Bhagwan Mahaveer Cancer Hospital & Reseach Centre
Investigator: Dr. Naresh Somani
Email not avaialable

Kolkata, West Bengal

Facility: Chittaranjan National Cencer Institute
Investigator: Dr. Jaydip Biswas
Email not avaialable

Orange, California
Facility: UCI Medical Center
Investigator: Jose Carrillo, MD
Contact: Christina Siwak Phone: 714-456-8549
Email not avaialable

Amherst, New York
Facility: Dent Neurologic Institute
Investigator: Lazlo Mechtler, MD
Contact: Olga Ananina Phone: 716-558-5670
Click HERE to send email to this center

Cleveland, Ohio
Facility: Cleveland Clinic
Investigator: Manmeet Ahluwalia, MD
Contact: Renata McBride Phone: 216-312-5170
Click HERE to send email to this center

Cleveland, Ohio
Facility: Fairview Hospital Moll Cancer Center/Cleveland Clinic
Investigator: Manmeet Ahluwalia, MD
Contact: Patti O'Reilly, RN Phone: 216-476-9362
Email not avaialable

Mayfield, Ohio
Facility: Hillcrest Hospital Hirsh Cancer Center/Cleveland Clinic
Investigator: Manmeet Ahluwalia, MD
Contact: Noelle Clark, RN Phone: 440-312-9046
Email not avaialable

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