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- Last updated refers to the date when our listing for each treatment was last updated.
- ID is our internal ID - starting with VT.
- Min Karnofsky is a general guide to how well you have to function to use this treatment
- For trials that also have a NCT number, you can click that number to pop up the listing from the clinicaltrials.gov website.
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Treatment Name: |
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A Phase I, Molecular Biology, and Phase II Study of Lapatinib (GW572016) in Pediatric Patients with Recurrent or Refractory Medulloblastoma, Malignant Glioma or Ependymoma
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Keywords: |
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Lapatinib (GW572016) |
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Phase: |
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Phase 1/2 |
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Treatment ID#s: |
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VT1509
NCT00095940
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Age Group: |
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Pediatric Only |
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Min Karnofsky Score: |
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50: Requires considerable assistance and frequent medical care |
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Conditions: |
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Newly Diagnosed: N
Recurrent: Y
Prior Surgery is Allowed
Prior Radiation is Allowed
Prior Chemotherapy is Allowed
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Last Updated: |
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11/27/2005 |
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Tumor Types: |
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Anaplastic Astrocytoma
Any Malignant Brain Tumor
Ependyoma
Glioblastoma Multiforme
Gliosarcoma
Medulloblastoma
Pediatric Brain Tumors
PNET Tumor
Recurrent Malignant Pediatric Brain Tumors |
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Comments: |
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In this study, lapatinib will be tested in children with brain tumors that are either recurrent (the disease has come back), or refractory (the disease was not responsive to therapy). In laboratory and animal research studies, lapatanib was able to block the receptor site on the cell (a site on the surface of the cell which acts as a lock and key), which signals a brain tumor cell to divide and grow. Lapatinib has been tested in adults and some evidence has shown that it can shrink, or at least stop the tumor from growing. We are now testing this new experimental drug in children, with the hope of finding a new drug that works against childhood brain tumors. This is the first time this drug will be tested in children.
Lapatinib will be given orally (in pill form), twice a day, for 28 days. Each 28 day period of time is called a cycle. A total of 26 cycles (two years) of the drug may be administered if there are no unacceptable side effects or tumor growth.
For more information: www.stjude.org/brain-tumors |
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Treatment Type: |
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Chemotherapy. |
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Contact: |
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Children`s National Medical Center
Roger Packer, MD
Principal Investigator
111 Michigan Avenue NW
Dept. of Neurology
Washington, DC 20010
Phone:202-884-2120
Click here to send an email
Website: cnmc.org
Children`s Memorial Hospital - Chicago
Stewart Goldman, MD
Chicago, IL 60614
Phone:773-880-4585
Email not available
Dana-Farber Cancer Institute
Mark William Kieran, MD
Director, Pediatric Medical Neuro-Oncology
44 Binney Street, Room SW 331
Boston, MA 02115
Phone:(617) 632-4386
Fax: (617) 632-4897
Click here to send an email
The Brain Tumor Center at Duke
Henry Friedman, MD
Contact: Dr. Henry S. Friedman
Rm 047 Baker House, Hospital South
Trent Drive
Durham, NC 27710-
Phone:(919)684-5301
Fax: (919)684-6674
Click here to send an email
Website: www.cancer.duke.edu/btc
Childrens Hospital of Philadelphia
Peter Phillips, MD
6th Floor - Dept. Neurology
34th and Civic Center Blvd
Philadelphia, PA 19104
Phone:215-590-5188
Click here to send an email
Website: www.nabtt.org/penn.html
Children`s Hospital of Pittsburgh
Ian F. Pollack, MD, FACS
Walter Dandy Professor of Neurosurgery
Contact: Dr. Ian Pollack
University of Pittsburgh School of Medicine
3471 Fifth Avenue
Pittsburgh, PA 15213
Phone:(412)692-5881
Fax: (412)692-5921
Click here to send an email
Website: www.neurosurgery.pitt.edu/faculty/pollack.html
St. Jude Childrens Research Hospital
Jennifer Havens, RN
Brain Tumor Coordinator
332 North Lauderdale
Room C-6058
Memphis, TN 38105
Phone:(901) 495-5007
Fax: (901)495-5353
Click here to send an email
Website: www.stjude.org/brain-tumors
St. Jude Children`s Research Hospital
Larry E. Kun, MD
Memphis, TN 38105
Phone:901-495-3565
Click here to send an email
Texas Children`s Cancer Center and Hematology Service at Texas Children`s Hospital
Susan M. Blaney, MD
Houston, TX 77030-2399
Phone:832-822-1482
Click here to send an email
Children`s Hospital and Regional Medical Center - Seattle
Jeffrey R. Geyer, MD
Seattle, WA 98105
Phone:206-987-6664
Email not available |
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