Details For Selected Brain Tumor Treatment

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Last updated refers to the date when our listing for each treatment was last updated.
ID is our internal ID - starting with VT.
Min Karnofsky is a general guide to how well you have to function to use this treatment
For trials that also have a NCT number, you can click that number to pop up the listing from the clinicaltrials.gov website.

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		Treatment Name:		A Phase I/II Trial of PEG-Interferon Alfa-2B (PEG-Intron) for Plexiform Neurofibromas (NF1 patients)

		Keywords:		PEG-Intron

		Phase:		Phase 1/2

		Treatment ID#s:		VT936 NCT00253474

		Age Group:		Adult And Pediatric

		Min Karnofsky Score:		70: Cares for self, unable to perform normal activity or to do active work

		Conditions:		Newly Diagnosed: Y Recurrent: Y Prior Surgery is Allowed Prior Radiation is Allowed Prior Chemotherapy is Allowed Patients are eligible for this study if they have a progressive plexiform neurofibroma which is not surgically resectable and for which there is no standard treatment. Patients without biopsy proof of plexiform neurofibroma must have at least one other diagnostic criteria of NF1.

		Last Updated:		12/04/2005

		Tumor Types:		Pediatric Brain Tumors


		Comments:		Peg-Intron is given as a sub-Q injection once weekly. This is a dose escalaltion study starting at 3.0ug/kg/week. Each additional level will have a dose increase of 1.5 ug/kg/wk. 3-6 patients will be treated at each dose level to assess the side-effects of the treatment. The patient may be treated for up to 2 years as long as there is no tumor progression or unacceptable side-effects.

		Treatment Type:		Less-Toxics.

		Contact:		Children`s National Medical Center Roger Packer, MD Principal Investigator 111 Michigan Avenue NW Dept. of Neurology Washington, DC 20010 Phone:202-884-2120 Click here to send an email Website: cnmc.org Children`s Memorial Hospital Falk Brain Tumor Center Stewart Goldman, MD Medical Director Neuro-Oncology Box 30 2300 Children`s Plaza Chicago, IL 60614 Phone:773-880-3513 Fax: 773-880-3223 Click here to send an email Children`s Hospitals and Clinics - St. Paul, Christopher Moertel, MD St. Paul, MN 55102 Phone:651-220-6732 Click here to send an email NYU Medical Center Jeffrey Allen, MD 317 E. 34th Street, 10th Floor New York, NY 10016 Phone:212-263-6725 Click here to send an email Children`s Hospital of Pittsburgh Regina Jakacki, MD Pittsburgh, PA 15213 Phone:412-692-5055 Click here to send an email

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