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  • Last updated refers to the date when our listing for each treatment was last updated.
  • ID is our internal ID - starting with VT.
  • Min Karnofsky is a general guide to how well you have to function to use this treatment
  • For trials that also have a NCT number, you can click that number to pop up the listing from the clinicaltrials.gov website.
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Treatment Name: Phase I/II Trial of Irinotecan plus Lenalidomide in Adult Patients with Recurrent Glioblastoma Multiforme
Keywords: Lenalidomide, thalidomide, Irinotecan
Phase: Phase 1/2
Treatment ID#s: VT1863         2006-0472
Age Group: Adults Only
Min Karnofsky Score: 60: Requires occasional assistance but is able to care for most of own needs
Conditions: Newly Diagnosed: N
Recurrent: Y
Prior Surgery is Allowed
Prior Radiation is Allowed
Prior Chemotherapy is Allowed
Phase I: WHO grade III and IV malignant gliomas Phase II: WHO grade IV malignant glioma (GBM and gliosarcoma)
Last Updated: 05/28/2008
Tumor Types: Anaplastic Astrocytoma
Glioblastoma Multiforme
Gliosarcoma
Mixed Glioma
Oligodendroglioma High Grade
Comments: Lenalidomide is an analogue of thalidomide, but is several times more potent as an anti-angiogenic agent without toxicities associated with thalidomide. The goal of the Phase I study is to find the highest safe dose of Irinotecan plus Lenalidomide in patients with malignant gliomas. The Phase II study will determine the effectiveness of this combination against gliomas.
Treatment Type: Chemotherapy.
Contact: MD Anderson Cancer Center
Jan Esenwein
Program Coordinator, Brain Tumor Program
Contact: Jan Esenwein or Marie Woodward
1515 Holcombe Blvd
Houston, TX 77030-
Phone:(713)745-2264
Fax: (713)794-4999
Click here to send an email
Website: www.mdanderson.org/diseases/braincancer/



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