Details For Selected Brain Tumor Treatment

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		Treatment Name:		Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma

		Phase:		Phase 2

		Treatment ID#:		867 DM00-309

		Age Group:		Adults Only

		Min Karnofsky Score:		50: Requires considerable assistance and frequent medical care

		Conditions:		Prior Surgery is Allowed Prior Radiation is Sometimes Allowed Prior Chemotherapy is Sometimes Allowed meningeal gliomatosis

		Last Updated:		11/26/2005

		Tumor Types:		Lymphomas


		Comments:		Recent clinical trials demonstrating the activity of temozolomide against malignant gliomas make this agent a potentially useful treatment of both parenchymal and leptomeningeal tumors. Furthermore, animal studies have shown that between 41-44% of the serum drug concentration is achieved in the cerebrospinal fluid. Among other known active systemic agents for malignant glioma, only procarbazine achieves adequate CSF concentrations, but temozolomide offers the advantage of oral administration.

		Treatment Type:		Chemotherapy

		Contact:		Thomas H. Davis MD Norris Cotton Cancer Center, Lebanon, NH 03756 USA Phone: Fax: E-mail: Website:

Last updated refers to the date when our listing for each treatment was last updated.
ID is a combination of our internal ID and the official ID for the trial, if any.
Min Karnofsky is a general guide to how well you have to function to use this treatment

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