Details For Selected Brain Tumor Treatment
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  • Last updated refers to the date when our listing for each treatment was last updated.
  • ID is our internal ID - starting with VT.
  • Min Karnofsky is a general guide to how well you have to function to use this treatment
  • For trials that also have a NCT number, you can click that number to pop up the listing from the clinicaltrials.gov website.
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Treatment Name: Phase I/II Study of OSI-774 (Erlotinib) and CCI-779 (Temsirolimus) in Patients with Recurrent Malignant Glioma
Keywords: OSI-774 (Erlotinib), CCI-779 (Temsirolimus)
Phase: Phase 1/2
Treatment ID#s: VT1850         NABTC04-02
Age Group: Adults Only
Min Karnofsky Score: 60: Requires occasional assistance but is able to care for most of own needs
Conditions: Newly Diagnosed: N
Recurrent: Y
Prior Surgery is Allowed
Prior Radiation is Allowed
Prior Chemotherapy is Allowed
Recurrent Malignant Glioma
Last Updated: 04/15/2008
Tumor Types: Anaplastic Astrocytoma
Glioblastoma Multiforme
Gliosarcoma
Mixed Glioma
Oligodendroglioma High Grade
Comments: Inhibition of both EGFR and mTOR could potentially result in significant inhibition of the growth of malignant gliomas. OSI-774 inhibits the epidermal growth factor (EGF)-dependent proliferation of cells at nanomolar concentrations and blocks cell progression at the G1 phase. CCI-779 is an immunosuppressive agent that acts to block the activity of mTOR and inhibit key signaling pathways, resulting in inefficient translation of critical mRNAs important for cell cycle progression.
Treatment Type: Immunological, Biological or Targeted Therapy.
Contact: MD Anderson Cancer Center
Jan Esenwein
Program Coordinator, Brain Tumor Program
Contact: Jan Esenwein or Marie Woodward
1515 Holcombe Blvd
Houston, TX 77030-
Phone:(713)745-2264
Fax: (713)794-4999
Click here to send an email
Website: www.mdanderson.org/diseases/braincancer/


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