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  • Last updated refers to the date when our listing for each treatment was last updated.
  • ID is our internal ID - starting with VT.
  • Min Karnofsky is a general guide to how well you have to function to use this treatment
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Treatment Name: Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone and Cytarabine in Treating Patients With Primary CNS Lymphoma
Keywords: Methotrexate, Carboplatine
Phase: Phase 2
Treatment ID#s: VT716         NCT00074178
Age Group: Adults Only
Min Karnofsky Score: 50: Requires considerable assistance and frequent medical care
Conditions: Newly Diagnosed: Y
Recurrent: N
Prior Surgery is Allowed
Prior Radiation is Not Allowed
Prior Chemotherapy is Allowed
First relapse of NHL in the CNS, No prior radiotherapy to the CNS, No prior bone marrow transplantation
Last Updated: 05/01/2007
Tumor Types: Lymphomas
Metastatic Brain Tumor
Comments: Treatment includes high-dose methotrexate given IV and intra-arterial chemotherapy with carboplatine given inconjunction with blood-brain barrier disruption. After 4 cycles patients in complete response undergo high dose chemotherapy with autologous peripheral stem cell transplantation. No radiotherapy id given to responding patients.
Treatment Type: Chemotherapy.
Contact: Cleveland Clinic Brain Tumor and Neuro-Oncology Center
Gene Barnett, M.D.
Professor and Chairman Brain Tumor Institute
R20
9500 Euclid Ave.
Cleveland, OH 44195
Phone:216-445-1379
Fax: 216-444-0924
Click here to send an email
Website: ccf.org
Oregon Health Sciences University
Edward Neuwelt, M.D.
Professor
Contact: Dr. Neuwelt
3181 SW Sam Jackson Park Rd
L603
Portland, OR 97239
Phone:(503)494-5626
Fax: (503)494-5627
Click here to send an email
Website: www.ohsu.edu/bbb


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