Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT01217437 : Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors
PhasePhase 2
AgesMin: N/A Max: 21 Years
Eligibility
Inclusion Criteria:

- Medulloblastoma or PNET of childhood that has relapsed or become refractory to
standard chemotherapy; patients with pineoblastoma are eligible

- Patients must have had histologic verification of the malignancy at original
diagnosis or at the time of recurrence

- Patients must have clear residual disease, defined as tumor that is measurable in two
perpendicular diameters on magnetic resonance imaging (MRI) OR diffuse leptomeningeal
disease OR clear MRI evidence of disease that may not be measurable in two
perpendicular diameters

- All patients must have a brain MRI with and without gadolinium and a spine MRI with
gadolinium performed within 2 weeks prior to study enrollment

- Patients must have a Lansky or Karnofsky performance status score of >= 50%,
corresponding to Eastern Cooperative Oncology Group (ECOG) categories of 0, 1, or 2
(use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of
age)

- Patients must have a life expectancy of >= 8 weeks

- Patients must have experienced at least one and at most two relapses prior to study
enrollment; patients with primary refractory disease are eligible

- Patients must have fully recovered from the acute toxic effects of all prior
chemotherapy, immunotherapy, or radiotherapy prior to entering this study

- Myelosuppressive chemotherapy: Must not have received within 3 weeks of entry
onto this study (6 weeks if prior nitrosourea)

- Biologic (anti-neoplastic agent): At least 7 days since the completion of
therapy with a biologic agent; at least 3 weeks for biologic agents with a long
half life, such as antibodies

- External beam radiation therapy (XRT): Must not have received craniospinal
radiotherapy within 24 weeks prior to study entry; the tumor designated as
"measurable" for protocol purposes must not have received radiation within 12
weeks prior to study entry); focal radiation to areas of symptomatic metastatic
disease must not be given within 14 days of study entry

- Stem cell transplant (SCT): For autologous SCT, >= 3 months must have elapsed
prior to study entry

- Study specific limitations on prior therapy:

- Patients must not have previously received bevacizumab, irinotecan,
temozolomide or other anti-vascular endothelial growth factor (VEGF)
inhibitor

- Patients must not be taking enzyme-inducing antiepileptic medicines within
1 week of study entry

- Patients must have recovered from any surgical procedure before enrolling on this
study:

- Patients with a major surgical procedure within 28 days prior to enrollment
should be excluded

- Patients with an intermediate surgical procedure within 14 days prior to
enrollment should be excluded

- For minor surgical procedures (including Broviac line or infusaport placement),
patients should not receive the first planned dose of bevacizumab until the
wound is healed and at least 7 days have elapsed

- There should be no anticipation of need for major surgical procedures during the
course of the study

- Examples of major, intermediate, or minor surgical procedures:

- Major procedures: Major craniotomy for tumor resection; organ
resection; bowel wall anastomosis; arteriovenous grafts; exploratory
laparotomy; thoracotomy

- Intermediate procedures: Ventriculoperitoneal (VP)-shunt placement;
stereotactic brain biopsy

- Minor procedures: Incision and drainage of superficial skin abscesses;
punch biopsy of skin lesions; superficial skin wound suturing; bone
marrow aspirate and/or biopsy; fine needle aspirations; Broviac line
or infusaport placement; paracentesis or thoracocentesis

- Please note: Lumbar punctures or placement of peripherally inserted central
catheter (PICC) lines are not considered minor procedures and may occur at any
time prior to or during therapy

- Hypertension must be well controlled (=< 95th percentile for age and height if
patient is =< 17 years) on stable doses of medication

- Concomitant medications restrictions:

- Growth factor(s): Must not have received within 7 days of entry onto this study

- Steroids: Patients who are receiving corticosteroids must be on a stable or
decreasing dose for at least 7 days

- Study Specific: Patients must not be currently taking nonsteroidal
anti-inflammatory drugs (NSAIDs), clopidrogel, dipyridamole or aspirin therapy >
81 mg/day

- Peripheral absolute neutrophil count (ANC) >= 1000/uL (must not have received
filgrastim [G-CSF] within the prior 7 days)

- Platelet count >= 100,000/uL (transfusion independent)

- Hemoglobin >= 8.0 gm/dL (may receive packed red blood cell [PRBC] transfusions)

- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min OR
a serum creatinine based on age/gender as follows:

- =< 0.4 mg/dL (for patients aged 1 month to < 6 months)

- =< 0.5 mg/dL (for patients aged 6 months to < 1 year)

- =< 0.6 mg/dL (for patients aged 1 to < 2 years)

- =< 0.8 mg/dL (for patients aged 2 to < 6 years)

- =< 1 mg/dL (for patients aged 6 to < 10 years)

- =< 1.2 mg/dL (for patients aged 10 to < 13 years)

- =< 1.4 mg/dL (for female patients aged >= 13 years)

- =< 1.5 mg/dL (for male patients aged 13 to < 16 years)

- =< 1.7 mg/dL (for male patients aged >= 16 years)

- Urine protein should be screened by dipstick analysis; if protein >= 2+ on dipstick,
then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio > 0.5,
24-hour urine protein should be obtained and the level should be < 1000 mg/24 hours
for patient enrollment

- Total bilirubin =< 1.5 x upper limit of normal (ULN) for age

- Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 3 x
upper limit of normal (ULN) for age

- Central nervous system function defined as

- Patients with a seizure disorder may be enrolled if well-controlled and on
non-enzyme inducing anticonvulsants

- Adequate coagulation defined as

- International normalized ratio (INR)/prothrombin time (PT) =< 1.5 x upper limit
of normal

Exclusion Criteria:

- Patients with a serious or non-healing wound, ulcer, or bone fracture are not
eligible for this study

- Patients must not have a history of abdominal fistula, gastrointestinal perforation
or intra-abdominal abscess within 6 months prior to study entry

- Patients must not have a known bleeding diathesis or coagulopathy

- Patients must not have had significant vascular disease (eg, aortic aneurysm
requiring surgical repair, deep venous or arterial thrombosis) within the last 6
months prior to study entry

- Patients must not have a known thrombophilic condition (i.e. protein S, protein C or
antithrombin III deficiency, Factor V Leiden, Factor II G20210A mutation,
homocysteinemia or antiphospholipid antibody syndrome); testing is not required in
patients without thrombophilic history

- Patients must not have evidence of new CNS hemorrhage on baseline MRI obtained within
14 days prior to study enrollment

- Patients with a history of stroke, myocardial infarction, transient ischemic attack
(TIA), severe or unstable angina, peripheral vascular disease, or grade II or greater
congestive heart failure within the past 6 months are not eligible

- Patients must not have serious and inadequately controlled cardiac arrhythmia

- Female patients who are pregnant are not eligible for this study

- Female patients who are breastfeeding are not eligible for this study unless they
agree not to breastfeed

- Female patients of childbearing potential must have a negative pregnancy test

- Sexually active patients of childbearing potential must agree to use an effective
method of contraception during the study and for at least 6 months after the
completion of bevacizumab therapy

- Patients with known hypersensitivity to Chinese hamster ovary cell products or other
recombinant human antibodies
LinksPermanent Link to THIS page: http://virtualtrials.com/nct/display1trial.cfm?nct=NCT01217437      |      Link to official Clinicaltrials.gov listing
Locations
Hunter Regional Mail Centre, New South Wales
Australia

Facility: John Hunter Children's Hospital
Investigator: Elizabeth L. Hesketh
Contact: Elizabeth L. Hesketh Phone: 888-823-5923
Click HERE to send email to this center

Randwick, New South Wales
Australia

Facility: Sydney Children's Hospital
Investigator: Draga Barbaric
Contact: Draga Barbaric Phone: (02) 9382-1721
Email not avaialable

Westmead, New South Wales
Australia

Facility: The Children's Hospital at Westmead
Investigator: Geoffrey B. McCowage
Contact: Geoffrey B. McCowage Phone: 61-2-9845 1400
Email not avaialable

Herston, Queensland
Australia

Facility: Royal Brisbane and Women's Hospital
Investigator: Timothy E. Hassall
Contact: Timothy E. Hassall Phone: 888-823-5923
Click HERE to send email to this center

South Brisbane, Queensland
Australia

Facility: Lady Cilento Children's Hospital
Investigator: Helen Irving
Contact: Helen Irving Phone: 888-823-5923
Click HERE to send email to this center

Perth, Western Australia
Australia

Facility: Princess Margaret Hospital for Children
Investigator: Catherine H. Cole
Contact: Catherine H. Cole Phone: (08) 9340 8222
Click HERE to send email to this center

Quebec,
Canada

Facility: Centre Hospitalier Universitaire de Quebec
Investigator: Bruno Michon
Contact: Bruno Michon Phone: 418-525-4444
Email not avaialable

Calgary, Alberta
Canada

Facility: Alberta Children's Hospital
Investigator: Douglas R. Strother
Contact: Douglas R. Strother Phone: 403-220-6898
Click HERE to send email to this center

Vancouver, British Columbia
Canada

Facility: British Columbia Children's Hospital
Investigator: Caron Strahlendorf
Contact: Caron Strahlendorf Phone: 604-875-2345
Email not avaialable

Winnipeg, Manitoba
Canada

Facility: CancerCare Manitoba
Investigator: Rochelle A. Yanofsky
Contact: Rochelle A. Yanofsky Phone: 866-561-1026
Click HERE to send email to this center

Halifax, Nova Scotia
Canada

Facility: IWK Health Centre
Investigator: Conrad V. Fernandez
Contact: Conrad V. Fernandez Phone: 902-470-8394
Email not avaialable

Hamilton, Ontario
Canada

Facility: McMaster Children's Hospital at Hamilton Health Sciences
Investigator: Carol Portwine
Contact: Carol Portwine Phone: 905-521-2100
Email not avaialable

Kingston, Ontario
Canada

Facility: Cancer Centre of Southeastern Ontario at Kingston General Hospital
Investigator: Mariana P. Silva
Contact: Mariana P. Silva Phone: 613-544-2630
Email not avaialable

Ottawa, Ontario
Canada

Facility: Children's Hospital of Eastern Ontario
Investigator: Jacqueline M. Halton
Contact: Jacqueline M. Halton Phone: 613-738-3931
Email not avaialable

Toronto, Ontario
Canada

Facility: Hospital for Sick Children
Investigator: Sarah W. Alexander
Contact: Sarah W. Alexander Phone: 416-813-7654
Click HERE to send email to this center

Montreal, Quebec
Canada

Facility: Centre Hospitalier Universitaire Sainte-Justine
Investigator: Yvan Samson
Contact: Yvan Samson Phone: 514-345-4931
Email not avaialable

Montreal, Quebec
Canada

Facility: The Montreal Children's Hospital of the MUHC
Investigator: Sharon B. Abish
Contact: Sharon B. Abish Phone: 514-412-4445
Click HERE to send email to this center

Saskatoon, Saskatchewan
Canada

Facility: Saskatoon Cancer Centre
Investigator: Christopher Mpofu
Contact: Christopher Mpofu Phone: 306-655-2914
Email not avaialable

Christchurch,
New Zealand

Facility: Christchurch Hospital
Investigator: Siobhan F. Cross
Contact: Siobhan F. Cross Phone: 03 364 0640
Email not avaialable

Grafton, Auckland
New Zealand

Facility: Starship Children's Hospital
Investigator: Mark A. Winstanley
Contact: Mark A. Winstanley Phone: 0800 728 436
Email not avaialable

San Juan,
Puerto Rico

Facility: University Pediatric Hospital
Investigator: Luis A. Clavell
Contact: Luis A. Clavell Phone: 787-765-2363
Email not avaialable

Birmingham, Alabama
Facility: Children's Hospital of Alabama
Investigator: Alyssa T. Reddy
Contact: Alyssa T. Reddy Phone: 888-823-5923
Click HERE to send email to this center

Phoenix, Arizona
Facility: Phoenix Childrens Hospital
Investigator: Jessica Boklan
Contact: Jessica Boklan Phone: 602-546-0920
Email not avaialable

Little Rock, Arkansas
Facility: Arkansas Children's Hospital
Investigator: David L. Becton
Contact: David L. Becton Phone: 501-364-7373
Email not avaialable

Downey, California
Facility: Southern California Permanente Medical Group
Investigator: Robert M. Cooper
Contact: Robert M. Cooper Phone: 626-564-3455
Email not avaialable

Loma Linda, California
Facility: Loma Linda University Medical Center
Investigator: Albert Kheradpour
Contact: Albert Kheradpour Phone: 909-558-3375
Email not avaialable

Long Beach, California
Facility: Miller Children's and Women's Hospital Long Beach
Investigator: Cecilia H. Fu
Contact: Cecilia H. Fu Phone: 562-933-5600
Email not avaialable

Los Angeles, California
Facility: Children's Hospital Los Angeles
Investigator: Leo Mascarenhas
Contact: Leo Mascarenhas Phone: 323-361-4110
Email not avaialable

Madera, California
Facility: Children's Hospital Central California
Investigator: Vonda L. Crouse
Contact: Vonda L. Crouse Phone: 866-353-5437
Email not avaialable

Oakland, California
Facility: Kaiser Permanente-Oakland
Investigator: Steven K. Bergstrom
Contact: Steven K. Bergstrom Phone: 626-564-3455
Email not avaialable

Orange, California
Facility: Children's Hospital of Orange County
Investigator: Violet Shen
Contact: Violet Shen Phone: 714-997-3000
Email not avaialable

Palo Alto, California
Facility: Lucile Packard Children's Hospital Stanford University
Investigator: Neyssa M. Marina
Contact: Neyssa M. Marina Phone: 650-498-7061
Click HERE to send email to this center

Sacramento, California
Facility: Sutter General Hospital
Investigator: Yung S. Yim
Contact: Yung S. Yim Phone: 415-209-2686
Click HERE to send email to this center

Sacramento, California
Facility: University of California Davis Comprehensive Cancer Center
Investigator: Marcio H. Malogolowkin
Contact: Marcio H. Malogolowkin Phone: 916-734-3089
Email not avaialable

San Diego, California
Facility: Rady Children's Hospital - San Diego
Investigator: William D. Roberts
Contact: William D. Roberts Phone: 858-966-5934
Email not avaialable

San Francisco, California
Facility: UCSF Medical Center-Mission Bay
Investigator: Anuradha Banerjee
Contact: Anuradha Banerjee Phone: 877-827-3222
Email not avaialable

Hartford, Connecticut
Facility: Connecticut Children's Medical Center
Investigator: Michael S. Isakoff
Contact: Michael S. Isakoff Phone: 860-545-9981
Email not avaialable

Wilmington, Delaware
Facility: Alfred I duPont Hospital for Children
Investigator: Andrew W. Walter
Contact: Andrew W. Walter Phone: 302-651-5755
Email not avaialable

Washington, District of Columbia
Facility: Children's National Medical Center
Investigator: Jeffrey S. Dome
Contact: Jeffrey S. Dome Phone: 202-884-2549
Email not avaialable

Fort Myers, Florida
Facility: Golisano Children's Hospital of Southwest Florida
Investigator: Emad K. Salman
Contact: Emad K. Salman Phone: 239-343-5333
Email not avaialable

Jacksonville, Florida
Facility: Nemours Children's Clinic-Jacksonville
Investigator: Andrew W. Walter
Contact: Andrew W. Walter Phone: 302-651-5755
Email not avaialable

Orlando, Florida
Facility: Florida Hospital Orlando
Investigator: Fouad M. Hajjar
Contact: Fouad M. Hajjar Phone: 407-303-5623
Email not avaialable

Orlando, Florida
Facility: Nemours Children's Hospital
Investigator: Andrew W. Walter
Contact: Andrew W. Walter Phone: 302-651-5755
Email not avaialable

Pensacola, Florida
Facility: Nemours Children's Clinic - Pensacola
Investigator: Andrew W. Walter
Contact: Andrew W. Walter Phone: 302-651-5755
Email not avaialable

Saint Petersburg, Florida
Facility: All Children's Hospital
Investigator: Gregory A. Hale
Contact: Gregory A. Hale Phone: 727-767-2423
Click HERE to send email to this center

Tampa, Florida
Facility: Saint Joseph's Hospital/Children's Hospital-Tampa
Investigator: Erin M. Cockrell
Contact: Erin M. Cockrell Phone: 800-882-4123
Email not avaialable

West Palm Beach, Florida
Facility: Saint Mary's Hospital
Investigator: Narayana Gowda
Contact: Narayana Gowda Phone: 888-823-5923
Click HERE to send email to this center

Atlanta, Georgia
Facility: Children's Healthcare of Atlanta - Egleston
Investigator: Glen Lew
Contact: Glen Lew Phone: 404-785-1112
Email not avaialable

Savannah, Georgia
Facility: Memorial University Medical Center
Investigator: J. M. Johnston
Contact: J. M. Johnston Phone: 912-350-8568
Email not avaialable

Honolulu, Hawaii
Facility: Kapiolani Medical Center for Women and Children
Investigator: Robert W. Wilkinson
Contact: Robert W. Wilkinson Phone: 808-983-6090
Email not avaialable

Boise, Idaho
Facility: Saint Luke's Mountain States Tumor Institute
Investigator: Eugenia Chang
Contact: Eugenia Chang Phone: 800-845-4624
Email not avaialable

Chicago, Illinois
Facility: Lurie Children's Hospital-Chicago
Investigator: Stewart Goldman
Contact: Stewart Goldman Phone: 773-880-4562
Email not avaialable

Chicago, Illinois
Facility: University of Chicago Comprehensive Cancer Center
Investigator: Susan L. Cohn
Contact: Susan L. Cohn Phone: 773-834-7424
Email not avaialable

Chicago, Illinois
Facility: University of Illinois
Investigator: Mary L. Schmidt
Contact: Mary L. Schmidt Phone: 312-355-3046
Email not avaialable

Oak Lawn, Illinois
Facility: Advocate Children's Hospital-Oak Lawn
Investigator: Rebecca E. McFall
Contact: Rebecca E. McFall Phone: 847-723-7570
Email not avaialable

Peoria, Illinois
Facility: Saint Jude Midwest Affiliate
Investigator: Karen S. Fernandez
Contact: Karen S. Fernandez Phone: 309-655-3258
Email not avaialable

Indianapolis, Indiana
Facility: Riley Hospital for Children
Investigator: Robert J. Fallon
Contact: Robert J. Fallon Phone: 888-823-5923
Click HERE to send email to this center

Des Moines, Iowa
Facility: Blank Children's Hospital
Investigator: Wendy L. Woods-Swafford
Contact: Wendy L. Woods-Swafford Phone: 515-241-6729
Email not avaialable

Lexington, Kentucky
Facility: University of Kentucky/Markey Cancer Center
Investigator: Lars M. Wagner
Contact: Lars M. Wagner Phone: 859-257-3379
Email not avaialable

Louisville, Kentucky
Facility: Kosair Children's Hospital
Investigator: Kenneth G. Lucas
Contact: Kenneth G. Lucas Phone: 866-530-5516
Email not avaialable

New Orleans, Louisiana
Facility: Children's Hospital New Orleans
Investigator: Lolie C. Yu
Contact: Lolie C. Yu Phone: 504-894-5377
Email not avaialable

Baltimore, Maryland
Facility: Johns Hopkins University/Sidney Kimmel Cancer Center
Investigator: Kenneth J. Cohen
Contact: Kenneth J. Cohen Phone: 410-955-8804
Click HERE to send email to this center

Bethesda, Maryland
Facility: Walter Reed National Military Medical Center
Investigator: Anne B. Warwick
Contact: Anne B. Warwick Phone: 301-319-2100
Email not avaialable

Detroit, Michigan
Facility: Wayne State University/Karmanos Cancer Institute
Investigator: Maxim Y. Yankelevich
Contact: Maxim Y. Yankelevich Phone: 313-576-9363
Email not avaialable

Kalamazoo, Michigan
Facility: Bronson Methodist Hospital
Investigator: Katharina E. Elliott
Contact: Katharina E. Elliott Phone: 800-227-2345
Email not avaialable

Minneapolis, Minnesota
Facility: Children's Hospitals and Clinics of Minnesota - Minneapolis
Investigator: Michael K. Richards
Contact: Michael K. Richards Phone: 612-813-5193
Email not avaialable

Minneapolis, Minnesota
Facility: University of Minnesota Medical Center-Fairview
Investigator: Christopher L. Moertel
Contact: Christopher L. Moertel Phone: 612-624-2620
Email not avaialable

Rochester, Minnesota
Facility: Mayo Clinic
Investigator: Amulya A. Nageswara Rao
Contact: Amulya A. Nageswara Rao Phone: 507-538-7623
Email not avaialable

Jackson, Mississippi
Facility: University of Mississippi Medical Center
Investigator: Gail C. Megason
Contact: Gail C. Megason Phone: 601-815-6700
Email not avaialable

Columbia, Missouri
Facility: Columbia Regional
Investigator: Thomas W. Loew
Contact: Thomas W. Loew Phone: 573-882-7440
Email not avaialable

Kansas City, Missouri
Facility: The Childrens Mercy Hospital
Investigator: Maxine L. Hetherington
Contact: Maxine L. Hetherington Phone: 816-234-3265
Email not avaialable

Saint Louis, Missouri
Facility: Cardinal Glennon Children's Medical Center
Investigator: William S. Ferguson
Contact: William S. Ferguson Phone: 314-268-4000
Email not avaialable

Saint Louis, Missouri
Facility: Mercy Hospital Saint Louis
Investigator: Bethany G. Sleckman
Contact: Bethany G. Sleckman Phone: 913-948-5588
Email not avaialable

Saint Louis, Missouri
Facility: Washington University School of Medicine
Investigator: Robert J. Hayashi
Contact: Robert J. Hayashi Phone: 800-600-3606
Click HERE to send email to this center

Las Vegas, Nevada
Facility: Children's Specialty Center of Nevada II
Investigator: Jonathan Bernstein
Contact: Jonathan Bernstein Phone: 702-384-0013
Email not avaialable

Las Vegas, Nevada
Facility: Nevada Cancer Research Foundation CCOP
Investigator: Nik Farahana N. Rashid
Contact: Nik Farahana N. Rashid Phone: 702-384-0013
Email not avaialable

Las Vegas, Nevada
Facility: Summerlin Hospital Medical Center
Investigator: Jonathan Bernstein
Contact: Jonathan Bernstein Phone: 702-384-0013
Email not avaialable

Las Vegas, Nevada
Facility: Sunrise Hospital and Medical Center
Investigator: Nik Farahana N. Rashid
Contact: Nik Farahana N. Rashid Phone: 702-384-0013
Email not avaialable

Las Vegas, Nevada
Facility: University Medical Center of Southern Nevada
Investigator: Jonathan Bernstein
Contact: Jonathan Bernstein Phone: 702-384-0013
Email not avaialable

Lebanon, New Hampshire
Facility: Dartmouth Hitchcock Medical Center
Investigator: Sara Chaffee
Contact: Sara Chaffee Phone: 800-639-6918
Click HERE to send email to this center

Morristown, New Jersey
Facility: Morristown Medical Center
Investigator: Steven L. Halpern
Contact: Steven L. Halpern Phone: 973-971-5900
Email not avaialable

New Brunswick, New Jersey
Facility: Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
Investigator: Richard A. Drachtman
Contact: Richard A. Drachtman Phone: 732-235-8675
Email not avaialable

New Brunswick, New Jersey
Facility: Saint Peter's University Hospital
Investigator: Stanley Calderwood
Contact: Stanley Calderwood Phone: 732-745-8600
Click HERE to send email to this center

Summit, New Jersey
Facility: Overlook Hospital
Investigator: Steven L. Halpern
Contact: Steven L. Halpern Phone: 973-971-5900
Email not avaialable

Albuquerque, New Mexico
Facility: University of New Mexico Cancer Center
Investigator: Adam S. Levy
Contact: Adam S. Levy Phone: 718-741-2342
Click HERE to send email to this center

Albuquerque, New Mexico
Facility: University of New Mexico Cancer Center
Investigator: Koh B. Boayue
Contact: Koh B. Boayue Phone: 505-272-6972
Email not avaialable

Albany, New York
Facility: Albany Medical Center
Investigator: Vikramjit S. Kanwar
Contact: Vikramjit S. Kanwar Phone: 518-262-3368
Email not avaialable

Bronx, New York
Facility: Montefiore Medical Center - Moses Campus
Investigator: Peter D. Cole
Contact: Peter D. Cole Phone: 718-904-2730
Click HERE to send email to this center

Buffalo, New York
Facility: Roswell Park Cancer Institute
Investigator: Martin L. Brecher
Contact: Martin L. Brecher Phone: 877-275-7724
Email not avaialable

New Hyde Park, New York
Facility: The Steven and Alexandra Cohen Children's Medical Center of New York
Investigator: Mark P. Atlas
Contact: Mark P. Atlas Phone: 718-470-3470
Email not avaialable

New York, New York
Facility: Columbia University Medical Center
Investigator: Alice Lee
Contact: Alice Lee Phone: 212-305-8615
Email not avaialable

New York, New York
Facility: Laura and Issac Perlmutter Cancer Center at NYU Langone
Investigator: Jeffrey C. Allen
Contact: Jeffrey C. Allen Phone: 212-263-4434
Click HERE to send email to this center

New York, New York
Facility: Memorial Sloan-Kettering Cancer Center
Investigator: Peter G. Steinherz
Contact: Peter G. Steinherz Phone: 212-639-7202
Email not avaialable

Rochester, New York
Facility: University of Rochester
Investigator: Jeffrey R. Andolina
Contact: Jeffrey R. Andolina Phone: 585-275-5830
Email not avaialable

Syracuse, New York
Facility: State University of New York Upstate Medical University
Investigator: Karol H. Kerr
Contact: Karol H. Kerr Phone: 315-464-5476
Email not avaialable

Valhalla, New York
Facility: New York Medical College
Investigator: Jessica C. Hochberg
Contact: Jessica C. Hochberg Phone: 914-594-3794
Email not avaialable

Chapel Hill, North Carolina
Facility: University of North Carolina at Chapel Hill
Investigator: Stuart H. Gold
Contact: Stuart H. Gold Phone: 877-668-0683
Click HERE to send email to this center

Charlotte, North Carolina
Facility: Carolinas Medical Center/Levine Cancer Institute
Investigator: Joel A. Kaplan
Contact: Joel A. Kaplan Phone: 704-355-2884
Email not avaialable

Fargo, North Dakota
Facility: Sanford Medical Center-Fargo
Investigator: Samuel O. Anim
Contact: Samuel O. Anim Phone: 701-234-6161
Email not avaialable

Akron, Ohio
Facility: Children's Hospital Medical Center of Akron
Investigator: Steven J. Kuerbitz
Contact: Steven J. Kuerbitz Phone: 330-543-3193
Email not avaialable

Cincinnati, Ohio
Facility: Cincinnati Children's Hospital Medical Center
Investigator: John P. Perentesis
Contact: John P. Perentesis Phone: 513-636-2799
Email not avaialable

Cleveland, Ohio
Facility: Cleveland Clinic Foundation
Investigator: Aron Flagg
Contact: Aron Flagg Phone: 866-223-8100
Email not avaialable

Cleveland, Ohio
Facility: Rainbow Babies and Childrens Hospital
Investigator: Yousif (Joe) H. Matloub
Contact: Yousif (Joe) H. Matloub Phone: 216-844-5437
Email not avaialable

Columbus, Ohio
Facility: Nationwide Children's Hospital
Investigator: Mark A. Ranalli
Contact: Mark A. Ranalli Phone: 614-722-2708
Email not avaialable

Dayton, Ohio
Facility: Dayton Children's Hospital
Investigator: Ayman A. El-Sheikh
Contact: Ayman A. El-Sheikh Phone: 800-237-1225
Email not avaialable

Oklahoma City, Oklahoma
Facility: University of Oklahoma Health Sciences Center
Investigator: Rene Y. McNall-Knapp
Contact: Rene Y. McNall-Knapp Phone: 405-271-4272
Click HERE to send email to this center

Portland, Oregon
Facility: Legacy Emanuel Children's Hospital
Investigator: Janice F. Olson
Contact: Janice F. Olson Phone: 503-413-2560
Email not avaialable

Portland, Oregon
Facility: Legacy Emanuel Hospital and Health Center
Investigator: Janice F. Olson
Contact: Janice F. Olson Phone: 503-413-2560
Email not avaialable

Portland, Oregon
Facility: Oregon Health and Science University
Investigator: Kellie J. Nazemi
Contact: Kellie J. Nazemi Phone: 503-494-1080
Click HERE to send email to this center

Danville, Pennsylvania
Facility: Geisinger Medical Center
Investigator: Jagadeesh Ramdas
Contact: Jagadeesh Ramdas Phone: 570-271-5251
Email not avaialable

Hershey, Pennsylvania
Facility: Penn State Hershey Children's Hospital
Investigator: Lisa M. McGregor
Contact: Lisa M. McGregor Phone: 717-531-6012
Email not avaialable

Philadelphia, Pennsylvania
Facility: Children's Hospital of Philadelphia
Investigator: Jane E. Minturn
Contact: Jane E. Minturn Phone: 215-590-2810
Email not avaialable

Pittsburgh, Pennsylvania
Facility: Children's Hospital of Pittsburgh of UPMC
Investigator: Regina I. Jakacki
Contact: Regina I. Jakacki Phone: 412-692-5573
Email not avaialable

Providence, Rhode Island
Facility: Rhode Island Hospital
Investigator: Jennifer J. Greene Welch
Contact: Jennifer J. Greene Welch Phone: 401-444-1488
Email not avaialable

Charleston, South Carolina
Facility: Medical University of South Carolina
Investigator: Jacqueline M. Kraveka
Contact: Jacqueline M. Kraveka Phone: 843-792-9321
Email not avaialable

Columbia, South Carolina
Facility: Palmetto Health Richland
Investigator: Ronnie W. Neuberg
Contact: Ronnie W. Neuberg Phone: 803-434-3680
Email not avaialable

Greenville, South Carolina
Facility: BI-LO Charities Children's Cancer Center
Investigator: Nichole L. Bryant
Contact: Nichole L. Bryant Phone: 864-241-6251
Email not avaialable

Greenville, South Carolina
Facility: Greenville Cancer Treatment Center
Investigator: Nichole L. Bryant
Contact: Nichole L. Bryant Phone: 864-241-6251
Email not avaialable

Knoxville, Tennessee
Facility: East Tennessee Childrens Hospital
Investigator: Ray C. Pais
Contact: Ray C. Pais Phone: 865-541-8266
Email not avaialable

Nashville, Tennessee
Facility: Vanderbilt University/Ingram Cancer Center
Investigator: Adam Esbenshade
Contact: Adam Esbenshade Phone: 800-811-8480
Email not avaialable

Austin, Texas
Facility: Dell Children's Medical Center of Central Texas
Investigator: Amy C. Fowler
Contact: Amy C. Fowler Phone: 214-648-7097
Email not avaialable

Corpus Christi, Texas
Facility: Driscoll Children's Hospital
Investigator: M. C. Johnson
Contact: M. C. Johnson Phone: 361-694-5311
Email not avaialable

Dallas, Texas
Facility: Medical City Dallas Hospital
Investigator: Stanton C. Goldman
Contact: Stanton C. Goldman Phone: 972-566-5588
Email not avaialable

Dallas, Texas
Facility: UT Southwestern/Simmons Cancer Center-Dallas
Investigator: Daniel C. Bowers
Contact: Daniel C. Bowers Phone: 214-648-7097
Email not avaialable

El Paso, Texas
Facility: El Paso Children's Hospital
Investigator: Lisa L. Hartman
Contact: Lisa L. Hartman Phone: 888-823-5923
Click HERE to send email to this center

Fort Worth, Texas
Facility: Cook Children's Medical Center
Investigator: Mary Meaghan P. Granger
Contact: Mary Meaghan P. Granger Phone: 682-885-2103
Email not avaialable

Houston, Texas
Facility: Baylor College of Medicine
Investigator: Jack M. Su
Contact: Jack M. Su Phone: 713-798-1354
Click HERE to send email to this center

Lubbock, Texas
Facility: Covenant Children's Hospital
Investigator: Latha Prasannan
Contact: Latha Prasannan Phone: 806-725-8000
Click HERE to send email to this center

San Antonio, Texas
Facility: Methodist Children's Hospital of South Texas
Investigator: Gerardo Quezada
Contact: Gerardo Quezada Phone: 888-823-5923
Click HERE to send email to this center

Salt Lake City, Utah
Facility: Primary Children's Hospital
Investigator: Phillip E. Barnette
Contact: Phillip E. Barnette Phone: 801-585-5270
Email not avaialable

Burlington, Vermont
Facility: University of Vermont College of Medicine
Investigator: Alan C. Homans
Contact: Alan C. Homans Phone: 802-656-4101
Email not avaialable

Norfolk, Virginia
Facility: Childrens Hospital-King's Daughters
Investigator: Eric J. Lowe
Contact: Eric J. Lowe Phone: 757-668-7243
Email not avaialable

Richmond, Virginia
Facility: Virginia Commonwealth University/Massey Cancer Center
Investigator: Asadullah Khan
Contact: Asadullah Khan Phone: 804-628-1939
Email not avaialable

Seattle, Washington
Facility: Seattle Children's Hospital
Investigator: Douglas S. Hawkins
Contact: Douglas S. Hawkins Phone: 866-987-2000
Email not avaialable

Spokane, Washington
Facility: Providence Sacred Heart Medical Center and Children's Hospital
Investigator: Judy L. Felgenhauer
Contact: Judy L. Felgenhauer Phone: 800-228-6618
Click HERE to send email to this center

Madison, Wisconsin
Facility: University of Wisconsin Hospital and Clinics
Investigator: Kenneth B. De Santes
Contact: Kenneth B. De Santes Phone: 715-422-7718
Email not avaialable

Marshfield, Wisconsin
Facility: Marshfield Clinic
Investigator: Michael J. McManus
Contact: Michael J. McManus Phone: 715-389-4457
Email not avaialable

Milwaukee, Wisconsin
Facility: Midwest Children's Cancer Center
Investigator: Sachin S. Jogal
Contact: Sachin S. Jogal Phone: 414-805-4380
Email not avaialable




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