Clinical Trial Details
Braintumor Website

[Information provided by: ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

NCT00749723 : Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children
PhasePhase 2/Phase 3
AgesMin: 3 Months Max: 30 Years
Eligibility
Inclusion Criteria:

Disease Characteristics

- Histologically confirmed Medulloblastoma, cerebral PNET or Ependymoma

- Refractory or relapsed disease

- Measurable disease by MRI or detection of tumor cells in cerebrospinal fluid
Patients characteristics

- Performance status ECOG ? 3 or Karnofsky Status ? 40%

- Life expectancy ? 8 weeks

Hematological:

- Absolute leukocyte count ? 2.0 x 10^9 /l

- Hemoglobin ? 10g/dl

- Platelet count ? 70 x 10^9/l

Renal:

- Creatinine no greater than 1.5 times UNL

- No overt renal disease

Hepatic:

- Bilirubin less than 2.5 times UNL

- AST and ALT less than 5 times UNL

- No overt hepatic disease

Pulmonary:

- No overt pulmonary disease

Cardiovascular:

- No overt cardiovascular disease

Other:

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- No uncontrolled infection Prior concurrent therapy

- More than 2 weeks since prior systemic chemotherapy

- More than 4 weeks since prior radiotherapy

- No other concurrent anticancer or experimental drugs Examinations required

- Examination of lumbar CSF

- Cranial and spinal MRI within 14 days prior to start of treatment
LinksPermanent Link to THIS page: http://virtualtrials.com/nct/display1trial.cfm?nct=NCT00749723      |      Link to official Clinicaltrials.gov listing
Locations
Aachen,
Germany

Facility: Universitätskinderklinik Aachen
Investigator:
Contact: R Mertens, MD Phone: +49(0)241-8089-902
Click HERE to send email to this center

Augsburg,
Germany

Facility: Klinikum Augsburg, Klinik für Kinder- und Jugendmedizin
Investigator:
Contact: A Gnekow, MD Phone: +49(0)821-400-3631
Click HERE to send email to this center

Berlin,
Germany

Facility: Charité Klinikum Campus Virchow, Kinderklinik
Investigator:
Contact: Pablo Hernaiz-Driever, MD Phone: +49(0)30-450-566-173
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Berlin,
Germany

Facility: Helios Klinikum Berlin-Buch, Klinik für Kinderheilkunde und Jugendmedizin
Investigator:
Contact: Lothar Schweigerer, MD Phone: +49(0)30-9401-545 00
Click HERE to send email to this center

Bielefeld,
Germany

Facility: Klinik ür Kinder- und Jugendmedizin in Bethel
Investigator:
Contact: Norbert Jorch, MD Phone: +49(0)521-772-78050
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Bonn,
Germany

Facility: Universitätskinderklinik Bonn
Investigator:
Contact: Carola Weber, MD Phone: +49-228-2873-3206
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Braunschweig,
Germany

Facility: Städtisches Klinikum Braunschweig, Kinderklinik
Investigator:
Contact: W Eberl, MD Phone: +49 (0)531 595 1277
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Bremen,
Germany

Facility: Klinikum Bremen-Mitte
Investigator:
Contact: arnulf pekrun, MD Phone: +49-421-497-3656
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Cottbus,
Germany

Facility: Carl-Thiele-Klinikum Cottbus, Zentrum für Kinderheilkunde
Investigator:
Contact: G Böschow, MD Phone: +49-355-46-2332
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Datteln,
Germany

Facility: Vestische Kinder- und Jugendklinik Datteln
Investigator:
Contact: Thomas Wiesel, MD Phone: +49(0)2363-975-221
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Dortmund,
Germany

Facility: Klinikum Dortmund, Klinik für Kinder- und Jugendmedizin
Investigator:
Contact: Dominik Schneider, MD Phone: +49 (0)231-953-21670
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Dresden,
Germany

Facility: Universitätsklinikum Dresden, Kinderklinik
Investigator:
Contact: Meinolf Suttorp, MD Phone: +49(0)351-458-3522
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Duisburg,
Germany

Facility: Klinikum Duisburg, Klinik für Kinder-und Jugendmedizin
Investigator:
Contact: R Schramedei, MD Phone: +49 (0)203 733-3201
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Düsseldorf,
Germany

Facility: Universitätskinderklinik Düsseldorf
Investigator:
Contact: Arndt Borkhardt, MD Phone: +49 211 811 7680
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Erfurt,
Germany

Facility: Helios Klinikum Erfurt, Zentrum für Kinderheilkunde
Investigator:
Contact: Axel Sauerbrey, MD Phone: +49 (0)361-781-4500
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Erlangen,
Germany

Facility: Universitätskinderklinik Erlangen
Investigator:
Contact: Thorsten Langer, MD Phone: +49 (0)9131-853-3731
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Essen,
Germany

Facility: Universitätskinderklinik Essen
Investigator:
Contact: Regina Wieland, MD Phone: +49(0)201-723-3350
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Frankfurt/Main,
Germany

Facility: Klinikum der Wolfgang Goethe Universität, Klinik für Kinderheilkunde
Investigator:
Contact: Thomas Klingebiel, MD Phone: +49 (0)69-6301-5094
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Freiburg,
Germany

Facility: Universitätskinderklinik Freiburg
Investigator:
Contact: Charlotte Niemeyer, MD Phone: +49 (0)761-270-4506
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Gießen,
Germany

Facility: Universitätsklinikum Gießen und Marburg, Zentrum für Kinderheilkunde
Investigator:
Contact: Alfred Reiter, MD Phone: +49 (0)641-99-43400
Click HERE to send email to this center

Göttingen,
Germany

Facility: Universitätskinderklinik Göttingen
Investigator:
Contact: M Lakomek, MD Phone: +49 (0)551-39-6214
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Greifswald,
Germany

Facility: Universitätskinderklinik Greifswald
Investigator:
Contact: H Lode, MD Phone: +49(0)3834-866321
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Halle/Saale,
Germany

Facility: Martin-Luther-Universität Halle Wittenberg
Investigator:
Contact: Dieter Körholz, MD Phone: +49 (0)345-557-2227
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Hamburg,
Germany

Facility: Universitätskinderklinik Hamburg-Eppendorf
Investigator:
Contact: U Kordes, MD Phone: +49(0)40-42803-3796
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Hannover,
Germany

Facility: Medizinische Hochschule, Zentrum für Kinderheilkunde
Investigator:
Contact: Rita Beier, MD Phone: +49(0)511-532-9117
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Heidelberg,
Germany

Facility: Universitätskinderklinik Heidelberg
Investigator:
Contact: Olaf Witt Phone: +49 (0)6221-56-4555
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Heilbronn,
Germany

Facility: SLK Kinderklinik Heilbronn
Investigator:
Contact: Holger Hauch, MD Phone: +49(0)7131-49-3702
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Herdecke,
Germany

Facility: Gemeinschaftskrankenhaus Herdecke, Kinderklinik
Investigator:
Contact: Alfred Längler, MD Phone: +49 (0)2330-62-3893
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Homburg/Saar,
Germany

Facility: Universitätskinderklinik
Investigator:
Contact: Norbert Graf, MD Phone: +49 (0)6841-162-8397
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Jena,
Germany

Facility: Friedrich Schiller Universität, Klinik für Kinder-und Jugendmedizin
Investigator:
Contact: Bernd Gruhn, MD Phone: +49(0)3641-938253
Click HERE to send email to this center

Karlsruhe,
Germany

Facility: Städtisches Krankenhaus, Klinik für Kinder- und Jugendmedizin
Investigator:
Contact: Alfred Leipold, MD Phone: 049(0)721-974-3230
Click HERE to send email to this center

Kassel,
Germany

Facility: Klinikum Kassel, Kinderklinik
Investigator:
Contact: Michaela Nathrath, MD Phone: +49(0)561-980-3380
Click HERE to send email to this center

Kiel,
Germany

Facility: UKSH, Campus Kiel, Klinik für Allg. Pädiatrie
Investigator:
Contact: A Claviez, MD Phone: +49(0)431-597-1622
Click HERE to send email to this center

Koblenz,
Germany

Facility: Städtisches Klinikum Kemperhof, Klinik für Kinder- und Jugendmedizin
Investigator:
Contact: Rudolf Ferrari, MD Phone: +49 (0)261-499-2602
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Köln,
Germany

Facility: Universitätskinderklinik Köln
Investigator:
Contact: Frank Berthold, MD Phone: +49(0)221-478-4380
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Leipzig,
Germany

Facility: Universitätskinderklinik Leipzig
Investigator:
Contact: Holger Christiansen, MD Phone: +49 (0)341-97-26151
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Lübeck,
Germany

Facility: Universitätskinderklinik Lübeck
Investigator:
Contact: M Lauten, MD Phone: +49(0)451-500-2565
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Magdeburg,
Germany

Facility: Otto-von-Guericke-Universität, Zentrum für Kinderheilkunde
Investigator:
Contact: Peter Vorwerk, MD Phone: +49(0)391-67-24240
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Mainz,
Germany

Facility: Universitätskinderklinik Mainz
Investigator:
Contact: M. Dittrich, MD Phone: +49 (0)6131-17-2112
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Mannheim,
Germany

Facility: Universitätskinderklinik Mannheim
Investigator:
Contact: Matthias Dürken, MD Phone: +49(0)621-383-2244
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Marburg,
Germany

Facility: Universitätskinderklinik Marburg
Investigator:
Contact: Alfred Reiter, MD Phone: +49 (0)6421-58-62649
Click HERE to send email to this center

Minden,
Germany

Facility: Klinikum Minden III, Klinik für Kinder-und Jugendheilkunde
Investigator:
Contact: Bernhard Erdlenbruch, MD Phone: +49(0)571-790-4001
Click HERE to send email to this center

München,
Germany

Facility: Städtisches Krankenhaus München-Schwabing, Kinderklinik der TU München
Investigator:
Contact: Uta Behrends, MD Phone: +49(0)89-3068-2887
Click HERE to send email to this center

München,
Germany

Facility: Dr. von Haunersches Kinderspital
Investigator:
Contact: Irene Schmid, MD Phone: +49(0)89-5160-2856
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Münster,
Germany

Facility: Universitätskinderklinik Münster
Investigator:
Contact: R Straeter, MD Phone: +49(0)251-83-47742
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Nürnberg,
Germany

Facility: Cnopf'sche Kinderklinik
Investigator:
Contact: Wolfram Scheurlen, MD Phone: +49(1)0911-3340-308
Click HERE to send email to this center

Oldenburg,
Germany

Facility: Klinikum Oldenburg, Zentrum für Kinder-und Jugendmedizin
Investigator:
Contact: Hermann Müller, MD Phone: +49(0)441-403-2013
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Regensburg,
Germany

Facility: Universitäts-Kinderklinik
Investigator:
Contact: S Corbacioglu, MD Phone: +49(0)941-944 2101
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Rostock,
Germany

Facility: Universitätskinderklinik Rostock
Investigator:
Contact: Carl-Friedrich Classen, MD
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St. Augustin,
Germany

Facility: Asklepios Klinik St. Augustin GmbH
Investigator:
Contact: Harald Reinhard, MD Phone: +49(0)2241-249305
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Stuttgart,
Germany

Facility: Olgahospital-Pädiatrisches Zentrum
Investigator:
Contact: S Bielack, MD Phone: +49(0)711-992-2461
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Tübingen,
Germany

Facility: Universitätskinderklinik Tübingen
Investigator:
Contact: Martin Ebinger, MD Phone: +49(0)7071-298-4446
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Ulm,
Germany

Facility: Univeritätsklinikum Ulm, Abteilung Kinder-und Jugendmedizin
Investigator:
Contact: Klaus-Michael Debatin, MD Phone: +49(0)731-500-27700
Click HERE to send email to this center

Würzburg,
Germany

Facility: Universitätskinderklinik Würzburg
Investigator:
Contact: P Schlegel, MD Phone: +49(0)931-201-27728
Click HERE to send email to this center




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