Details For Selected Brain Tumor Treatment

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Last updated refers to the date when our listing for each treatment was last updated.
ID is our internal ID - starting with VT.
Min Karnofsky is a general guide to how well you have to function to use this treatment
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		Treatment Name:		Phase II Study of CDX-110 in Patients With Glioblastoma Multiforme (GBM) (ACT III)

		Keywords:		CDX-110, vaccine

		Phase:		Phase 2/3

		Treatment ID#s:		VT1765 NCT00458601

		Age Group:		Adults Only

		Min Karnofsky Score:		70: Cares for self, unable to perform normal activity or to do active work

		Conditions:		Newly Diagnosed: Y Recurrent: N Prior Surgery is Allowed Prior Radiation is Allowed Prior Chemotherapy is Allowed

		Last Updated:		03/09/2010

		Tumor Types:		Glioblastoma Multiforme


		Comments:		This trial is for newly diagnosed patients, after having completed surgery, then the standard combination of radiation with temozolomide. You must join within 2-3 weeks after completing radiation, but you are encouraged to talk to the participating center closest to you as soon as possible after diagnosis, as it will take some time to evaluate your eligibility. A live tumor sample is NOT required - just the sample that is usually saved after every surgery (block or slides). CDX-110 is an immunotherapeutic molecule that is intended to induce a tumor-specific immune response in EGFRvIII positive brain cancer. Cells producing EGFRvIII have an enhanced capacity for unregulated growth, survival, invasion, and recruitment of new tumor blood vessels. This Phase II/III study is designed to determine whether the addition of CDX-110 vaccination to a standard of care regimen provides significant benefit for patients. THIS trial is not placebo controlled. Every participant gets thevaccine!

		Treatment Type:		Chemotherapy Radiation Immunological, Biological or Targeted Therapy.

		Contact:		USC Norris Cancer Center Thomas Chen, MD, PHD Contact: Lydia Wilson, NP 1441 Eastlake Avenue Los Angeles, CA 90033 Phone:323-865-3945 Fax: (323)226-7833 Click here to send an email Website: www.norriscancerhospital.com UCLA Medical Center Linda M. Liau, MD, PhD Co-director, Brain Tumor Program David Geffen School of Medicine at UCLA 10833 Le Conte Avenue, CHS 74-145 Los Angeles, CA 90095 Phone:310-267-2621 Fax: 310-825-7245 Click here to send an email Website: neurosurgery.ucla.edu/ UC Irvine Healthcare Daniela Bota, MD PhD 101 The City Drive South Orange, CA 92868 Phone:1-877-824-9111 Click here to send an email Website: www.healthcare.uci.edu/cancer/braintumor/index.asp Stanford Cancer Center Lawrence Recht, MD Contact: Cathy Recht, RN Palo Alto, CA 94305 Phone:650-725-8630 Click here to send an email U. Of California At San Francisco Nicholas Butowski, MD Contact Valerie Kivett 400 Parnassus Ave #0372 San Francisco, CA 94143 Phone:415-353-2076 Fax: 415-353-2167 Click here to send an email Website: neurosurgery.medschool.ucsf.edu/patient_care/bt_center.html Yale University School Of Medicine Joachim Baehring, M.D. Departments of Neurology and Neurosurgery Contact: Theresa Krause, RN 333 Cedar Street, TMP 410 New Haven, CT 06510 Phone:203-785-7284 Click here to send an email Website: yalebraintumorcenter.org/ McKnight Brain Institute Christine Keeling, MD Gainsville, FL 32611 Phone:352-273-9000 Click here to send an email Mayo Clinic-Cancer Clinical Studies Unit Kurt Jaeckle, MD 4500 San Pablo Road Jacksonville, FL 32224 Phone:904-953-6806 Email not available Winship Cancer Institute, Emory University School of Medicine Costas Hadjipanayis, MD Atlanta, GA 30322 Phone:404-778-3091 Click here to send an email Rush University Medical Center Robert Aiken, MD Contact: Elizabeth Jasky, RN 312-942-2388 Chicago, IL 60612 Phone:312-942-2388 Click here to send an email The University of Chicago Hospitals Maciej Lesniak, M.D. Director, Neurosurgical Oncology Neurosurgery, MC 3026 5841 S. Maryland Avenue Chicago, IL 60637 Phone:773-834-4757 Fax: 773-702-3518 Click here to send an email Website: www.chicagobraintumors.org Northwestern University, The Robert H. Lurie Comprehensive Cancer Center Jeffrey Raizer, MD Director, Medical Neuro-oncology Contact: Lilia Gallot, MD, CCRC Chicago, IL 60611 Phone:312-695-1363 Click here to send an email Kellogg Cancer Care Center Nina Paleologos, MD Evanston Hospital Contact: Pat Lada Evanston, IL Phone:847-570-2025 Click here to send an email Dana-Farber Cancer Institute Patrick Wen, MD Center for Neuro-Oncology Boston, MA Phone:617-632-6327 Email not available The John`s Hokins Univ. Michael Lim, MD Contact: Bing Chao Baltimore, MD 21287 Phone:410-502-0627 Click here to send an email Henry Ford Hospital Tom MikKelsen, MD, FRCP(C) Co-Director Contact: Dr. Tom Mikelsen Hermelin Brain Tumor Center E&R3096 Henry Ford Hospital 2799 West Grand Blvd Detroit, MI 48202- Phone:313 916-8641 Fax: 313 916-9855 Click here to send an email Website: www.henryfordhealth.org/body.cfm?id=38441&action=detail&ref=968 Edward W. Sparrow Hospital Association Sparrow Regional Cancer Center Muhammad Hamdan, MD Contact: Vicki Gilreath Lansing, MI 48912 Phone:517-364-2811 Click here to send an email St. Mary’s of Michigan Malcolm Field, MD Field Neurosciences Institute Contact: Heather Clark Saginaw, MI 48604 Phone:989-497-3023 Click here to send an email Website: stmarysofmichigan.org The Brain Tumor Center at Duke Henry Friedman, MD Contact: Dr. Henry S. Friedman Rm 047 Baker House, Hospital South Trent Drive Durham, NC 27710- Phone:(919)684-5301 Fax: (919)684-6674 Click here to send an email Website: www.cancer.duke.edu/btc Hackensack University Medical Center Viswanathan Rajaraman, MD, FRCS Chief, Division of Neuro-oncology, Cancer Center 20 Prospect Avenue, Suite 907 Hackensack, NJ 07601 Phone:201 342 2550 Fax: 201 342 7171 Click here to send an email Dent Neurologic Institute Laszlo Mechtler, MD Contact: Lori Zdrojewski Buffalo, NY Phone:716-250-2055 Click here to send an email Website: dentinstitute.com Columbia University Medical Center Rose Lai, MD Contact: Mahogany Ayele, RN New York, NY 10032 Phone:212-305-2756 Click here to send an email Weil Cornell Medical College-New York Presbyterian Hospital Theodore Schwartz, MD New York, NY 10021 Phone:212-746-5620 Click here to send an email SUNY Upstate Medical University at Syracuse Gregory Canute, M.D. Associate Professor Department of Neurosurgery 750 East Adams Street Syracuse, NY 13210 Phone:315-464-5513 Fax: 315-464-6383 Click here to send an email Website: www.upstate.edu/neurosurgery University Hospital – Case Medical Center Andrew Sloan, M.D. Contact: Christopher Murphy RN; Cleveland, OH 44106 Phone:216-983-0796 Click here to send an email Cleveland Clinic Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center Michael Vogelbaum, MD, PhD Director, Center for Translational Therapeutics Cleveland, OH 44195 Phone:216-444-5782 Click here to send an email Website: my.clevelandclinic.org/brain_tumor/default.aspx University of Cincinnati Division of Hematology-Oncology Margie Gerena-Lewis, MD Contact: Alison Kasti Columbus, OH Phone:513-584-0436 Click here to send an email U. Of Pennsylvania James Schuster, MD 3400 Spruce Street Philadelphia, PA 19104 Phone:215-662-3487 Click here to send an email MD Anderson Cancer Center Morris Groves, MD Contact: Teresa Hanna 1400 Holcombe Blvd Houston, TX 77030 Phone:713-563-1603 Click here to send an email Website: www.mdanderson.org/diseases/braincancer/ U. of Texas at San Antonio Aidnag Diaz, MD San Antonio, TX 78229 Phone:210-450-1130 Click here to send an email University of Utah Medical Center, Huntsman Cancer Institute Randy Jensen, MD, PhD Dept. of Neurosurgery, 3B409 SOM 30 North 1900 East Salt Lake City, UT 84132 Phone:801-581-6908 Fax: 801-581-4385 Click here to send an email University of Virginia Health System David Schiff, MD Co-Director, Division of Neuro-Oncology Department of Neurology Box 800432 Charlottesville, VA 22908-0432 Phone:434-982-4415 Fax: 434-982-4467 Click here to send an email Website: www.uvabraintumor.com Fred Hutchinson Cancer Research Center Maciej Mrugala, MD U. Of Washington School Of Medicine Contact: Robyn Haaf, RN Seattle, WA 98195 Phone:206-616-7117 Click here to send an email