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  • Last updated refers to the date when our listing for each treatment was last updated.
  • ID is our internal ID - starting with VT.
  • Min Karnofsky is a general guide to how well you have to function to use this treatment
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Treatment Name: Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients with Malignant Glioma
Keywords: ANG1005, paclitaxel
Phase: Phase 1
Treatment ID#s: VT1862         2007-0931
Age Group: Adults Only
Min Karnofsky Score: Not Specified
Conditions: Newly Diagnosed: N
Recurrent: Y
Prior Surgery is Allowed
Prior Radiation is Allowed
Prior Chemotherapy is Allowed
glioblastoma multiforme, gliosarcoma, anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma (WHO Grades II, II, or IV) with evidence of tumor progression
Last Updated: 05/28/2008
Tumor Types: Anaplastic Astrocytoma
Glioblastoma Multiforme
Gliosarcoma
Mixed Glioma
Oligodendroglioma High Grade
Comments: ANG1005 is a conjugate consisting of paclitaxel and Angiopep2. Angiopep2 is a peptide designed to help drugs cross the brain blood barrier. When ANG1005 is transported across the brain blood barrier and reaches the cancer cells, it is internalized to release paclitaxel. ANG1005 has been shown to inhibit tumor cell proliferation, block tumor cell cycle progression and induce b-tubulin polymerization.
Treatment Type: Chemotherapy.
Contact: MD Anderson Cancer Center
Jan Esenwein
Program Coordinator, Brain Tumor Program
Contact: Jan Esenwein or Marie Woodward
1515 Holcombe Blvd
Houston, TX 77030-
Phone:(713)745-2264
Fax: (713)794-4999
Click here to send an email
Website: www.mdanderson.org/diseases/braincancer/


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